Pharmacology for Health Professionals, 6e
- 6th Edition - November 2, 2022
- Imprint: Elsevier
- Authors: Kathleen Knights, Andrew Rowland, Shaunagh Darroch, Mary Bushell
- Language: English
- Paperback ISBN:9 7 8 - 0 - 7 2 9 5 - 4 3 9 0 - 3
- eBook ISBN:9 7 8 - 0 - 7 2 9 5 - 9 7 7 1 - 5
- eBook ISBN:9 7 8 - 0 - 7 2 9 5 - 9 7 7 2 - 2
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- Title page
- Table of Contents
- Copyright
- Organisation of content
- Guide to text
- Preface
- Acknowledgements
- About the authors
- Dedication
- List of Tables
- List of Illustrations
- Unit 1. Introduction to Pharmacology
- 1. Drugs and medicines
- Introduction
- Drugs and medicines
- A brief history of pharmacology
- Drug discovery and development
- Drug formulations
- Drug names and classifications
- Drug information
- References
- Acknowledgements
- Online resources
- 2. Clinical, ethical and legal foundations of pharmacotherapy
- Clinical aspects of pharmacotherapy
- Ethical aspects of pharmacotherapy
- Legal aspects of pharmacotherapy
- References
- Online resources
- Unit 2. Principles of Pharmacology
- 3. Molecular drug targets and pharmacodynamics
- Introduction
- Molecular drug targets
- Pharmacodynamics
- References
- 4. Drug absorption, distribution, metabolism and excretion
- Introduction
- Drug absorption
- Bioavailability
- Distribution
- Drug metabolism
- Excretion of drugs and drug metabolites
- Pharmacokinetics during pregnancy and early life
- References
- 5. Pharmacokinetics and dosing regimens
- Introduction
- Plasma concentration–time profile of a drug
- Key pharmacokinetic concept: Clearance
- Key pharmacokinetic concept: Volume of distribution
- Key pharmacokinetic concept: Half-life
- Dosage measurements and calculations
- Dosage calculations
- References
- 6. Precision medicine
- Introduction
- Pharmacogenetics
- References
- 7. Adverse drug reactions and drug interactions
- Introduction
- Adverse drug reactions
- Drug–drug interactions
- Classification of drug interactions
- References
- Unit 3. Drugs Affecting the Peripheral Nervous System
- 8. Drugs affecting cholinergic transmission
- Introduction: General overview of the autonomic and somatic nervous systems
- Neurochemical transmission
- Drugs acting at muscarinic receptors
- Acetylcholinesterase
- Anticholinesterase agents
- Drugs acting at nicotinic receptors
- Somatic nervous system
- Neuromuscular blocking drugs
- Reversal of neuromuscular blockade
- References
- Online resources
- 9. Drugs affecting noradrenergic transmission
- Introduction
- Drugs acting at adrenergic receptors
- Adrenoceptor antagonists
- References
- Online resources
- Unit 4. Drugs Affecting the Heart and Vascular System
- 10. Drugs affecting cardiac function
- Introduction: The heart
- Drugs affecting cardiac function
- Dysrhythmias and antidysrhythmic drugs
- References
- Online resources
- 11. Drugs affecting vascular smooth muscle
- Introduction: The vascular system
- Angina
- Direct-acting vasodilator drugs
- Indirect-acting vasodilator drugs
- Aldosterone-receptor antagonists
- Peripheral vascular disease
- References
- Online resources
- 12. Lipid-lowering drugs
- Introduction
- Management strategies for dyslipidaemia
- References
- Online resources
- 13. Drugs affecting thrombosis and haemostasis
- Introduction
- Anticoagulant drugs
- Antiplatelet agents
- Thrombolytic drugs
- Haemostatic and antifibrinolytic drugs
- References
- Online resource
- 14. Drugs affecting the haemopoietic system
- Introduction
- Haematinics
- Haemopoietics
- References
- Online resources
- Unit 5. Drugs Affecting the Respiratory System
- 15. Drugs used in respiratory disorders
- Introduction: The respiratory system, respiratory disease and its treatment
- Considerations for drug delivery to the airways: Drugs by inhalation
- Medical gases
- Respiratory stimulants and depressants
- Drugs affecting secretions and mucociliary transport
- Drugs affecting the nose
- Drug treatment of asthma
- Drug treatment of chronic obstructive pulmonary disease
- Drugs used in respiratory tract infections
- References
- Online resources
- Unit 6. Drugs Affecting the Gastrointestinal System
- 16. Drugs affecting the upper and lower gastrointestinal tract
- Introduction: The gastrointestinal system, gastrointestinal disease and drugs affecting the gastrointestinal system
- The upper gastrointestinal tract
- The lower gastrointestinal tract
- References
- Online resources
- Unit 7. Drugs Affecting the Urinary System
- 17. Drugs affecting the kidney and bladder
- Introduction: The kidneys
- Diuretics
- Drugs for bladder dysfunction
- References
- Online resources
- Unit 8. Drugs Affecting the Central Nervous System
- 18. Central nervous system overview and anaesthetics
- Introduction: The central nervous system
- General anaesthesia
- Local anaesthesia
- References
- Online resources
- 19. Analgesics
- Introduction
- Pain management
- Analgesic drugs
- References
- Online resources
- 20. Antianxiety, sedative and hypnotic drugs
- Introduction: Sleep and anxiety
- Sedatives, hypnotics and anxiolytics
- Benzodiazepines
- Other anxiolytic and sedative/hypnotic agents
- References
- Online resources
- 21. Antiepileptic drugs
- Introduction: Epilepsy
- Antiepileptic drug therapy
- References
- Online resources
- 22. Psychotropic agents
- Introduction: Psychiatry and central nervous system neurotransmitters
- Clinical aspects of drug therapy in psychiatry
- Antipsychotic agents
- Treating affective disorders
- Lithium: The antimanic drug
- References
- Online resources
- 23. Central nervous system stimulants
- Introduction: History and uses of stimulants
- Amphetamines
- Methylxanthines
- References
- Online resources
- 24. Drugs for neurodegenerative disorders and headache
- Introduction
- Drug treatment of movement disorders
- Dementias, delirium and stroke
- Drug treatment in migraine and other headaches
- References
- Online resources
- 25. Drug dependence and social pharmacology
- Introduction
- Drug abuse and dependence
- Dependence on opioids
- Central nervous system depressants
- Central nervous system stimulants
- Psychotomimetics
- Other drugs of abuse
- References
- Online resources
- Unit 9. Drugs Affecting the Endocrine System
- 26. The neuroendocrine system and pituitary gland
- Introduction
- Hormones as drugs
- Neuroendocrine controls: Hypothalamic factors and related drugs
- Anterior pituitary gland hormones and related drugs
- Posterior pituitary gland hormones and related drugs
- References
- Online resources
- 27. The thyroid gland, the parathyroid glands and bone disorders
- Introduction
- Pharmacotherapy of thyroid disorders
- Pharmacotherapy of parathyroid disorders
- Pharmacotherapy of bone disorders
- References
- Online resources
- 28. The endocrine pancreas and diabetes mellitus
- Introduction
- Pancreatic hormones and diabetes
- Management of type 2 diabetes
- References
- Online resources
- 29. The adrenal cortex and corticosteroids
- Introduction
- Glucocorticoids
- Glucocorticoids used clinically
- Mineralocorticoids
- References
- Online resources
- Unit 10. Drugs Affecting the Reproductive System
- 30. Drugs affecting the female reproductive system
- Introduction: Female reproductive system controls and hormones
- Drugs used in gynaecological disorders
- Contraception
- Drugs during pregnancy, the perinatal period and lactation
- Menopause and hormone replacement therapy
- References
- Online resources
- 31. Drugs affecting the male reproductive system
- Introduction: Male reproductive system controls and hormones
- Drugs used in male reproductive disorders
- Contraception in males
- Drugs that affect sexual functioning (male and female)
- References
- Online resources
- Unit 11. Drugs Used in Neoplastic Diseases
- 32. Principles of cancer therapy
- Introduction
- Treatment of cancer
- Clinical aspects of treating cancer
- Roles of antineoplastic drugs
- Molecular markers
- Dosing
- Adverse drug reactions
- Treatment of adverse drug reactions
- Development of drug resistance
- Age-related considerations
- Clinical trials of anticancer drugs
- Special access schemes
- Orphan drugs
- References
- 33. Antineoplastic drugs
- Cytotoxic antineoplastic drugs
- Hormonal antineoplastic drugs
- Non-cytotoxic antineoplastic drugs
- Immunomodulatory drugs
- Tumour vaccines
- Adjunct therapies
- Palliative care
- References
- Unit 12. Drugs Affecting Body Defences
- 34. Anti-inflammatory and immunomodulating drugs
- Introduction
- Non-steroidal anti-inflammatory drugs
- Disease-modifying antirheumatic drugs
- Immunosuppressant drugs
- Immunostimulant drugs
- Histamine and H1-antihistamines
- Drugs used for the treatment of gout
- References
- Online resources
- Unit 13. Drugs Affecting Microorganisms
- 35. Overview of antimicrobial chemotherapy and antibiotic resistance
- Introduction
- Antimicrobial therapy
- Antibiotic resistance
- Combating antimicrobial drug resistance
- References
- 36. Antibacterial drugs
- Introduction
- Inhibitors of bacterial cell wall synthesis
- Inhibitors of bacterial protein synthesis
- Inhibitors of DNA synthesis
- Miscellaneous antibiotics
- Urinary tract antimicrobials
- References
- 37. Antifungal and antiviral drugs
- Treating fungal infections
- Treating viral infections
- Treating herpesviruses
- Treating influenza and viral respiratory infection
- Treating hepatitis B
- Treating hepatitis C
- Treating coronavirus
- Treating human immunodeficiency virus
- References
- 38. Antiprotozoal, antimycobacterial and anthelmintic drugs
- Protozoal infections
- Amoebiasis
- Mycobacterial infections
- Leprosy
- Helminth infections
- References
- Unit 14. Special Topics
- 39. Drugs affecting the skin
- Introduction
- Application of drugs to the skin
- Sunscreen preparations
- Topical antimicrobial agents
- Anti-inflammatory and immunomodulating agents
- Retinoids and treatment of acne
- Treatment of burns, pressure sores and skin ulcers
- References
- Online resources
- 40. Drugs affecting the eye and ear
- Introduction
- Drugs affecting the eye
- Drugs affecting the ear
- References
- Online resources
- 41. Drugs in aged care
- Introduction
- Changes in pharmacodynamics and pharmacokinetics with ageing
- Drug treatment for older adults
- The impact of drugs on functional outcomes in older adults
- Medication reviews and deprescribing
- References
- Online resources
- 42. Pharmacotherapy of obesity
- Introduction
- Health risks associated with obesity
- Pathophysiology of obesity
- Management of obesity
- The future
- References
- Online resources
- 43. Vaccinations
- Introduction
- References
- Online resources
- 44. Complementary medicines
- Introduction
- Complementary and alternative therapies
- References
- Online resources
- Appendix 1: Abbreviations
- Appendix 2: Glossary
- Appendix 3: Common abbreviations and symbols used in prescriptions
- Appendix 4: Dose calculation examples
- Further readings
- Figure list
- Clinical focus box list
- Drug monograph list
- Figure and picture credits
- Index
- Edition: 6
- Published: November 2, 2022
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780729543903
- eBook ISBN: 9780729597715
- eBook ISBN: 9780729597722
KK
Kathleen Knights
Affiliations and expertise
Professor in Clinical Pharmacology, Flinders University, SA, AustraliaAR
Andrew Rowland
Affiliations and expertise
Senior Lecturer, Department of Clinical
Pharmacology, College of Medicine
and Public Health, Flinders University,
Adelaide, South Australia, AustraliaSD
Shaunagh Darroch
Affiliations and expertise
Pharmacologist, Melbourne, Victoria,
Australia