Pharmacology for Health Professionals, 6e

6th Edition - November 2, 2022
Authors: Kathleen Knights, Andrew Rowland, Shaunagh Darroch, Mary Bushell
Language: English
Paperback ISBN:
9 7 8 - 0 - 7 2 9 5 - 4 3 9 0 - 3
eBook ISBN:
9 7 8 - 0 - 7 2 9 5 - 9 7 7 1 - 5
eBook ISBN:
9 7 8 - 0 - 7 2 9 5 - 9 7 7 2 - 2

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Cover image
Title page
Table of Contents
Copyright
Organisation of content
Guide to text
Preface
Acknowledgements
About the authors
Dedication
List of Tables
List of Illustrations
Unit 1. Introduction to Pharmacology
1. Drugs and medicines
Introduction
Drugs and medicines
A brief history of pharmacology
Drug discovery and development
Drug formulations
Drug names and classifications
Drug information
References
Acknowledgements
Online resources
2. Clinical, ethical and legal foundations of pharmacotherapy
Clinical aspects of pharmacotherapy
Ethical aspects of pharmacotherapy
Legal aspects of pharmacotherapy
References
Online resources
Unit 2. Principles of Pharmacology
3. Molecular drug targets and pharmacodynamics
Introduction
Molecular drug targets
Pharmacodynamics
References
4. Drug absorption, distribution, metabolism and excretion
Introduction
Drug absorption
Bioavailability
Distribution
Drug metabolism
Excretion of drugs and drug metabolites
Pharmacokinetics during pregnancy and early life
References
5. Pharmacokinetics and dosing regimens
Introduction
Plasma concentration–time profile of a drug
Key pharmacokinetic concept: Clearance
Key pharmacokinetic concept: Volume of distribution
Key pharmacokinetic concept: Half-life
Dosage measurements and calculations
Dosage calculations
References
6. Precision medicine
Introduction
Pharmacogenetics
References
7. Adverse drug reactions and drug interactions
Introduction
Adverse drug reactions
Drug–drug interactions
Classification of drug interactions
References
Unit 3. Drugs Affecting the Peripheral Nervous System
8. Drugs affecting cholinergic transmission
Introduction: General overview of the autonomic and somatic nervous systems
Neurochemical transmission
Drugs acting at muscarinic receptors
Acetylcholinesterase
Anticholinesterase agents
Drugs acting at nicotinic receptors
Somatic nervous system
Neuromuscular blocking drugs
Reversal of neuromuscular blockade
References
Online resources
9. Drugs affecting noradrenergic transmission
Introduction
Drugs acting at adrenergic receptors
Adrenoceptor antagonists
References
Online resources
Unit 4. Drugs Affecting the Heart and Vascular System
10. Drugs affecting cardiac function
Introduction: The heart
Drugs affecting cardiac function
Dysrhythmias and antidysrhythmic drugs
References
Online resources
11. Drugs affecting vascular smooth muscle
Introduction: The vascular system
Angina
Direct-acting vasodilator drugs
Indirect-acting vasodilator drugs
Aldosterone-receptor antagonists
Peripheral vascular disease
References
Online resources
12. Lipid-lowering drugs
Introduction
Management strategies for dyslipidaemia
References
Online resources
13. Drugs affecting thrombosis and haemostasis
Introduction
Anticoagulant drugs
Antiplatelet agents
Thrombolytic drugs
Haemostatic and antifibrinolytic drugs
References
Online resource
14. Drugs affecting the haemopoietic system
Introduction
Haematinics
Haemopoietics
References
Online resources
Unit 5. Drugs Affecting the Respiratory System
15. Drugs used in respiratory disorders
Introduction: The respiratory system, respiratory disease and its treatment
Considerations for drug delivery to the airways: Drugs by inhalation
Medical gases
Respiratory stimulants and depressants
Drugs affecting secretions and mucociliary transport
Drugs affecting the nose
Drug treatment of asthma
Drug treatment of chronic obstructive pulmonary disease
Drugs used in respiratory tract infections
References
Online resources
Unit 6. Drugs Affecting the Gastrointestinal System
16. Drugs affecting the upper and lower gastrointestinal tract
Introduction: The gastrointestinal system, gastrointestinal disease and drugs affecting the gastrointestinal system
The upper gastrointestinal tract
The lower gastrointestinal tract
References
Online resources
Unit 7. Drugs Affecting the Urinary System
17. Drugs affecting the kidney and bladder
Introduction: The kidneys
Diuretics
Drugs for bladder dysfunction
References
Online resources
Unit 8. Drugs Affecting the Central Nervous System
18. Central nervous system overview and anaesthetics
Introduction: The central nervous system
General anaesthesia
Local anaesthesia
References
Online resources
19. Analgesics
Introduction
Pain management
Analgesic drugs
References
Online resources
20. Antianxiety, sedative and hypnotic drugs
Introduction: Sleep and anxiety
Sedatives, hypnotics and anxiolytics
Benzodiazepines
Other anxiolytic and sedative/hypnotic agents
References
Online resources
21. Antiepileptic drugs
Introduction: Epilepsy
Antiepileptic drug therapy
References
Online resources
22. Psychotropic agents
Introduction: Psychiatry and central nervous system neurotransmitters
Clinical aspects of drug therapy in psychiatry
Antipsychotic agents
Treating affective disorders
Lithium: The antimanic drug
References
Online resources
23. Central nervous system stimulants
Introduction: History and uses of stimulants
Amphetamines
Methylxanthines
References
Online resources
24. Drugs for neurodegenerative disorders and headache
Introduction
Drug treatment of movement disorders
Dementias, delirium and stroke
Drug treatment in migraine and other headaches
References
Online resources
25. Drug dependence and social pharmacology
Introduction
Drug abuse and dependence
Dependence on opioids
Central nervous system depressants
Central nervous system stimulants
Psychotomimetics
Other drugs of abuse
References
Online resources
Unit 9. Drugs Affecting the Endocrine System
26. The neuroendocrine system and pituitary gland
Introduction
Hormones as drugs
Neuroendocrine controls: Hypothalamic factors and related drugs
Anterior pituitary gland hormones and related drugs
Posterior pituitary gland hormones and related drugs
References
Online resources
27. The thyroid gland, the parathyroid glands and bone disorders
Introduction
Pharmacotherapy of thyroid disorders
Pharmacotherapy of parathyroid disorders
Pharmacotherapy of bone disorders
References
Online resources
28. The endocrine pancreas and diabetes mellitus
Introduction
Pancreatic hormones and diabetes
Management of type 2 diabetes
References
Online resources
29. The adrenal cortex and corticosteroids
Introduction
Glucocorticoids
Glucocorticoids used clinically
Mineralocorticoids
References
Online resources
Unit 10. Drugs Affecting the Reproductive System
30. Drugs affecting the female reproductive system
Introduction: Female reproductive system controls and hormones
Drugs used in gynaecological disorders
Contraception
Drugs during pregnancy, the perinatal period and lactation
Menopause and hormone replacement therapy
References
Online resources
31. Drugs affecting the male reproductive system
Introduction: Male reproductive system controls and hormones
Drugs used in male reproductive disorders
Contraception in males
Drugs that affect sexual functioning (male and female)
References
Online resources
Unit 11. Drugs Used in Neoplastic Diseases
32. Principles of cancer therapy
Introduction
Treatment of cancer
Clinical aspects of treating cancer
Roles of antineoplastic drugs
Molecular markers
Dosing
Adverse drug reactions
Treatment of adverse drug reactions
Development of drug resistance
Age-related considerations
Clinical trials of anticancer drugs
Special access schemes
Orphan drugs
References
33. Antineoplastic drugs
Cytotoxic antineoplastic drugs
Hormonal antineoplastic drugs
Non-cytotoxic antineoplastic drugs
Immunomodulatory drugs
Tumour vaccines
Adjunct therapies
Palliative care
References
Unit 12. Drugs Affecting Body Defences
34. Anti-inflammatory and immunomodulating drugs
Introduction
Non-steroidal anti-inflammatory drugs
Disease-modifying antirheumatic drugs
Immunosuppressant drugs
Immunostimulant drugs
Histamine and H1-antihistamines
Drugs used for the treatment of gout
References
Online resources
Unit 13. Drugs Affecting Microorganisms
35. Overview of antimicrobial chemotherapy and antibiotic resistance
Introduction
Antimicrobial therapy
Antibiotic resistance
Combating antimicrobial drug resistance
References
36. Antibacterial drugs
Introduction
Inhibitors of bacterial cell wall synthesis
Inhibitors of bacterial protein synthesis
Inhibitors of DNA synthesis
Miscellaneous antibiotics
Urinary tract antimicrobials
References
37. Antifungal and antiviral drugs
Treating fungal infections
Treating viral infections
Treating herpesviruses
Treating influenza and viral respiratory infection
Treating hepatitis B
Treating hepatitis C
Treating coronavirus
Treating human immunodeficiency virus
References
38. Antiprotozoal, antimycobacterial and anthelmintic drugs
Protozoal infections
Amoebiasis
Mycobacterial infections
Leprosy
Helminth infections
References
Unit 14. Special Topics
39. Drugs affecting the skin
Introduction
Application of drugs to the skin
Sunscreen preparations
Topical antimicrobial agents
Anti-inflammatory and immunomodulating agents
Retinoids and treatment of acne
Treatment of burns, pressure sores and skin ulcers
References
Online resources
40. Drugs affecting the eye and ear
Introduction
Drugs affecting the eye
Drugs affecting the ear
References
Online resources
41. Drugs in aged care
Introduction
Changes in pharmacodynamics and pharmacokinetics with ageing
Drug treatment for older adults
The impact of drugs on functional outcomes in older adults
Medication reviews and deprescribing
References
Online resources
42. Pharmacotherapy of obesity
Introduction
Health risks associated with obesity
Pathophysiology of obesity
Management of obesity
The future
References
Online resources
43. Vaccinations
Introduction
References
Online resources
44. Complementary medicines
Introduction
Complementary and alternative therapies
References
Online resources
Appendix 1: Abbreviations
Appendix 2: Glossary
Appendix 3: Common abbreviations and symbols used in prescriptions
Appendix 4: Dose calculation examples
Further readings
Figure list
Clinical focus box list
Drug monograph list
Figure and picture credits
Index

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Pharmacology for Health Professionals, 6e

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Kathleen Knights

Andrew Rowland

Shaunagh Darroch