Phage Therapy - Part A
- 1st Edition, Volume 200 - September 18, 2023
- Editor: Vijai Singh
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 6 3 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 6 4 - 5
Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in… Read more
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Request a sales quotePhage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform their research with great interest. Chapters in this new release cover An introduction to bacteriophage and their therapeutic applications, Isolation, screening and characterization of phage, Synthetic phage and their application in phage therapy, Phage engineering for development of diagnostic tools, Phage design and directed evolution to evolve phage for therapy, and more.
Additional sections cover Host-phage interactions and modelling for therapy, Phage and phage cocktails formulations, Phage for treatment of Escherichia coli infection, Phage for treatment of Klebsiella pneumoniae infection, Phage for treatment of Salmonella spp infection, Phage for treatment of Staphylococcus aureus infection, and Phages for treatment of Acinetobacter baumannii infection.
- Includes discussions on phage isolation, screening and characterization
- Covers synthetic phage, phage for diagnostic, directed evolution and host interaction
- Presents the latest on phage for treatment of bacterial infections
Basic researchers, Clinicians, Pharmacologists, students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Exploring the potential of phage and their applications
- Abstract
- 1 Introduction
- 2 Life cycle of phage
- 3 Applications of phage
- 4 Conclusion and future remarks
- Acknowledgements
- References
- Chapter Two: Isolation, screening and characterization of phage
- Abstract
- Abbreviations
- 1 Introduction
- 2 Become a phage-hunter: phage isolation
- 3 Phage characterization
- 4 Genomic characterization
- 5 Conclusion and future remarks
- References
- Further reading
- Chapter Three: Synthetic phage and its application in phage therapy
- Abstract
- 1 Introduction
- 2 Structure
- 3 Classification
- 4 Development of synthetic phage
- 5 Synthetic phages for substance redevelop
- 6 Synthetic phage library
- 7 Production synthetic phage parts from phage genomes
- 8 Application
- 9 Conflicts in phage remedy of synthetic phage
- 10 Conclusions
- 11 Future with synthetic phage
- References
- Chapter Four: Phage engineering for development of diagnostic tools
- Abstract
- 1 Introduction
- 2 Antibody-based diagnostic tests
- 3 Phage typing as diagnostic tool
- 4 Fluorescence phage-based detection methods
- 5 Bacteriophage as agents for signal amplification
- 6 Reporter phage engineering
- 7 Engineering platforms for phage genome editing
- 8 Conclusion and future prospects
- References
- Chapter Five: Phage design and directed evolution to evolve phage for therapy
- Abstract
- 1 Introduction
- 2 History
- 3 Mode of action
- 4 Selection of suitable phage for therapy
- 5 Pharmacology of phage therapy
- 6 Bacterial resistance to phages
- 7 Effects of phages in mammalian immune system
- 8 Directed evolution of phage for therapy
- 9 Conclusion
- References
- Chapter Six: Host-phage interactions and modeling for therapy
- Abstract
- 1 Introduction
- 2 Absorption
- 3 Interaction of phage with intracellular host proteins
- 4 Phage lysis of the host
- 5 Modeling for phage therapy
- 6 Conclusions
- References
- Chapter Seven: Phage and phage cocktails formulations
- Abstract
- 1 Introduction
- 2 Formulation of phage cocktails
- 3 Applications of phage cocktails
- 4 Conclusion and future perspectives
- Conflict of interest
- References
- Chapter Eight: Phages for treatment of Escherichia coli infections
- Abstract
- 1 Introduction
- 2 T4-related phages for E. coli therapy
- 3 Phage therapy of E. coli O157:H7
- 4 Phage therapy – HGT implications
- 5 Conclusions
- References
- Chapter Nine: Phages for treatment of Klebsiella pneumoniae infections
- Abstract
- Abbreviations
- 1 Introduction
- 2 Know your enemy: K. pneumoniae
- 3 Limitations of antibiotic therapy for K. pneumoniae infections
- 4 Phage therapy of K. pneumoniae
- 5 Conclusion
- References
- Chapter Ten: Phages for treatment of Salmonella spp infection
- Abstract
- 1 Introduction
- 2 Conventional treatment vs phage therapy
- 3 Rapid screening and detection methods associated with bacteriophage for Salmonella
- 4 Phages as a tool against Salmonella infections
- 5 Challenges in using phages
- 6 Future prospects
- 7 Conclusion
- Acknowledgments
- References
- Chapter Eleven: Phages for treatment of Staphylococcus aureus infection
- Abstract
- Abbreviations
- 1 Introduction
- 2 Identification, morphology and genomic characteristics of phages infecting S. aureus
- 3 Phage cocktail development against S. aureus
- 4 Established animal models for S. aureus phage therapy
- 5 Clinical trials for S. aureus phage therapy
- 6 Clinical cases of S. aureus phage treatments
- 7 Clinical Challenges of Phage Therapy against S. aureus
- 8 Conclusion
- References
- Chapter Twelve: Phage therapy for Acinetobacter baumannii infection
- Abstract
- 1 Introduction
- 2 Pathogenicity and strain resistance
- 3 Phage therapy
- 4 Acinetobacter baumannii phages resistance
- 5 Effect of A. baumannii phage on A. baumannii
- 6 Bacteriophage action and treatment for Acinetobacter species (phage therapy)
- 7 Phage therapy for multidrug resistant Acinetobacter baumannii
- 8 Conclusion
- References
- Index
- No. of pages: 300
- Language: English
- Edition: 1
- Volume: 200
- Published: September 18, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780323955638
- eBook ISBN: 9780323955645
VS
Vijai Singh
Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.
Affiliations and expertise
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, IndiaRead Phage Therapy - Part A on ScienceDirect