Phage Therapy - Part A

1st Edition, Volume 200 - September 18, 2023
Editor: Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 5 6 3 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 5 6 4 - 5

Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in… Read more

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Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform their research with great interest. Chapters in this new release cover An introduction to bacteriophage and their therapeutic applications, Isolation, screening and characterization of phage, Synthetic phage and their application in phage therapy, Phage engineering for development of diagnostic tools, Phage design and directed evolution to evolve phage for therapy, and more.

Additional sections cover Host-phage interactions and modelling for therapy, Phage and phage cocktails formulations, Phage for treatment of Escherichia coli infection, Phage for treatment of Klebsiella pneumoniae infection, Phage for treatment of Salmonella spp infection, Phage for treatment of Staphylococcus aureus infection, and Phages for treatment of Acinetobacter baumannii infection.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Exploring the potential of phage and their applications
Abstract
1 Introduction
2 Life cycle of phage
3 Applications of phage
4 Conclusion and future remarks
Acknowledgements
References
Chapter Two: Isolation, screening and characterization of phage
Abstract
Abbreviations
1 Introduction
2 Become a phage-hunter: phage isolation
3 Phage characterization
4 Genomic characterization
5 Conclusion and future remarks
References
Further reading
Chapter Three: Synthetic phage and its application in phage therapy
Abstract
1 Introduction
2 Structure
3 Classification
4 Development of synthetic phage
5 Synthetic phages for substance redevelop
6 Synthetic phage library
7 Production synthetic phage parts from phage genomes
8 Application
9 Conflicts in phage remedy of synthetic phage
10 Conclusions
11 Future with synthetic phage
References
Chapter Four: Phage engineering for development of diagnostic tools
Abstract
1 Introduction
2 Antibody-based diagnostic tests
3 Phage typing as diagnostic tool
4 Fluorescence phage-based detection methods
5 Bacteriophage as agents for signal amplification
6 Reporter phage engineering
7 Engineering platforms for phage genome editing
8 Conclusion and future prospects
References
Chapter Five: Phage design and directed evolution to evolve phage for therapy
Abstract
1 Introduction
2 History
3 Mode of action
4 Selection of suitable phage for therapy
5 Pharmacology of phage therapy
6 Bacterial resistance to phages
7 Effects of phages in mammalian immune system
8 Directed evolution of phage for therapy
9 Conclusion
References
Chapter Six: Host-phage interactions and modeling for therapy
Abstract
1 Introduction
2 Absorption
3 Interaction of phage with intracellular host proteins
4 Phage lysis of the host
5 Modeling for phage therapy
6 Conclusions
References
Chapter Seven: Phage and phage cocktails formulations
Abstract
1 Introduction
2 Formulation of phage cocktails
3 Applications of phage cocktails
4 Conclusion and future perspectives
Conflict of interest
References
Chapter Eight: Phages for treatment of Escherichia coli infections
Abstract
1 Introduction
2 T4-related phages for E. coli therapy
3 Phage therapy of E. coli O157:H7
4 Phage therapy – HGT implications
5 Conclusions
References
Chapter Nine: Phages for treatment of Klebsiella pneumoniae infections
Abstract
Abbreviations
1 Introduction
2 Know your enemy: K. pneumoniae
3 Limitations of antibiotic therapy for K. pneumoniae infections
4 Phage therapy of K. pneumoniae
5 Conclusion
References
Chapter Ten: Phages for treatment of Salmonella spp infection
Abstract
1 Introduction
2 Conventional treatment vs phage therapy
3 Rapid screening and detection methods associated with bacteriophage for Salmonella
4 Phages as a tool against Salmonella infections
5 Challenges in using phages
6 Future prospects
7 Conclusion
Acknowledgments
References
Chapter Eleven: Phages for treatment of Staphylococcus aureus infection
Abstract
Abbreviations
1 Introduction
2 Identification, morphology and genomic characteristics of phages infecting S. aureus
3 Phage cocktail development against S. aureus
4 Established animal models for S. aureus phage therapy
5 Clinical trials for S. aureus phage therapy
6 Clinical cases of S. aureus phage treatments
7 Clinical Challenges of Phage Therapy against S. aureus
8 Conclusion
References
Chapter Twelve: Phage therapy for Acinetobacter baumannii infection
Abstract
1 Introduction
2 Pathogenicity and strain resistance
3 Phage therapy
4 Acinetobacter baumannii phages resistance
5 Effect of A. baumannii phage on A. baumannii
6 Bacteriophage action and treatment for Acinetobacter species (phage therapy)
7 Phage therapy for multidrug resistant Acinetobacter baumannii
8 Conclusion
References
Index

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Phage Therapy - Part A

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Vijai Singh