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pH-Interfering Agents as Chemosensitizers in Cancer Therapy

  • 1st Edition, Volume 10 - September 3, 2020
  • Latest edition
  • Editors: Claudiu T. Supuran, Simone Carradori
  • Language: English

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from bioc… Read more

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Description

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field.

Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.

Key features

  • Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling
  • Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension
  • Discusses novel targets to explore new possibilities that enhance research in the field

Readership

Cancer researchers, medical scientists, clinicians, graduate students

Table of contents

PART I General overview of the topic: An update1. General introduction about general mechanisms of resistance in cancer (hypoxia, efflux pumps, tumoral microenvironment) and use of chemosensitizers in association with drugs already in the market2. Clinical studies analysis3. Combination therapy4. Oncoimmunology

PART II Chemosensitizing agents with a validated mechanism of action5. pH regulators of the tumoral microenvironment6. Proton Pump Inhibitors (PPIs) and other pH buffering agents7. Selective hCA IX and XII inhibitors8. Epigenetic modulators9. Photosensitizing agents10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil)11. Metalloproteinase inhibitors (e.g., ADAM17)12. Kinesin inhibitors13. Drug repurposing14. Innovative and putative targets for chemosensitizers15. Patent survey on chemosensitizers

PART III Chemosensitizing agents from natural sources16. Natural compounds as chemosensitizers: a lesson from plants17. Natural compounds: from food to clinic

PART IV Chemosensitizing agents: Computational tools and technological approaches18. Virtual screening and chemoinformatics of new library of chemosensitizers19. Nanostructures overcoming cancer resistance

Review quotes

"This book represents a relatively unique contribution to the current literature that addresses a topic of intense clinical interest and contemporary research. It does so in a concise and easily read package accessible to students and experts alike."—Doody

Product details

  • Edition: 1
  • Latest edition
  • Volume: 10
  • Published: September 3, 2020
  • Language: English

About the editors

CS

Claudiu T. Supuran

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.
Affiliations and expertise
Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, Italy

SC

Simone Carradori

Dr. Carradori is a very prolific researcher with papers dealing with both synthetic and natural products characterized by promising biological activities. Regarding this topic, he has been involved in the study of HAT inhibitors, hCA IX and XII inhibitors, kinesin Eg5 inhibitors and natural compounds active in the field of oncology. Recently, he has been focusing on “drug repurposing” disclosing a patent on new roles played by antiparasitic benzimidazoles as anti-cancer agents. He also was Co-Guest Editor of several special issues, co-author of chapters for two books (one edited by Elsevier) and acts as Editorial Board member of several peer-reviewed journals.
Affiliations and expertise
Assistant professor in Medicinal Chemistry, Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Italy

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