I. INTRODUCTION
1. Introduction - Henry deF. Webster
II. STRUCTURE OF THE PERIPHERAL NERVOUS SYSTEM
2. Gross Anatomy of the PNS – Ernest Gardner & Richard P. Bunge
(No change/will use PN3 version)
3. Microscopic Anatomy of the PNS - C.H. Berthold, J. Fraher & R. H. M. King
III. FUNCTION OF THE PERIPHERAL NERVOUS SYSTEM
4. Channel Function in Axons and Sheath Cells –S. Y. Chiu
5. Nerve Excitability Measures: Biophysical Basis and Use in the Investigation of Peripheral Nerve Disease - Matthew C. Kiernan, David Burke & Hugh Bostock
6. The Muscle Spindle - R. W. Banks
7. The Golgi Tendon Organ – J. Scott
8. The Peripheral Sensory Nervous System: Dorsal Root Ganglion Neurons – Sally N. Lawson
9. The Pupil - James J. Corbett
10.
11. Neurologic Control of Cardiac Function - David Paterson & John Coote
12. Neurobiology of Autonomic Peripheral Ganglia - David Kreulen
13. Neurobiology of the Enteric Nervous System - Jackie D. Wood
14. Autonomic and Somatic Systems to the Anorectum
and Pelvic Floors – Adil E. Bharucha & Christopher Klingele
15. Autonomic Systems to the Urinary Bladder & Sexual Organs - William C. de Groat & August M. Booth
16. Sympathetic nerves and control of blood vessels to human limbs - Michael J. Joyner, Paul M. VanHoutte, John R. Halliwill & John T. Shepherd
IV. NEUROBIOLOGY OF THE PERIPHERAL NERVE SYSTEM
17. Molecular Signaling in Schwann Cell Development - R. Mirsky & K. Jessen
18. Growth Factors of the PNS - Anthony Windebank
19. Axonal Flow - W. Stephen Brimijoin
20. Myelination – O. Suter & R. Martini
21. The Control of Axonal Caliber - John W. Griffin & Ahmet Hoke
22. Guidance of Axons to Targets in Development and in Disease – Frank Bradke
23. Aging of the PNS – T. Cowen & R.H.M. King
24. Oxidative Stress and Excitatory Neurotoxins - Phillip A. Low
25. Transgenic Models of Nerve Degeneration – R. Martini
V. NEUROIMMUNOLOGY OF THE PERIPHERAL NERVOUS SYSTEM
26. Introduction to Immune Reactions in the PNS - Hans-Peter Hartung, Guido Stoll & Klaus Toyka
27. Peripheral Nerve Antigens - Hugh J. Willison, Norman A. Gregson, Graham M. O’Hanlon & Richard A. C. Hughes
28. Experimental Autoimmune Neuritis (EAN) - Ralf Gold, Guido Stoll, Bernd C. Kieseier, Hans-Peter Hartung & Klaus Toyka
29. Fundamentals of Immune Therapy - J.D. Pollard, Richard Hughes & Peter Hartung
VI. FUNCTIONAL COMPARTMENTS AND NERVE-FIBER ENVIRONMENT
30. The Blood Nerve Barrier – Ananda Weerasuriya
31. Nerve Blood Flow and Nerve Fiber Microenvironment - Phillip McManis & Phillip A. Low
VII. PATHOLOGY
32. Pathology of Peripheral Neuron Cell Bodies - Michale J. Groves & Francesco Scaravilli
33. Pathologic Alterations of Nerves - Peter J. Dyck, P. J. B. Dyck & JaNean Engelstad
34. Pathology of the Neuromuscular Junction - Andrew G. Engel
35. Pathology and Quantitation of Cutaneous Innervation - William R. Kennedy, Justin C. McArthur, Michael J. Polydefkis & Gwen Wendelschafer
VIII. NERVE CONDUCTION AND ELECTROMYOGRAPHY
36. Nerve Conduction and Needle Electromyography - Jun Kimura
37. Nerve Tests Expressed as Percentiles, Normal Deviates and Composite Scores – Peter J. Dyck, Peter C. O’Brien, Jenny Davies, Christopher J. Klein & P. James B. Dyck
38. Single Fiber Electromyography - Erik Stålberg & J. Trontelj
39. Single-unit Recordings of Afferent Human Peripheral Nerves
by Microneurography – Erik Torebjörk & Martin Schmelz
40. Compound Action Potential of Sural Nerves in Vitro - Edward H. Lambert & Peter J. Dyck(No change/will use PN3 version)
IX. QUANTITATING SYMPTOMS, IMPAIRMENTS AND OUTCOMES
41. Quantitating Neuropathic Symptoms, Impairments
and Outcomes – Peter J. Dyck & Richard A. C. Hughes
42. Health Outcomes and Quality of Life - Ann Jakoby
43. Quantitation of Sensory Abnormality - Peter J. Dyck, Peter C. O’Brien, David M. Johnson
Christopher J. Klein & P. James B. Dyck
44. Quantitation of Muscle Contraction & Strength - Kenton R. Kaufman
45. Quantitation of Autonomic Impairment - Phillip Low & C.J. Mathias
X. DISEASES OF THE PERIPHERAL NERVOUS SYSTEM
Part A. Differential Diagnoses and Epidemiology
46. Clinical Patterns – Philip Thompson & P. K. Thomas
47. Differential Diagnoses of Polyneuropathy – Ian A. Grant, Timothy J. Benstead & Peter J. Dyck
48. Epidemiologic Approaches to Peripheral Neuropathy - James P. Burke & L. Joseph Melton, III
Part B. Diseases of Cranial Nerves
49. Diseases of the Third, Fourth, and Sixth Cranial Nerves - Jacqueline A. Leavitt & Brian R. Younge
50. Diseases of the Fifth Cranial Nerve – Richard A. C. Hughes
51. Diseases of the Seventh Cranial Nerve - Caroline M. Klein
52. Diseases of the Eighth Cranial Nerve - Linda M. Luxon & Doris Bamiou
53. Diseases of the Ninth, Tenth, Eleventh, and Twelfth Cranial Nerves – C. Mathias & P. K. Thomas
Part C. Diseases of Spinal Cord, Spinal Roots, and Limb Girdle Plexuses
54. Myelopathies Affecting Anterior Horn Cells and Centrally Directed Afferent Axons in Posterior
Horns and Columns – Caroline Klein & Annabel Wang
55. Diseases of Spinal Roots – Colin Chalk
56. Mechanical Compression, Traction, Electrical Radiation and Neoplastic Infiltration of the Brachial Plexus - Asa Wilbourne
57. Diseases of Spinal Cord, Spinal Roots, and Limb-Girdle Plexuses - Michael Donaghy
Part D. Neuropathy Due to Compression, Entrapment or Physical Injury
58. Mechanisms of Nerve Injury from Compression, Entrapment, Traction and Ischemia - Ted Burns & Peter J. Dyck
59. Mechanisms of Repair After Traumatic Injury - Susan Hall
60. Median Neuropathy – J. Clarke Stevens
61. Upper Limb Neuropathies: suprascapular, axillary, nerve to serratus anterior, radial and ulnar - Asa Wilbourne
62. Lower Limb Neuropathies – Asa Wilbourne
63. Operating on Peripheral Nerves – Rolfe Birch
Part E. Sporadic Motor Neuron Disease
64. Sporadic Motor Neuron Degeneration - Nigel Leigh
Part F. Basis of Inherited Disease
65. Mendelian and Mitochondrial Inheritance, Gene Identification, and Clinical Testing - Virginia V. Michels, Stephen N. Thibodeau & Erik C. Thorland
66. Transgenic Models of Inherited Neuropathy - Clare Huxley & Andrea Roberterson
Part G. Inherited Motor Neuron Degeneration
67. Transgenic Models of ALS – Eric Sorenson
68. Inherited Motor Neuron Degeneration – Nigel Leigh
69. Hereditary Motor Neuropathies (Spinal Muscular Atrophies) - Peter de Jonghe
Part H. Hereditary Motor and Sensory Neuropathies
70. Principles of Classifications, Clinical Syndromes - Michael Shy, Peter J. Dyck, Phillip F. Chance, James R Lupski & Christopher J. Klein
71. Disorders Related to PMP22 Mutations - James R. Lupski & Phillip F. Chance
72. The Hereditary Motor and Sensory Neuropathies (HMSN)
73. Related to MPZ (P0) Mutations – Michael E. Shy
74. Disorders Related to EGR 2 Mutations - Laura E. Warner & James R. Lupski
75. Molecular Genetics of HMSN II (CMT 2)- Christopher J. Klein & Peter J. Dyck
76. Hereditary Brachial Plexus Neuropathy - Christopher J. Klein & Anthony J. Windebank
77. Autosomal Recessive HMSN - Anneke Gabrёёls-Festen & P. K. Thomas
78. X-Linked HMSN – Steve Scherer
79. Multiple Endocrine Neoplasia, Type 2B – J. Aidan Carney
Part I. Hereditary Sensory and Autonomic Neuropathies
80. Clinical, Pathologic Classification, and Molecular Genetics - Christopher J. Klein, Robert H. Brown & Peter J. Dyck
Part J. Inborn errors of Metabolism With Peripheral Nerve Involvement
81. Lysosomal and Peroxisomal Disorders - P. K. Thomas & Hans Goebel
82. Porphyria - A. J. Windebank
83. Fabry Disease – Roscoe O. Brady & Raphael Schiffmann
84. Tangier Disease and Neuropathy – Mason Freeman & Gilmore O’Neill
85. Hereditary Amyloid Neuropathy – M. Reilly
86. Mitochondrial Disorders – Michael Hanna
Part K. Neuropathy Associated with Systemic Disease
87. Diabetic Polyneuropathy - P.K. Thomas, D. Tomlinson & G. Llewelyn
88. Diabetic Radiculoplexus Neuropathies - P. James B. Dyck & J. Clarke Stevens
89. Neuropathies Associated With Renal Failure, Hepatic Disorders, Chronic Respiratory Disease and Critical Illness – Douglas W. Zochodne
90. Neuropathy in Diseases of Thyroid and Pituitary Glands - John Pollard
Part L. Nutritional and Vitamin Deficiencies
91. Nutritional and Vitamin Deficiency – David Saperstein & Richard Barohn
92. Myeloneuropathies – Gustavo C. Roman
Part M. Infections
93. Leprosy - Thomas D. Sabin, Thomas R. Swift & Robert R. Jacobson
94. Lyme Borreliosis – Gerard Said
95. Herpes Simplex and Zoster - Donald Gilden & Kenneth Tyler
96. Peripheral Neuropathies in HIV Infection - Ahmet Hoke & David R. Cornblath
97. Diphtheritic Polyneuropathy – David Pleasure & Albee Messing
98. Parasitic Infections – Sudha Pottumarthy & Thomas Fritsche
Part N. Inflammatory and Immune
99. Antibodies to Nerve Components and Neuropathy - A. Pestronk & Glenn Lopate
100. AIDP – John W. Griffin
101. CIDP – Angelika F. Hahn, Hans-Peter Hartung & Peter J. Dyck
102. Neuropathy Associated with the Monoclonal Antibodies - Robert A. Kyle & Peter J. Dyck
103. Multifocal Motor Neuropathy and Persistent Conduction
Block – H. J. Willison & Bruce V. Taylor
104. Brachial Plexus Neuropathy - Guillermo A. Suarez
105. Nonmalignant Inflammatory Sensory Polyganglionopathy - Benn E. Smith, Anthony J. Windebank & Peter J. Dyck
106. Cryptogenic Sensory Polyneuropathy - Ian A. Grant
107. Neuropathies with Systemic Necrotizing Vasculitis - John T. Kissel & Jerry R. Mendell
108. Neuropathies and Microvasculitis – P. James B. Dyck
109. Sarcoid Neuropathy – Gerard Said & Catherine Lacroix
Part O. Peripheral Neuropathy Associated with Malignancy, etc.
110. Amyloidosis and Neuropathy - Robert A. Kyle, John J. Kelly & Peter J. Dyck
111. POEMS Syndrome (Osteosclerotic Myeloma)- Angela Dispenzieri & Guillermo A. Suarez & Robert A. Kyle
112. Paraneoplastic Neuropathy – James McLeod & J. Spies
113. Peripheral Neuropathy Associated with Lymphoma, Leukemia and Myeloproliferative Disorders - E. Peter Bosch, Thomas M. Habermann & Ayalew Tefferi
Part P. Neuropathy Associated With Industrial Agents, Metals and Drugs
114. Industrial Agents – Alan Berger & Herbert Schaumburg
115. Metal Neuropathy – A.J. Windebank
116. Pharmaceutical Agents – Steve Herskovitz & Herb Schaumberg
Part Q. Tumors
117. Peripheral Nerve Tumors – Caterinia Giannini
Part R. Management
118. Management with Acute Neuromuscular Disease in the Intensive Care Unit – Eelco Wijdicks
119. Physical Medicine & Rehabilitation – Mary Dombovy
120. Mechanisms and Pharmacologic Management of Neuropathic Pain - Michael C. Rowbotham
121. Management of Autonomic Failure – Phillip A. Low
122. Management of Cardiovascular Failure – Roy L. Freeman
123. Management of Gut Dysmotility - Michael Camilleri & Adil Bharucha
124. Peripheral Neuropathies in Infants and Children - Ted M. Burns, Monique M. Ryan, Basil T. Darras & H. Royden Jones