Perinatal Asphyxia: Moving the Needle, An Issue of Clinics in Perinatology

1st Edition, Volume 51-3 - August 7, 2024
Editor: Lina Chalak
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 0 0 9 - 0
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 0 1 0 - 6

In this issue of Clinics in Perinatology, guest editor Dr. Lina Chalak brings her considerable expertise to the topic of Perinatal Asphyxia: Moving the Needle. Top experts discu… Read more

Perinatal Asphyxia: Moving the Needle, An Issue of Clinics in Perinatology

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In this issue of Clinics in Perinatology, guest editor Dr. Lina Chalak brings her considerable expertise to the topic of Perinatal Asphyxia: Moving the Needle. Top experts discuss current clinical information on perinatal asphyxia, giving perinatologists they guidance they need to improve outcomes in newborns, while looking at results from clinical trials, neuroimaging biomarkers, and low-resource settings.

Cover image
Title page
Table of Contents
Copyright
Contributors
CME Accreditation Page
Forthcoming Issues
Foreword
Preface
Causes and Terminology in Neonatal Encephalopathy: What is in a Name? Neonatal Encephalopathy, Hypoxic-ischemic Encephalopathy or Perinatal Asphyxia
Key points
Introduction
Terminology
Summary
Neonatal Encephalopathy is a Complex Phenotype Representing Reproductive and Pregnancy Exposome Effects on the Maternal-Placental-Fetal Triad
Key points
Introduction
The exposome concept applied to fetal neonatal neurology
The reproductive exposome
The pregnancy exposome
The placental exposome
The neonatal exposome
The pediatric exposome
Investing in a brain capital strategy
Uncovering the Role of Inflammation with Asphyxia in the Newborn
Key points
Introduction
Summary
Reverse Therapy: Impact of Hyperthermia and Rewarming on Newborn Outcomes
Key points
Evidence from preclinical models
Clinical outcomes with hyperthermia following hypoxic-ischemic encephalopathy
Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy
Key points
Introduction
Evaluation of neonatal seizures
Neurodevelopmental outcomes following hypoxic-ischemic encephalopathy-associated neonatal seizures
Management of acute provoked neonatal seizures in hypoxic-ischemic encephalopathy
Summary
Hypothermia for Hypoxic-ischemic Encephalopathy: Second-generation Trials to Address Gaps in Knowledge
Key points
Introduction
Optimizing cooling trial
Late Hypothermia trial
Preterm hypothermia
Summary
A New Horizon for Understanding the Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy
Key points
Introduction
Methods
Summary
Key Inflammatory Biomarkers in Perinatal Asphyxia: A Comprehensive Review
Key points
Introduction
Pathophysiology of inflammation in perinatal asphyxia and role of biomarkers
Inflammatory biomarkers
Summary
Advances in Neuroimaging Biomarkers and Scoring
Key points
Introduction
Efficacy of MRI as a biomarker in perinatal asphyxia
Optimizing MRI in the neonatal intensive care unit
Optimizing MRI in therapeutic hypothermia protocols
Development of semiquantitative MRI analysis in perinatal hypoxic-ischemic encephalopathy: from then to now
Current advances in MRI biomarker technology
Future directions include further optimization of timing of neuroimaging after perinatal asphyxia
Summary
Advances in Electroencephalographic Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy
Key points
Introduction
Electroencephalographic biomarkers for grading the severity of encephalopathy
Electroencephalographic biomarkers of seizures in hypoxic ischemic encephalopathy
Electroencephalographic biomarkers of prognosis in hypoxic ischemic encephalopathy
Translation of neonatal electroencephalography biomarkers in the neonatal intensive care unit
Quantitative electroencephalography biomarkers
Machine learning and deep learning biomarkers
Summary
Moving the Needle in Low-Resource Settings: Is Hypothermia a Friend or a Foe?
Key points
Introduction
Clinical trials of induced hypothermia from high-income countries
Clinical trials of induced hypothermia in low-income and middle-income countries
Potential reasons for lack of hypothermic neuroprotection in the HELIX trial
Whole-body hypothermia in upper middle-income countries and affluent populations
National Neonatology Forum (India) guidelines
De-implementation of induced hypothermia
Whole-genome expression in hypoxic ischemic encephalopathy
HELIX hypothesis: the compromised baby in the womb
Collaborative neonatal neuroprotection trial platform in South Asia (CONNECTIONS)
Summary
Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy
Key points
Background
Outcomes
Summary
Communicating with Parents About Therapeutic Hypothermia and Hypoxic Ischemic Encephalopathy
Key points
Introduction
Day of birth: communicating amidst trauma
During hypothermia treatment: supporting the parent experience
MRI day: navigating prognostic uncertainty
Planning for discharge: facilitating shared decision making and the transition home
Summary
Disclosure
Ethical and Legal Perspectives on the Treatment of Hypoxic Ischemic Encephalopathy in the Newborn
Key points
Introduction
Discussion: ethical considerations
Discussion: legal considerations
Summary
Pipeline to Neonatal Clinical Transformation: The Importance of Preclinical Data
Key points
Introduction
Nature of the problem
Epidemiology of hypoxic-ischemic encephalopathy and gaps in knowledge
Erythropoietin as a potential neurotherapeutic
Preclinical models at a crossroads
Potential remedies and future directions

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Perinatal Asphyxia: Moving the Needle, An Issue of Clinics in Perinatology

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Lina Chalak