Perinatal and Neonatal Infections, An Issue of Clinics in Perinatology
- 1st Edition, Volume 52-1 - February 5, 2025
- Imprint: Elsevier
- Editors: Sagori Mukhopadhyay, Karen M. Puopolo
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 8 7 9 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 8 8 0 - 6
In this issue of Clinics in Perinatology, guest editors Drs. Sagori Mukhopadhyay and Karen M. Puopolo bring their considerable expertise to the topic of Perinatal and Neonatal… Read more
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Request a sales quoteIn this issue of Clinics in Perinatology, guest editors Drs. Sagori Mukhopadhyay and Karen M. Puopolo bring their considerable expertise to the topic of Perinatal and Neonatal Infections. Top experts review the fundamentals of neonatal infections and discuss the changing landscape of infectious disease and its management. Articles cover disease epidemiology, infection-related issues that have come into focus as neonatal practice evolves, the use of genomics to gain understanding of late-onset sepsis pathogenesis, consideration of circadian biology in infection transmission and acquisition, and more.
- Contains 13 practice-oriented topics including infection prevention 101; early onset sepsis and late onset sepsis; probiotic use in the NICU; neonatal-perinatal consequences of COVID-19 and emerging viral infections in the neonatal period; machine learning from EMR: warning systems for neonatal infections; and more
- Provides in-depth clinical reviews of perinatal and neonatal infections, offering actionable insights for clinical practice
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews
Perinatologists/Neonatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- CME Accreditation Page
- Foreword
- Preface
- Core Concepts
- Keeping Your Neonatal Intensive Care Unit Clean: The Hospital Environment as a Potential Source of Health Care-Associated Infections
- Key points
- Introduction
- Summary
- Neonatal Early-Onset Sepsis: Epidemiology, Microbiology, and Controversies in Practice
- Key points
- Introduction
- Epidemiology
- Microbiology
- Controversy 1: what are the pros and cons of intrapartum antibiotic prophylaxis?
- Controversy 2: given the persistent plateau in group B Streptococcus disease incidence and stable or increasing rates of E coli early-onset sepsis, are there opportunities for primary prevention, including maternal vaccination?
- Controversy 3: what is the optimal empiric treatment for suspected early-onset sepsis?
- Controversy 4: are there racial and ethnic disparities in early-onset sepsis?
- Disclaimer
- Funding
- Late-Onset Sepsis: Epidemiology, Microbiology, and Controversies in Practice
- Key points
- Introduction
- Epidemiology
- Clinical presentation
- Microbiology
- Controversies
- Summary
- Neonatal Invasive Fungal Infections: Epidemiology, Microbiology, and Controversies in Practice
- Key points
- Introduction
- Candida infections
- Invasive mold infections
- Disclosure
- Pharmacokinetic and Pharmacodynamic Approaches to Optimize Antibiotic Use in Neonates
- Key points
- Introduction
- Principles of pharmacokinetics
- Principles of pharmacodynamics
- Pharmacometric analysis
- Pharmacokinetics/pharmacodynamics data guiding neonatal antibiotic dosing
- Ampicillin
- Gentamicin
- Vancomycin
- Special circumstances
- Conclusions and future directions
- Disclosure
- Emerging Issues
- Probiotics and the Risk of Infection
- Key points
- Background
- Epidemiology of neonatal infection, including risk at early gestational ages
- Pathophysiology of neonatal infection, including the contribution of gut bacteria
- Probiotics and effects on outcomes in preterm infants, including infection
- Risks of infection associated with live bacteria in probiotic administered
- Risks of infection associated with contamination of probiotics
- Mitigating risks of probiotic-associated infection
- Summary
- Transplacental Antibodies: Role of Maternal Vaccines and Immunity
- Key points
- Introduction
- Physiology of transplacental antibody transfer
- Impairment of transplacental antibody transfer
- Maternal immunization and infant disease protection
- Summary
- Neonatal Cytomegalovirus Infection: Advocacy, Legislation, and Changing Practice
- Key points
- Epidemiology of maternal and congenital cytomegalovirus
- Clinical manifestations and diagnosis of congenital cytomegalovirus
- Screening for congenital cytomegalovirus
- Treatment of congenital cytomegalovirus
- The economic impact of congenital cytomegalovirus
- Cost-effectiveness of congenital cytomegalovirus targeted and universal screening
- Vaccines for the prevention of congenital cytomegalovirus
- Legislative efforts for congenital cytomegalovirus screening and education
- Summary
- Re-Thinking the Norms of Antibiotic Prescribing in the Neonatal Intensive Care Unit
- Key points
- Introduction
- Need for antibiotic stewardship: challenges with the existing status
- Impact of prolonged antibiotic exposure and adverse neonatal outcomes and beyond
- Impact on antibiotic resistance development
- Progress in neonatal antibiotic prescribing over the last decade
- Setting up of the antimicrobial stewardship team
- Knowing the baseline and benchmarking
- Audit-and-feedback
- Knowledge translation & implementation
- During evaluation for early onset sepsis
- During evaluation for late-onset sepsis
- During evaluation for ventilator-associated pneumonia
- Summary
- Future Perspectives
- Role of the Microbiome in Neonatal Infection: Pathogenesis and Implications for Management
- Key points
- Introduction
- Protective role of the microbiome against infection
- The microbiome as a reservoir for pathogens
- Interplay between risk factors for neonatal infection and determinants of neonatal microbiome
- Microbiome-based interventions to reduce infection
- Summary
- Clinics care points
- Machine Learning Models as Early Warning Systems for Neonatal Infection
- Key points
- Background
- Summary
- Disclosure
- Funding
- Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care
- Key points
- Introduction
- Edition: 1
- Volume: 52-1
- Published: February 5, 2025
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780443128790
- eBook ISBN: 9780443128806
SM
Sagori Mukhopadhyay
Affiliations and expertise
Assistant Professor of Pediatrics; Department of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, USAKP
Karen M. Puopolo
Affiliations and expertise
Professor of Pediatrics; Department of Pediatrics, ; Department of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, USA