Pediatric Respiratory Disease, An Issue of Clinics in Chest Medicine

1st Edition, Volume 45-3 - August 2, 2024
Editors: Erick Forno, Gregory Sawicki
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 0 0 3 - 8
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 0 0 4 - 5

In this issue of Clinics in Chest Medicine, guest editors Drs. Erick Forno and Gregory Sawicki bring their considerable expertise to the topic of Pediatric Respiratory Disease.… Read more

Pediatric Respiratory Disease, An Issue of Clinics in Chest Medicine

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In this issue of Clinics in Chest Medicine, guest editors Drs. Erick Forno and Gregory Sawicki bring their considerable expertise to the topic of Pediatric Respiratory Disease. Top experts discuss COVID-19 in pediatric populations; environmental exposures and pediatric respiratory disease; genetics and genomics in childhood respiratory diseases; microbiome and metabolome: their role in pediatric respiratory disease; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Outdoor Air Pollution and Pediatric Respiratory Disease
Key points
Introduction
Unique considerations of children
Common outdoor air pollutants
Modifiers of susceptibility to air pollution
Evidence for outdoor air pollution and incident respiratory disease
Evidence for outdoor air pollution exacerbating respiratory disease
Summary
Advances in Pediatric Lung Function Testing Techniques
Key points
Introduction
Multiple breath washout
Impulse oscillometry
Structured light plethysmography
Electrical impedance tomography
Principles of lung function interpretation
Advanced Diagnostic and Therapeutic Bronchoscopy in Pediatrics
Key points
Introduction
Advanced diagnostic procedures
Therapeutic procedures
Summary
Clinics care points
Imaging in Pediatric Lung Disease: Current Practice and Future Directions
Key points
Introduction
Small airway obstruction
Large airway obstruction
Bronchopulmonary dysplasia
Interstitial lung disease
Neuromuscular conditions
Congenital and pulmonary vascular abnormalities
Pulmonary infections
New frontiers in structural and functional imaging
Summary
Clinics care points
Supplementary data
The Role of the Microbiome in Pediatric Respiratory Diseases
Key points
Introduction
Brief overview of the methods used in microbiome research
The role of the microbiome in selected pediatric respiratory diseases
Future directions
Summary
Asthma—Genomic Advances Toward Risk Prediction
Key points
Introduction
Strategies for genetic mapping in human diseases
Genetic variation associated with asthma
Gene and variant prioritization of genetic associations with asthma
Disease risk prediction using genomics
Limitations
Summary
Clinics care points
Funding
Contributors
Current Practices in Pediatric Asthma Care
Key points
Introduction
Prevalence
Pathophysiology
Diagnosis
Summary
Clinics care points
Advances in Care and Outcomes for Children with Cystic Fibrosis
Key points
The changing epidemiology of cystic fibrosis
Diagnostic criteria and considerations
Principles of clinical care
Challenges in Pediatric Cystic Fibrosis Care
Summary
Clinics care points
Bronchopulmonary Dysplasia
Key points
Introduction
Epidemiology
Pathogenesis
Imaging
Sleep
Outpatient management
Adult complications
Summary
Clinics care points
Grant support
Advances in Sleep-Disordered Breathing in Children
Key points
Introduction
Genetics of pediatric obstructive sleep apnea
Diagnosis of obstructive sleep apnea
Biomarkers of pediatric obstructive sleep apnea
Surgical management of pediatric obstructive sleep apnea
Optimizing continuous positive airway pressure therapy and novel non-surgical therapeutics for the management of obstructive sleep apnea
Pediatric obstructive sleep apnea- A challenge for adult sleep specialists
Summary
Clinics care points
Congenital Central Hypoventilation Syndrome and Disorders of Control of Ventilation
Key points
Introduction
Congenital central hypoventilation syndrome
Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome
Prader-Willi Syndrome
Myelomeningocele and Chiari Malformation
Summary
Clinics care points
COVID-19 in Pediatric Populations
Key points
Risk factors for severe pediatric COVID-19
Pediatric protection against severe COVID-19
SARS-CoV-2: similarities and differences with other common pediatric viruses
Post-COVID-19 illnesses in children
Vaccination against COVID-19 in children
Summary
Clinics care points
Funding statement
Pulmonary Hypertension in Children
Key points
Introduction
Epidemiology: pulmonary hypertension is a disease with high global burden
Classification and hemodynamic profile of pulmonary hypertension in children
Diagnostic approach to the child suspected to have pulmonary hypertension
Treatment approaches
Management over time
Summary
Clinics care points
Innovations in Childhood Interstitial and Diffuse Lung Disease
Key points
Introduction
Presentation and diagnostic evaluation of childhood interstitial and diffuse lung disease
Current childhood interstitial and diffuse lung disease diagnostic categories
Neuroendocrine cell hyperplasia of infancy
Pulmonary interstitial glycogenosis
ChILD associated with inborn errors of immunity, autoimmune disorders, and connective tissue disorders
Bronchiolitis obliterans
Genetic childhood interstitial and diffuse lung disease disorders
Advances in multidisciplinary care of patients with childhood interstitial and diffuse lung disease
Treatment innovations
Imaging innovations
Research networks and family foundations
Patient registries
Future directions
Clinics care points
Respiratory Aspects of Primary Ciliary Dyskinesia
Key points
Introduction
The role of cilia in the respiratory pathophysiology of primary ciliary dyskinesia
Chronic airway inflammation in primary ciliary dyskinesia
Primary ciliary dyskinesia phenotype
Primary ciliary dyskinesia diagnostic tools
Primary ciliary dyskinesia sino-oto-pulmonary complications and management
Future directions
Summary
Clinics care points
Neuromuscular Disorders in Pediatric Respiratory Disease
Key points
Introduction
Neuromuscular respiratory function
Respiratory mechanical changes in neuromuscular disease
Routine clinical evaluation and diagnostic testing for children with neuromuscular disease
Sleep disordered breathing in NMD
Clinical evaluation of SDB in NMD
Diagnosis of sleep disordered breathing in NMD
Noninvasive mask ventilation for SDB in NMD
Noninvasive mouthpiece ventilation for SDB in NMD
Considerations for invasive ventilation for NMD
Overview of the use of home ventilation for children with NMD
Weak cough and pulmonary exacerbations in NMD
Pulmonary clearance in NMD
Disease modifying agents in NMD
Summary
Clinics care points
Financial disclosure
Funding
Updates in Pediatric Sickle Cell Lung Disease
Key points
Introduction
Acute chest syndrome
Lower airway disease
Sleep-disordered breathing and hypoxemia
Pulmonary vascular complications
Effects of the exposome on sickle cell disease lung disease
Emerging sickle cell disease therapies and lung outcomes
Summary
Clinics care points
Pediatric Lung Transplantation for Pulmonary Vascular Diseases: Recent Advances and Challenges
Key points
Introduction and background
Pulmonary vascular diseases
Considerations at transplant referral and listing
Bridging
Lung allocation score versus composite allocation score
Contraindications to transplantation
Types of transplant
Complications of transplantation
Outcomes
Summary
Clinics care points
Funding source
Financial disclosure
Advocacy and Health Equity: The Role of the Pediatric Pulmonologist
Key points
Introduction
The air kids breathe: climate change and advocating for environmental justice
Advocacy example(s)
The neighborhoods where kids grow and play: effects of neighborhood divestment and housing instability on adverse respiratory outcomes
Advocacy examples
Tobacco use and exposure among youth: focus on vaping prevention and cessation
Advocacy examples
Access matters: insurance and its impact on medication and equipment coverage
Advocacy examples
Technology: understanding its role in telemedicine, health literacy, and access
Advocacy examples
Advocacy: a building block for a career in pediatric pulmonology
Summary
Clinics care points

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Pediatric Respiratory Disease, An Issue of Clinics in Chest Medicine

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Erick Forno

Gregory Sawicki