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Elsevier

Pediatric Reference Intervals

  • 9th Edition - June 1, 2027
  • Latest edition
  • Authors: Edward C.C. Wong, Mark Kellogg, Khosrow Adeli, Mary Kathyrn Bohn, Alexandra Elizabeth Kovach, Jose Carlo Jara Aguirre
  • Language: English

Pediatric Reference Intervals, 9th Edition is an essential resource for clinical chemists, laboratorians, hematologists, pathologists, endocrinologists, and pediatricians. It add… Read more

Description

Pediatric Reference Intervals, 9th Edition is an essential resource for clinical chemists, laboratorians, hematologists, pathologists, endocrinologists, and pediatricians. It addresses the critical need for accurate pediatric reference intervals, which differ significantly from adults due to physiological changes during growth and vary with testing methodologies and instrumentation. This ninth edition updates and compiles the most current pediatric reference intervals from peer-reviewed studies since 2021, facilitating quick and reliable verification or establishment of reference intervals in laboratories. Organized alphabetically by analyte, it provides standardized formatting, details on methodology, sample types, study populations, and statistical bases, enabling users to assess relevance to their own institutions. Unlike competing texts, it offers comprehensive coverage of over 250 analytes with multiple methodologies and populations. The book enhances interpretation of pediatric test results, supports comparison across methods, and optimizes patient care.

Key features

  • Provides the reference intervals for a wide variety of analytes for children, from neonates to adolescents to young adults
  • Presents enhanced interpretation of patient results, allowing comparison of test results using different methods and optimization of patient care
  • Expands the coagulation section by inclusion of key analytes involved in fibrinolytic cascade
  • Provides the reference intervals for a wide variety of analytes for children, from neonates to adolescents to young adults
  • Presents enhanced interpretation of patient results, allowing comparison of test results using different methods and optimization of patient care
  • Offers new reference intervals in point-of-care testing for glucose tests and viscoelastic hematology testing, essential trace and toxic elements, using high-resolution and triple quadrupole inductively coupled plasma mass spectroscopy
  • Includes clinical decision limits that have been advocated by key medical societies and organizations

Readership

Pathology, Laboratorians, Pediatrics/Neonatalogy, Endocrinology, Hematology/Coagulation

Table of contents

1. Introduction

2. Chemistry tests

3. Hematology tests

4. Coagulation tests

Review quotes

Review of the previous edition:
"If you perform laboratory testing for pediatric populations and consult with pediatricians, get this book now."—Doody

Product details

  • Edition: 9
  • Latest edition
  • Published: June 1, 2027
  • Language: English

About the authors

Edward C.C. Wong

Author
Edward Wong FCAP is Medical Director, Coagulation, Quest Diagnostics Nichols Institute; Adjunct Associate Professor in Pediatrics and Pathology, George Washington School of Medicine and Health Sciences, Clinical Consultant at Children’s National Hospital in the Divisions of Pathology and Laboratory Medicine; and Hematology, Washington DC, USA
Affiliations and expertise
Medical Director, Coagulation/Blood Bank, Quest Diagnostics/Nichols Institute, Chantilly, VA, USA

Mark Kellogg

Author
Dr. Mark David Kellogg, Assistant Professor of Pathology at Harvard Medical School and Associate Director of Chemistry in the Department of Laboratory Medicine at Boston Children’s Hospital. With a PhD in Biology from the University of Notre Dame and a fellowship in Clinical Chemistry at Boston Children’s Hospital, Dr. Kellogg has over three decades of experience in clinical laboratory science, research, and education. He has held leadership roles including Co-Director of the Clinical Chemistry Fellowship Program and Director of Quality Programs at Boston Children’s Hospital, as well as Director of Clinical Laboratory at Claritas Genomics. Dr. Kellogg is active in professional organizations such as the American Association of Clinical Chemistry, Clinical Laboratory Standards Institute, and Academy of Clinical Laboratory Physicians and Scientists. He has published extensively on biochemical analyte measurement, clinical assay validation, and biomarker development. He is mentor, leading clinical chemistry training contributing to national and international laboratory standards.
Affiliations and expertise
Assistant Professor, Department of Pathology, Harvard Medical School, Boston, USA; Associate Director of Chemistry, Department of Laboratory Medicine, Boston Children's Hospital, Boston, USA

Khosrow Adeli

Author
Dr. Khosrow Adeli is a distinguished leader in clinical biochemistry and pediatric laboratory medicine, serving as Division Head at SickKids since 1988 and Director of its Point of Care Testing Program since 2001. He is Vice Chair of Quality at the University of Toronto’s Laboratory Medicine and Pathobiology department and served as President of the International Federation of Clinical Chemistry & Laboratory Medicine (IFCC) from 2020 to 2023. His research focuses on the pathophysiology of obesity, metabolic syndrome, and type 2 diabetes, particularly neuroendocrine regulation of lipoprotein metabolism via the gut-brain-liver axis. He leads the CALIPER project, establishing pediatric reference intervals widely used in clinical practice globally. Dr. Adeli has published over 600 articles and abstracts, and his work has been recognized with multiple prestigious awards for research, innovation, and teaching excellence.
Affiliations and expertise
Division Head, Clinical Biochemistry, SickKids, Toronto, Canada; Vice Chair of Quality, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

Mary Kathyrn Bohn

Author
Dr. Mary Kathryn Bohn is a clinical biochemist specializing in pediatric and maternal laboratory medicine. She earned her PhD from the University of Toronto’s Department of Laboratory Medicine and Pathobiology, focusing on physiological variation in biomarkers during growth, development, and pregnancy through the CALIPER initiative. Her research includes pediatric reference intervals, COVID-19 serology in children, and national reference interval harmonization. Dr. Bohn has authored over 55 peer-reviewed publications and presented extensively at international conferences. Currently a Clinical Chemistry Postdoctoral Fellow at the University of Toronto and Unity Health Toronto, she leads projects in immunology, point-of-care testing, and quality improvement. She actively contributes to professional working groups such as the IFCC Task Force on Global Reference Interval Database and the Canadian Society for Clinical Chemists. Recipient of the 2024 ADLM George Grannis Award for Research Excellence, Dr. Bohn is recognized for advancing laboratory standards to improve clinical diagnostics and patient care
Affiliations and expertise
Clinical Biochemist, Department of Laboratory Medicine, Unity Health Toronto

Alexandra Elizabeth Kovach

Author

Dr. Alexandra E. Kovach, MD, is the Director of Flow Cytometry and the Co-Director of Hematology and Coagulation at Boston Children’s Hospital. She earned her MD with special qualification in biomedical research from Cleveland Clinic Lerner College of Medicine and post-graduate training in Pathology at Massachusetts General Hospital and Boston Children’s Hospital. She is board-certified in Anatomic and Clinical Pathology, Hematopathology, and Pediatric Pathology. Her clinical, academic and educational activities are focused on the pathobiology, diagnosis, and monitoring of hematologic conditions in children and adolescents/young adults. She leads multiple clinical and translational research projects, has authored numerous peer-reviewed publications and book chapters, serves on editorial boards of key hematopathology journals, and is a co-chair of the College of American Pathologists (CAP) guideline on measurable residual disease (MRD) in B-lymphoblastic leukemia (B-ALL).

Affiliations and expertise
Director of Flow Cytometry and Co-Director of Hematology and Coagulation, Boston Children's Hospital, Boston, USA

Jose Carlo Jara Aguirre

Author
Dr. Jose Carlo Jara Aguirre, MD, is an Assistant Professor of Pathology and Pediatrics at The George Washington University School of Medicine and Health Sciences and Medical Director of Core Clinical Chemistry, Point of Care Testing, Special Chemistry, and Biocontainment Laboratory at Children’s National Hospital in Washington, DC. He earned his MD and MSc in Biochemistry from Universidad Peruana Cayetano Heredia, Peru, and completed a Clinical Pathology residency and research fellowship at Mayo Clinic. Dr. Jara Aguirre has extensive experience in clinical laboratory management, quality assurance, and laboratory medicine. He has authored numerous peer-reviewed publications and presented widely at national and international conferences. He actively contributes to professional societies including ADLM/AACC, CAP, CLSI, and IFCC, and serves on committees advancing laboratory standards and education. Dr. Jara Aguirre is recognized for his leadership in clinical chemistry education, mentoring, and global laboratory quality initiatives,
Affiliations and expertise
Assistant Professor, Departments of Pathology and Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, USA; Medical Director, Core Clinical Chemistry, Point of Care Testing, Special Chemistry, and Biocontainment Laboratory, Children's National Hospital, Washington, USA