Pediatric Liver Disease, An Issue of Clinics in Liver Disease

Cover image

Title page

Table of Contents

Copyright

Contributors

Forthcoming Issues

Preface

Biliary Atresia in Children: Update on Disease Mechanism, Therapies, and Patient Outcomes

Key points

Introduction

Definition and diagnosis of biliary atresia

Pathophysiology of disease onset and progression

Therapeutic options

Predicting prognosis in biliary atresia

Patient outcomes

Summary

Clinics care points

Financial support

Alagille Syndrome: Current Understanding of Pathogenesis, and Challenges in Diagnosis and Management

Key points

Introduction

Clinics care points

Overview of Progressive Familial Intrahepatic Cholestasis

Key points

Introduction

Discussion

Summary

Clinics care points

Alpha-1 Antitrypsin Deficiency Liver Disease

Key points

Introduction

Summary

Clinics care points

Hepatitis B and C in Children

Key points

Introduction

Hepatitis B

Hepatitis C

Summary

Clinics care points

Mitochondrial Hepatopathy

Key points

Introduction

Mitochondrial structure and function

Diagnostic evaluation

Clinical phenotypes

Treatment

Prognosis

Summary

Clinics care points

Nonalcoholic Steatohepatitis in Children

Key points

Introduction

Clinics care points

Conflicts of interest

An Update on Pediatric Acute Liver Failure: Emerging Understanding of the Impact of Immune Dysregulation and Novel Opportunities for Intervention

Key points

Introduction

The pediatric acute liver failure study group

Recent insights into the nature of indeterminate pediatric acute liver failure

Emerging understanding of the role of immune dysregulation in indeterminate pediatric acute liver failure

Treatment for immune mediated pathophysiology in pediatric acute liver failure: the TRIUMPH study

Summary

Wilson Disease in Children

Key points

Introduction

Copper metabolism

Pathogenesis

Clinical features

Diagnosis

Genetic diagnosis and counseling

Scoring systems

Treatment

Liver transplantation

New therapies

Summary

Clinics care points

Disclosure

Recent Insights into Pediatric Primary Sclerosing Cholangitis

Key points

Definition and epidemiology

Cause and pathogenesis

Patient presentation, disease phenotypes, and diagnosis

Natural history, complications, and outcomes

Current treatment modalities

Prognosis and prognostic tools

Summary

Clinics care points

Pediatric Liver Transplantation

Key points

Introduction

Indications for liver transplant

Allocation

Liver transplant evaluation

Surgical techniques and variant transplants

Medications

Outcomes and complications

Long-term management

Adherence and transition

Clinics care points

Fat Soluble Vitamin Assessment and Supplementation in Cholestasis

Key points

Introduction

Vitamin A

Vitamin E

Vitamin D

Vitamin K

Practical approach to management of fat-soluble vitamin deficiency in cholestasis

Summary