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Pathophysiology
- 6th Edition - January 17, 2018
- Author: Jacquelyn L. Banasik
- Language: English
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 5 1 0 4 2 - 4
Develop a strong understanding of pathophysiology. Pathophysiology, 6th Edition explores the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disor… Read more
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Request a sales quoteDevelop a strong understanding of pathophysiology. Pathophysiology, 6th Edition explores the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders. Each section focuses on the major alterations in the homeostasis of the body systems in order to provide you with a unifying framework. Current scientific findings and relevant global research are integrated throughout the book, with chapters organized by body system, beginning with an illustrated review of anatomy and normal physiology. Each chapter includes a discussion on the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Written by leading educators, this text simplifies a rigorous subject with practical learning resources, an emphasis on critical thinking, and coverage of the latest scientific findings and relevant research. Plus, more than 1,000 updated, full color illustrations and photos throughout, give you a chance to visualize disease and disease processes and gain a clearer understanding of the material.
- Easy-to-read style is simplified by input from readability experts, and includes many tables, boxes, and figures to highlight key content.
- Student-friendly learning resources in the text include chapter outlines, bolded key terms, key questions, Key Points boxes, and chapter summaries.
- Pediatric and Geriatric Considerations boxes include brief analyses of age-related changes associated with specific body systems.
- A comprehensive glossary defines terms and includes audio pronunciations on the Evolve companion website.
- Cover image
- Title Page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Reviewers
- Preface
- Organization
- Features
- Ancillaries
- Acknowledgments
- Unit I Pathophysiologic Processes
- 1 Introduction to Pathophysiology
- Framework for Pathophysiology
- Concepts of Normality in Health and Disease
- Patterns of Disease in Populations
- Summary
- Resources
- 2 Homeostasis, Allostasis, and Adaptive Responses to Stressors
- Homeostasis and Allostasis
- Stress as a Concept
- Neurohormonal Mediators of Stress and Adaptation
- Adaptation, Coping, and Illness
- Summary
- Resources
- Unit II Cellular Function
- 3 Cell Structure and Function
- Plasma Membrane
- Organization of Cellular Compartments
- Cellular Metabolism
- Functions of the Plasma Membrane
- Intercellular Communication and Growth
- Summary
- Resources
- 4 Cell Injury, Aging, and Death
- Reversible Cell Injury
- Cellular Adaptation
- Irreversible Cell Injury
- Etiology of Cellular Injury
- Cellular Aging
- Somatic Death
- Summary
- Resources
- 5 Genome Structure, Regulation, and Tissue Differentiation
- Structure and Function of DNA
- Regulation of the Genome
- Differentiation of Tissues
- Summary
- Resources
- 6 Genetic and Developmental Disorders
- Genetic Disorders
- Resources
- 7 Neoplasia
- Benign Versus Malignant Growth
- Epidemiology and Cancer Risk Factors
- Genetic Mechanisms of Cancer
- Multistep Nature of Carcinogenesis
- Metastasis
- Effects of Cancer on the Body
- Cancer Therapy
- Summary
- Resources
- Unit III Defense
- 8 Infectious Processes
- Host–Microbe Relationship
- Transmission of Infection
- Types of Pathogenic Organisms
- Summary
- Resources
- 9 Inflammation and Immunity
- Components of the Immune System
- Innate Defenses and Inflammation
- Specific Adaptive Immunity
- Reference
- Integrated Function and Regulation of the Immune System
- Resources
- 10 Alterations in Immune Function
- Excessive Immune Responses
- Deficient Immune Responses
- Summary
- Resources
- 11 Malignant Disorders of White Blood Cells
- Classification of Hematologic Neoplasms
- Etiology of Myeloid and Lymphoid Neoplasms
- General Principles of Management
- Myeloid Neoplasms
- Lymphoid Neoplasms
- Summary
- Resources
- 12 HIV Disease and AIDS
- Epidemiology
- Etiology
- Pathogenesis
- Diagnostic Testing
- Monitoring the Progression of HIV
- Clinical Manifestations
- Treatment
- Summary
- Resources
- Unit IV Oxygen Transport, Blood Coagulation, Blood Flow, and Blood Pressure
- 13 Alterations in Oxygen Transport
- Composition of Blood
- Structure and Function of Red Blood Cells
- Gas Transport and Acid–Base Balance
- Anemia
- Anemia Related to Decreased Red Cell Production
- Anemia Related to Inherited Disorders of the Red Cell
- Anemia Related to Extrinsic Red Cell Destruction or Loss
- Transfusion Therapy
- Polycythemia
- Summary
- Resources
- 14 Alterations in Hemostasis and Blood Coagulation
- The Process of Hemostasis
- Evaluation of Hemostasis and Coagulation
- Vascular and Platelet Disorders
- Coagulation Disorders
- Summary
- Resources
- 15 Alterations in Blood Flow
- Organization of the Circulatory and Lymphatic Systems
- Principles of Flow
- Control of Flow
- General Mechanisms That Cause Altered Flow
- Alterations in Arterial Flow
- Alterations in Venous Flow
- Alterations in Lymphatic Flow
- Summary
- Resources
- 16 Alterations in Blood Pressure
- Arterial Blood Pressure
- Mechanisms of Blood Pressure Regulation
- Hypertension
- Low Blood Pressure
- Summary
- Resources
- Unit V Cardiac Function
- 17 Cardiac Function
- Cardiovascular Anatomy
- Cardiac Cycle
- Coronary Circulation
- Cardiac Myocytes
- Molecular Basis of Contraction
- Cardiac Energy Metabolism
- Cardiac Electrophysiology
- Electrocardiography
- Determinants of Cardiac Output
- Endocrine Function of the Heart
- Tests of Cardiac Function
- Summary
- Resources
- 18 Alterations in Cardiac Function
- Coronary Heart Disease
- Endocardial and Valvular Diseases
- Myocardial Diseases
- Pericardial Diseases
- Congenital Heart Diseases
- Summary
- Resources
- 19 Heart Failure and Dysrhythmias
- Heart Failure
- Cardiac Dysrhythmias
- Summary
- Resources
- 20 Shock
- Pathogenesis of Shock
- Types of Shock
- Assessment and Hemodynamic Monitoring
- Complications of Shock
- Summary
- Resources
- Unit VI Respiratory Function
- 21 Respiratory Function and Alterations in Gas Exchange
- Functional Anatomy
- Ventilation
- Pulmonary Blood Flow
- Diffusion and Transport of Respiratory Gases
- Alterations in Pulmonary Function
- Diagnostic Tests
- Alterations in Pulmonary Vasculature
- Pulmonary Malignancies
- Summary
- Resources
- 22 Obstructive Pulmonary Disorders
- Obstruction From Conditions in the Wall of the Lumen
- Obstruction Related to Loss of Lung Parenchyma
- Obstruction of the Airway Lumen
- Summary
- Resources
- 23 Restrictive Pulmonary Disorders
- Lung Parenchyma Disorders
- Atelectatic Disorders
- Pleural Space Disorders
- Neuromuscular, Chest Wall, and Obesity Disorders
- Infection or Inflammation of the Lung
- Summary
- Resources
- Unit VII Fluid, Electrolyte, and Acid-Base Homeostasis
- 24 Fluid and Electrolyte Homeostasis and Imbalances
- Body Fluid Homeostasis
- Fluid Imbalances
- Principles of Electrolyte Homeostasis
- Electrolyte Imbalances
- Summary
- Resources
- 25 Acid–Base Homeostasis and Imbalances
- Acid–Base Homeostasis
- Acid–Base Imbalances
- Summary
- Resources
- Unit VIII Renal and Bladder Function
- 26 Renal Function
- Renal Anatomy
- Overview of Nephron Structure and Function
- Regulation of Glomerular Filtration
- Transport Across Renal Tubules
- Regulation of Blood Volume and Osmolality
- Endocrine Functions
- Age-Related Changes in Renal Function
- Tests of Renal Structure and Function
- Summary
- Resources
- 27 Intrarenal Disorders
- Common Manifestations of Kidney Disease
- Congenital Abnormalities
- Neoplasms
- Infection
- Obstruction
- Glomerular Disorders (Glomerulopathies)
- Summary
- Resources
- 28 Acute Kidney Injury and Chronic Kidney Disease
- Acute Kidney Injury
- Chronic Kidney Disease
- Clinical Management
- Summary
- Resources
- 29 Disorders of the Lower Urinary Tract
- Lower Urinary Tract
- Lower Urinary Tract Symptoms and Syndromes
- Neurogenic Bladder
- Congenital Disorders
- Neoplasms
- Inflammation and Infection
- Obstruction
- Summary
- Resources
- Unit IX Genital and Reproductive Function
- 30 Male Genital and Reproductive Function
- Anatomy
- Embryology
- Male Reproductive Physiology
- Summary
- Resources
- 31 Alterations in Male Genital and Reproductive Function
- Disorders of the Penis and Male Urethra
- Disorders of the Scrotum and Testes
- Disorders of the Prostate
- Summary
- Resources
- 32 Female Genital and Reproductive Function
- Reproductive Structures
- Menstrual Cycle
- Breast
- Pregnancy
- Menopause
- Summary
- Resources
- 33 Alterations in Female Genital and Reproductive Function
- Menstrual Disorders
- Alterations in Uterine Position and Pelvic Support
- Inflammation and Infection of the Female Reproductive Tract
- Benign Growths and Aberrant Tissue of the Female Reproductive Tract
- Cancer of the Female Genital Structures
- Disorders of Pregnancy
- Disorders of the Breast
- Summary
- Resources
- 34 Sexually Transmitted Infections
- Urethritis, Cervicitis, Salpingitis, and Pelvic Inflammatory Disease
- Diseases With Systemic Involvement
- Diseases With Localized Lesions
- Enteric Infections
- Summary
- Resources
- Unit X Gastrointestinal Function
- 35 Gastrointestinal Function
- Structure and Organization of the Gastrointestinal Tract
- Gastrointestinal Motility
- Secretory Function
- Digestion and Absorption
- Gastrointestinal Function Across the Life Span
- Summary
- Resources
- 36 Gastrointestinal Disorders
- Disorders of the Mouth and Esophagus
- Alterations in the Integrity of the Gastrointestinal Tract Wall
- Alterations in Motility of the Gastrointestinal Tract
- Neoplasms of the Gastrointestinal Tract
- Summary
- Resources
- 37 Alterations in Function of the Gallbladder and Exocrine Pancreas
- Structure and Function of the Pancreaticobiliary System
- Embryology of the Pancreaticobiliary System
- Physiology of Bile
- Functional Anatomy of the Pancreas
- Disorders of the Gallbladder
- Disorders of the Pancreas
- Summary
- Resources
- 38 Liver Diseases
- Structure and Function of the Liver
- General Manifestations of Liver Disease
- Disorders of the Liver
- Cirrhosis
- Toxic Liver Disorders
- Other Structural Liver Conditions
- Transplantation
- Age-Related Liver Disorders
- Liver Diseases and Geriatric Considerations
- Summary
- Resources
- Unit XI Endocrine Function, Metabolism, and Nutrition
- 39 Endocrine Physiology and Mechanisms of Hypothalamic-Pituitary Regulation
- Hormone Structure and Action
- Hormone Regulation
- Hypothalamic-Pituitary Endocrine System
- Thyroid Hormones
- Steroid Hormones
- Categories of Endocrine Disease
- Summary
- Resources
- 40 Disorders of Endocrine Function
- Basic Concepts of Endocrine Disorders
- Growth Hormone Disorders
- Thyroid Hormone Disorders
- Adrenocortical Hormone Disorders
- Adrenal Medulla Disorder
- Parathyroid Gland Disorders
- Antidiuretic Hormone Disorders
- Summary
- Resources
- 41 Diabetes Mellitus
- Regulation of Glucose Metabolism
- Glucose Intolerance Disorders
- Clinical Manifestations and Complications
- Treatment and Education
- Pediatric Considerations
- Geriatric Considerations
- Summary
- Resources
- 42 Nutritional and Metabolic Disorders
- Metabolic Processes
- Nutrient Metabolism
- Regulation of Appetite and Nutrient Metabolism
- Obesity and Metabolic Syndrome
- Metabolic Responses to Starvation and Physiologic Stress
- Nutritional Considerations for Aging and Altered Health States
- Summary
- Resources
- Unit XII Neural Function
- 43 Structure and Function of the Nervous System
- Structural Organization
- Neuronal Structure and Function
- Neurons and Supportive Cells
- Neuronal Communication
- Neural Development, Aging, and Injury
- Sensory Function
- Motor Function
- Consciousness, Memory, and Sleep
- Resources
- 44 Acute Disorders of Brain Function
- Traumatic Brain Injury
- Cerebrovascular Disease and Stroke
- Crebral Aneurysm and Arteriovenous Malformation
- Central Nervous System Infections
- Resources
- 45 Chronic Disorders of Neurologic Function
- Brain and Cerebellar Disorders
- Spinal Cord and Peripheral Nerve Disorders
- Summary
- Resources
- 46 Alterations in Special Sensory Function
- Hearing and Balance
- Vision
- Smell and Taste
- Resources
- 47 Pain
- Types of Pain
- Treatment Modalities
- Resources
- Unit XIII Neuropsychological Function
- 48 Neurobiology of Psychotic Illnesses
- Schizophrenia
- Major Depressive and Persistent Depressive Disorders
- Bipolar Disorder
- Population Considerations
- Summary
- Resources
- 49 Neurobiology of Nonpsychotic Illnesses
- Anxiety Disorders
- Neurodevelopmental Disorders
- Summary
- Resources
- 50 Structure and Function of the Musculoskeletal System
- Structure and Function of Bone
- Structure and Function of Joints
- Structure and Function of Articular Cartilage
- Structure and Function of Tendons and Ligaments
- Structure and Function of Skeletal Muscle
- Mechanics of Muscle Contraction
- Summary
- Resources
- Unit XIV Musculoskeletal Support and Movement
- 51 Alterations in Musculoskeletal Function
- Soft Tissue Injuries
- Bone Injuries and Infections
- Alterations in Bone Structure and Mass
- Diseases of Skeletal Muscle
- Other Disorders of Muscle
- Summary
- Resources
- 52 Alterations in Musculoskeletal Function
- Local Disorders of Joint Function
- Systemic Disorders of Joint Function
- Joint Dysfunction Secondary to Other Diseases
- Pediatric Joint Disorders
- Summary
- Resources
- Unit XV Integumentary System
- 53 Alterations in the Integumentary System
- Age-Related Changes
- Evaluation of the Integumentary System
- Selected Skin Disorders
- Infectious Processes
- Inflammatory Conditions
- Allergic Skin Responses
- Parasitic Infestations
- Other Disorders of the Dermis
- Special Characteristics of Dark Skin
- Integumentary Manifestations of Systemic Disease
- Treatment Implications
- Developmental Considerations
- Summary
- Resources
- 54 Burn Injuries
- Thermal Injury
- Electrical Injury
- Chemical Injury
- Special Populations
- Summary
- Resources
- Glossary
- A
- B
- C
- D
- E
- F
- G
- H
- I
- J
- K
- L
- M
- N
- O
- P
- R
- S
- T
- U
- V
- W
- X
- Z
- Index
- IBC
- Language: English
- Edition: 6
- Published: January 17, 2018
- Imprint: Saunders
- eBook ISBN: 9780323510424
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