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Elsevier

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

  • 1st Edition - May 30, 2019
  • Latest edition
  • Author: Naseer Ahmed
  • Language: English

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and ro… Read more

Description

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection.
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection.

Key features

  • Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance
  • Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies

Readership

Basic and Translational Researchers, Cardiovascular Scientists and Pharmacologists

Table of contents

Chapter 1: Ischemia-Reperfusion Injury

Overview of Ischemia/Reperfusion (I/R)

Events in Ischemia Reperfusion Injury

Ischemic versus reperfusion components of total tissue injury induced by I/R

Bimodal tissue Responses to I/R

I/R-induced stunning and hibernation versus irreversible cell damage and death

Organ-specific susceptibility to I/R

Remote organ injury

Therapeutic Advancement during last decade

Chapter 2: Myocardial Ischemia Circulatory Arrest

Ischemic heart diseases

Consequences of Myocardial Ischemia

Ischemia-related metabolic Alterations

Treatment option of myocardial ischemia

Pre and Post conditioning

Chapter 3 Myocardial Reperfusion

Physiology of myocardial perfusion

Extra Corporeal Circulation

Role of coronary circulation

Myocardial Stunning and hibernation

Ischemia Reperfusion Injury

Oxygen free Radicals

Inflammation and activation of complement system

Increased permeability of mPTP.

Role of mitochondrial DNA

Myocardial Cellular Death

Chapter 4: Cardioprotection

Myocardial Protection related to Ischemia-Reperfusion Injury

Oxidative Stress

Apoptosis

Post-Ischemic Mechanical Assistance (Post CA)

Pharmacological targets for known ischemia-reperfusion injury mechanisms

Chapter 5: Role of Fingolimod in Cardioprotection

Sphingosine-1-phosphate

Fingolimod

History of Fingolimod

Use of Fingolimod in clinical setting

Effects of Fingolimod

The basic mechanisms of the cardiovascular effects of Fingolimod

Recommendations for safe use of fingolimod

Mechanisms of Cardioprotection by Fingolimod

Activation of RISK and SAFE Pathways

Antioxidant action

Anti-apoptotic action

Attenuation of ischemic cardiomyopathy

Role of Sphingosine 1 phosphate -HDL in Cardioprotection

Product details

  • Edition: 1
  • Latest edition
  • Published: May 30, 2019
  • Language: English

About the author

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Naseer Ahmed

Naseer Ahmed is enthusiastic clinician-scientist who accomplished his PhD (Cardiovascular Sciences) and Postdoctoral fellowship from University of Verona, Verona, Italy. He completed his MBBS degree from Riphah International University, Islamabad, Pakistan. His research interest includes Ischemia-Reperfusion injury, Atherosclerosis & thrombosis and Arrhythmias. He is active research member of Cardiovascular Research lab, Verona and Coordinator of Functional Foods/ Complementary therapies in Cardio-metabolic disorders.
Affiliations and expertise
Assistant Professor, Department of Biological and Biomedical Science, Agha Khan University-Karachi, Karachi, Pakistan

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