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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection
- 1st Edition - May 30, 2019
- Author: Naseer Ahmed
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 8 0 2 3 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 8 2 5 3 - 6
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and ro… Read more
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Request a sales quotePathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection.
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection.
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection.
- Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance
- Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies
Basic and Translational Researchers, Cardiovascular Scientists and Pharmacologists
Chapter 1: Ischemia-Reperfusion Injury
Overview of Ischemia/Reperfusion (I/R)
Events in Ischemia Reperfusion Injury
Ischemic versus reperfusion components of total tissue injury induced by I/R
Bimodal tissue Responses to I/R
I/R-induced stunning and hibernation versus irreversible cell damage and death
Organ-specific susceptibility to I/R
Remote organ injury
Therapeutic Advancement during last decade
Chapter 2: Myocardial Ischemia Circulatory Arrest
Ischemic heart diseases
Consequences of Myocardial Ischemia
Ischemia-related metabolic Alterations
Treatment option of myocardial ischemia
Pre and Post conditioning
Chapter 3 Myocardial Reperfusion
Physiology of myocardial perfusion
Extra Corporeal Circulation
Role of coronary circulation
Myocardial Stunning and hibernation
Ischemia Reperfusion Injury
Oxygen free Radicals
Inflammation and activation of complement system
Increased permeability of mPTP.
Role of mitochondrial DNA
Myocardial Cellular Death
Chapter 4: Cardioprotection
Myocardial Protection related to Ischemia-Reperfusion Injury
Oxidative Stress
Apoptosis
Post-Ischemic Mechanical Assistance (Post CA)
Pharmacological targets for known ischemia-reperfusion injury mechanisms
Chapter 5: Role of Fingolimod in Cardioprotection
Sphingosine-1-phosphate
Fingolimod
History of Fingolimod
Use of Fingolimod in clinical setting
Effects of Fingolimod
The basic mechanisms of the cardiovascular effects of Fingolimod
Recommendations for safe use of fingolimod
Mechanisms of Cardioprotection by Fingolimod
Activation of RISK and SAFE Pathways
Antioxidant action
Anti-apoptotic action
Attenuation of ischemic cardiomyopathy
Role of Sphingosine 1 phosphate -HDL in Cardioprotection
- No. of pages: 140
- Language: English
- Edition: 1
- Published: May 30, 2019
- Imprint: Academic Press
- Paperback ISBN: 9780128180235
- eBook ISBN: 9780128182536
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Naseer Ahmed
Naseer Ahmed is enthusiastic clinician-scientist who accomplished his PhD (Cardiovascular Sciences) and Postdoctoral fellowship from University of Verona, Verona, Italy. He completed his MBBS degree from Riphah International University, Islamabad, Pakistan. His research interest includes Ischemia-Reperfusion injury, Atherosclerosis & thrombosis and Arrhythmias. He is active research member of Cardiovascular Research lab, Verona and Coordinator of Functional Foods/ Complementary therapies in Cardio-metabolic disorders.
Affiliations and expertise
Assistant Professor, Department of Biological and Biomedical Science, Agha Khan University-Karachi, Karachi, PakistanRead Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection on ScienceDirect