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Pathology and Clinical Relevance of Neoplastic Precursor Lesions of the Tubal Gut, Liver, and Pancreaticobiliary System: A Contemporary Update, An Issue of Gastroenterology Clinics of North America
- 1st Edition, Volume 53-1 - January 31, 2024
- Editor: Robert D. Odze
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 0 0 5 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 0 0 6 - 9
In this issue of Gastroenterology Clinics, guest editor Dr. Robert Odze brings his considerable expertise to the topic of Pathology and Clinical Relevance of Neoplastic Precursor… Read more
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Request a sales quoteIn this issue of Gastroenterology Clinics, guest editor Dr. Robert Odze brings his considerable expertise to the topic of Pathology and Clinical Relevance of Neoplastic Precursor Lesions of the Tubal Gut, Liver, and Pancreaticobiliary System: A Contemporary Update. Top experts review all the basic advances in the biology of neoplastic precursor lesions and its molecular and clinical implications to provide a better and more uniform understanding of mechanisms of cancer development in the gastrointestinal system and related organs.
- Contains 10 relevant, practice-oriented topics including Barrett’s esophagus and associated dysplasia; hepatic precancerous lesions and early hepatocellular carcinoma; pathology and clinical significance of inflammatory bowel disease-associated colorectal dysplastic lesions; sporadic colorectal polyps of the colon; pathology of gastrointestinal polyposis disorders; and more.
- Provides in-depth clinical reviews on neoplastic precursor lesions of the tubal gut, liver, and pancreaticobiliary system, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Gastroenterologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Foreword
- Preface
- Barrett's Esophagus and Associated Dysplasia
- Key points
- Introduction
- Clinical and endoscopic features
- Pathogenesis
- Pathology
- Adjunctive markers of dysplasia
- Risk assessment in Barrett's esophagus
- Relevance of extent of dysplasia
- Natural history of dysplasia
- Surveillance and treatment of dysplasia
- Summary
- Clinics care points
- Squamous Neoplastic Precursor Lesions of the Esophagus
- Key points
- Introduction
- Historical perspective of dysplasia/intraepithelial neoplasia
- Definition of squamous dysplasia
- Prevalence/incidence
- Risk factors
- Endoscopic characteristics
- Pathology of squamous dysplasia
- Differential diagnosis of squamous dysplasia
- Genetic alterations and pathogenesis
- Natural history
- Risk prediction and treatment
- Clinics care points
- Summary
- Clinics care points
- Pathology and Clinical Relevance of Gastric Epithelial Dysplasia
- Key points
- Introduction
- Conventional dysplastic patterns
- Nonconventional gastric dysplasias
- Management of dysplasia
- Summary
- Clinics care points
- Early Cancerous Lesions of the Pancreas and Ampulla: Current Concepts and Challenges
- Key points
- Pancreas
- Tumoral intraepithelial neoplasms
- Ampulla
- Summary
- Clinics care points
- Dysplasia and Early Carcinoma of the Gallbladder and Bile Ducts: Terminology, Classification, and Significance
- Key points
- Introduction
- Clinical features
- Pathology
- Pathologic differential diagnoses
- Ancillary diagnostic tests
- Biologic behavior and treatment
- Clinics care points
- Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma
- Key points
- Introduction
- Hepatocellular carcinoma precursor lesions in cirrhosis
- Ancillary diagnostic tests and differential diagnosis
- Precursor lesions in patients without cirrhosis
- Clinics care points
- Pathology and Clinical Significance of Inflammatory Bowel Disease-Associated Colorectal Dysplastic Lesions
- Key points
- Introduction
- Risk factors for neoplasia in inflammatory bowel disease
- Macroscopic characteristics and endoscopic classification of dysplasia
- Definition and classification of dysplasia
- Prognostic significance of dysplasia grade
- Molecular alterations in dysplasia
- Interobserver variation and ancillary markers
- Endoscopic identification of dysplasia
- Role of endoscopic surveillance and management
- New diagnostic and Therapeutic Approaches to Dysplasia
- Summary
- Clinics care points
- Sporadic Polyps of the Colorectum
- Key points
- Introduction
- Discussion
- Clinics care points
- Pathology of Gastrointestinal Polyposis Disorders
- Key points
- Introduction
- Familial adenomatous polyposis
- MUTYH-associated polyposis
- Polymerase proofreading–associated polyposis
- NTHL1 tumor syndrome
- Serrated polyposis syndrome
- Hamartomatous polyposis syndromes
- Juvenile polyposis syndrome
- Phosphatase and tensin homolog hamartoma tumor syndrome/Cowden syndrome
- Lynch syndrome
- Cronkhite-Canada syndrome
- Summary
- Anal and Perianal Preneoplastic Lesions
- Key points
- Introduction
- Anal squamous neoplasia
- Other squamous proliferations of the anal region
- Glandular preneoplastic lesions of the anus and perianal region
- Anal and perianal Paget disease
- Melanocytic preneoplastic lesions of the anal region
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 53-1
- Published: January 31, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443130052
- eBook ISBN: 9780443130069
RO
Robert D. Odze
Affiliations and expertise
Professor of Pathology, Harvard Medical School; Chief, GI Pathology Service, Brigham and Women's Hospital, Boston, MA