Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America

1st Edition, Volume 36-5 - October 20, 2022
Editors: Matthew B. Yurgelun, Douglas A. Rubinson
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 5 5 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 5 6 - 4

In this issue of Hematology/Oncology Clinics, guest editors Drs. Matthew B. Yurgelun and Douglas A. Rubinson bring their considerable expertise to the topic of Pancreatic Cancer.… Read more

Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America

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In this issue of Hematology/Oncology Clinics, guest editors Drs. Matthew B. Yurgelun and Douglas A. Rubinson bring their considerable expertise to the topic of Pancreatic Cancer. Top experts in the field cover key topics such as pancreatic adenocarcinoma: trends in epidemiology, risk factors, and outcomes; decision making regarding perioperative therapy in individuals with localized pancreatic adenocarcinoma; the evolving role of radiotherapy in the management of individuals with pancreatic adenocarcinoma; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Pancreatic Adenocarcinoma: Trends in Epidemiology, Risk Factors, and Outcomes
Key points
Introduction
Summary
Clinics care points
The Interplay Among Pancreatic Cancer, Cachexia, Body Composition, and Diabetes
Key points
Introduction
Pathophysiology and preclinical pancreatic ductal adenocarcinoma cachexia models
Cachexia, muscle wasting and adiposity-related clinical outcomes in pancreatic ductal adenocarcinoma
Assessment and management considerations for pancreatic ductal adenocarcinoma cachexia
Summary
Clinics care points
What Can We Learn About Pancreatic Adenocarcinoma from Imaging?
Key points
Introduction
Imaging
Guidelines
Approach
Summary
Clinics care points
Screening and Surveillance for Pancreatic Adenocarcinoma in High-Risk Individuals
Key points
Introduction
Assessment of pancreatic ductal adenocarcinoma risk
Candidates for pancreatic ductal adenocarcinoma surveillance
Targets and goals of surveillance
Current approaches to pancreatic cancer surveillance
Additional recommendations for high-risk individuals
Potential harms
Future directions
Summary
Clinics care points
Germline Testing for Individuals with Pancreatic Adenocarcinoma and Novel Genetic Risk Factors
Key points
Current guidelines for germline genetic testing of pancreatic ductal adenocarcinoma susceptibility genes
Decision-Making Regarding Perioperative Therapy in Individuals with Localized Pancreatic Adenocarcinoma
Key points
Introduction
History of adjuvant care
Role of surgical resection
Localized pancreatic adenocarcinoma
Perioperative management
Summary
Clinics care points
Author contributions
Funding
Disclosure
Novel Considerations in Surgical Management of Individuals with Pancreatic Adenocarcinoma
Key points
Introduction
Clinical presentation and diagnostic workup
Management of operable pancreatic cancer
Expanding surgical selection
Summary
Clinics care points
Radiotherapy for Pancreatic Adenocarcinoma: Recent Developments and Advances on the Horizon
Key points
Introduction
Summary
Clinics care points
Cytotoxic Chemotherapy in Advanced Pancreatic Cancer
Key points
Introduction
First-line therapy
Second-line therapy
Summary
Clinics care points
PARPis and Other Novel, Targeted Therapeutics in Pancreatic Adenocarcinoma
Key points
Introduction
Poly-ADP ribose polymerase inhibitors
Predictive biomarkers of poly-ADP ribose polymerase inhibitor in pancreatic ductal adenocarcinoma
Future directions for poly-ADP ribose polymerase inhibitor in pancreatic ductal adenocarcinoma
NTRK fusions
Neuregulin 1 fusions
Mismatch repair deficiency in pancreatic ductal adenocarcinoma
KRAS G12C mutations
Summary
Clinics care points
Genetics of Pancreatic Neuroendocrine Tumors
Key points
Introduction
Somatic mutations in patients with pancreatic neuroendocrine tumors
Genes related to the mammalian target of rapamycin
Potential clinical utility of somatic testing in patients with neuroendocrine tumors
Germline mutations in patients with pancreas neuroendocrine tumors
Others
Potential clinical utility of germline testing in patients with neuroendocrine tumors
Summary
Clinics care points
Palliative and Supportive Care for Individuals with Pancreatic Adenocarcinoma
Key points
Palliative and supportive care needs for individuals with pancreatic adenocarcinoma
Palliative and supportive care services in oncology
Benefits of palliative and supportive care interventions in oncology
Data regarding palliative and supportive care in pancreatic adenocarcinoma
Future directions for palliative and supportive care in pancreatic adenocarcinoma
Clinics care points

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Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America

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Matthew B. Yurgelun

Douglas A. Rubinson