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Elsevier

Paclitaxel

Sources, Chemistry, Anticancer Actions, and Current Biotechnology

  • 1st Edition - October 8, 2021
  • Latest edition
  • Editors: Mallappa Kumara Swamy, T. Pullaiah, Zhe-Sheng Chen
  • Language: English

Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and antic… Read more

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Description

Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer.

This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments.

Key features

  • Presents detailed information about Paclitaxel research, from its discovery to clinical uses and biotechnological routes of commercial production
  • Focuses on Paclitaxel development as an effective chemotherapeutic drug, along with its application in different types of cancers
  • Encompasses descriptive illustrations and workflows to help the reader fully understand the content and easily apply it to their research

Readership

Graduate students and researchers on cancer and biotechnology

Table of contents

1. About Cancers and treatment options: An update 2. Paclitaxel: Chemistry, synthetic analogues and their anticancer properties 3. Paclitaxel: Mechanisms of action against cancer, an update with current research 4. Novel forms of Paclitaxel for an effective cancer cure 5. Clinical pharmacology of Paclitaxel 6. Strategies for enhancing bioavailability of Paclitaxel for cancer treatment 7. Application of nanocarriers for Paclitaxel delivery and chemotherapy of cancer 8. Paclitaxel: Cancer chemotherapy evidences, advantages, and future directions 9. Anticancer drug Paclitaxel producing plants. Their taxonomy, morphology, identification, distribution and other botanical details 10. Propagation and micropropagation of Paclitaxel producing plants 11. Biotechnology of Paclitaxel producing plants (Paclitaxel production through hairy root cultures, suspension cultures, callus cultures etc.) 12. Endophytes for the production of anticancer drug Paclitaxel 13. Metabolic engineering strategies to enhance the production of anticancer drug Paclitaxel 14. Paclitaxel and chemoresistance 15. Overcoming Paclitaxel resistance 16. Paclitaxel and lung cancer treatment 17. An update on Paclitaxel treatment in breast cancer: Pros and cons

Product details

  • Edition: 1
  • Latest edition
  • Published: October 11, 2021
  • Language: English

About the editors

MS

Mallappa Kumara Swamy

Mallappa Kumara Swamy, PhD, completed his Postdoctoral Research at the Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia (UPM), from 2014-2018. He has more than 16 years of teaching and research experience in the fields of plant biotechnology, secondary metabolites production, phytochemistry and bioactive studies. Dr. Swamy has published more than 100 research publications in peer- reviewed journals, 25 book chapters and has edited 10 books with reputed international publishers. His research focuses on the area of natural products, plant cell, tissue culture technology for bioactive compounds production and evaluation of their bioactivities, and nanobiotechnology for medical applications.
Affiliations and expertise
Professor, Department of Biotechnology at East West First Grade College (Affiliated to Bangalore University), India

TP

T. Pullaiah

T. Pullaiah earned his PhD from Andhra University and then pursued a postdoctoral fellowship at Moscow State University (1976–1978). He is a former Professor of Botany at Sri Krishnadevaraya University, where he taught for more than 35 years. He served as president of the Indian Botanical Society in 2014 and of the Indian Association for Angiosperm Taxonomy in 2013. His honors include the Panchanan Maheshwari Gold Medal, the Prof. P. C. Trivedi Medal, the Dr. G. Panigrahi Memorial Lecture Award of the Indian Botanical Society, and the Prof. Y. D. Tyagi Gold Medal of IAAT. A prolific author and editor, Prof. Pullaiah has mentored students throughout his career and, for several years, has also been a member of the IUCN Species Survival Commission, a global network of over 10,000 volunteer experts dedicated to conserving biodiversity and preventing species extinction through science-based action and collaboration.

Affiliations and expertise
(Retired) Professor, Department of Botany, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India

ZC

Zhe-Sheng Chen

Zhe-Sheng Chen, PhD, opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen has over 170 papers published, co-edited Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy book (Elsevier), and holds 5 patents.
Affiliations and expertise
Editor of "African Journal of Pharmacy and Pharmacology"; Editor-in-Chief “Journal of Cancer Research Updates" and "Journal of New Developments in Chemistry"

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