
Paclitaxel
Sources, Chemistry, Anticancer Actions, and Current Biotechnology
- 1st Edition - October 8, 2021
- Imprint: Academic Press
- Editors: Mallappa Kumara Swamy, T. Pullaiah, Zhe-Sheng Chen
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 9 5 1 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 9 5 2 - 5
Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and antic… Read more

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Request a sales quotePaclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer.
This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments.
- Presents detailed information about Paclitaxel research, from its discovery to clinical uses and biotechnological routes of commercial production
- Focuses on Paclitaxel development as an effective chemotherapeutic drug, along with its application in different types of cancers
- Encompasses descriptive illustrations and workflows to help the reader fully understand the content and easily apply it to their research
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- 1: Introduction to cancer and treatment approaches
- Abstract
- 1.1: Introduction
- 1.2: About cancer biology: Causes and risk factors
- 1.3: Cancer types, classification, and grading
- 1.4: Therapeutic interventions for cancer
- 1.5: Advanced approaches for cancer treatment
- 1.6: Conclusions
- 2: Taxol: Occurrence, chemistry, and understanding its molecular mechanisms
- Abstract
- 2.1: Introduction
- 2.2: About taxol and its discovery
- 2.3: Natural resources of taxol
- 2.4: Chemistry of taxol
- 2.5: Mechanisms of action of taxol
- 2.6: Conclusion and future prospects
- 3: Taxol: Mechanisms of action against cancer, an update with current research
- Abstract
- Acknowledgment
- 3.1: The discovery and evolution of Paclitaxel (Taxol)
- 3.2: Paclitaxel (Taxol) induces mitotic cell cycle arrest
- 3.3: Taxol induces gene-directed apoptosis
- 3.4: Taxol and calcium-dependent apoptosis
- 3.5: Immunomodulation effects by Taxol
- 3.6: Resistance mechanisms of Taxol
- 3.7: Conclusion
- 4: Application of nanocarriers for paclitaxel delivery and chemotherapy of cancer
- Abstract
- 4.1: Introduction
- 4.2: Nanoparticles
- 4.3: Liposomes
- 4.4: Dendrimers
- 4.5: Micelles
- 4.6: Nanotubes
- 4.7: Niosomes
- 4.8: Proniosomes
- 4.9: Ethosomes
- 4.10: Microparticles
- 4.11: Carbon dots
- 4.12: Clinical trials
- 4.13: Overcoming paclitaxel resistance by using Nanocarriers
- 4.14: Selected patents for paclitaxel formulations
- 4.15: Conclusion
- 5: Strategies for enhancing paclitaxel bioavailability for cancer treatment
- Abstract
- 5.1: Introduction
- 5.2: Alternative paclitaxel sources
- 5.3: Strategies of paclitaxel biosynthesis improvement in plant cell culture
- 5.4: Mathematical modeling for paclitaxel biosynthesis optimization
- 5.5: Concluding remarks and future perspectives
- 6: Botany of paclitaxel producing plants
- Abstract
- 6.1: History of taxol
- 6.2: Botany of Taxus
- 6.3: Enumeration of taxol producing plant species
- 6.4: Taxol from angiosperms
- 6.5: Conclusions and future direction
- 7: Propagation of paclitaxel biosynthesizing plants
- Abstract
- 7.1: Introduction
- 7.2: Propagation
- 7.3: Micropropagation
- 7.4: Conclusions
- 8: Endophytes for the production of anticancer drug, paclitaxel
- Abstract
- 8.1: Introduction
- 8.2: Paclitaxel sources in nature
- 8.3: Available approaches for paclitaxel production
- 8.4: Endophytes producing paclitaxel from different host plant species
- 8.5: Anticancer properties of endophytes-derived paclitaxel
- 8.6: Conclusions
- 9: Metabolic engineering strategies to enhance the production of anticancer drug, paclitaxel
- Abstract
- 9.1: Introduction
- 9.2: Historical perspective of paclitaxel
- 9.3: Metabolic engineering strategies for paclitaxel production
- 9.4: Conclusions
- 10: Paclitaxel and chemoresistance
- Abstract
- 10.1: Introduction
- 10.2: Mechanisms of chemoresistance
- 10.3: Clinical markers of paclitaxel resistance
- 10.4: Strategies to overcome paclitaxel resistance
- 10.5: Summary
- 11: Paclitaxel and cancer treatment: Non-mitotic mechanisms of paclitaxel action in cancer therapy
- Abstract
- 11.1: Introduction
- 11.2: Microtubule stabilization and anti-mitotic mechanisms
- 11.3: Mitotic catastrophe
- 11.4: Non-mitotic mechanisms
- 11.5: Importance of micronucleation
- 11.6: Innate immunity leading to the bystander effect
- 11.7: Cellular retention of paclitaxel
- 11.8: Combination therapy
- 11.9: Prospective: New formulation of paclitaxel and additional microtubule stabilizing drugs
- 11.10: Conclusions
- 12: An update on paclitaxel treatment in breast cancer
- Abstract
- Acknowledgment
- 12.1: Introduction
- 12.2: Types of breast cancer
- 12.3: Molecular mechanism of paclitaxel in breast cancer
- 12.4: Paclitaxel treatment in different types of breast cancer
- 12.5: Adverse events and resistance due to paclitaxel treatment
- 12.6: Efficiency of other anti-cancer drugs over paclitaxel
- 12.7: Conclusions
- 13: Paclitaxel conjugated magnetic carbon nanotubes induce apoptosis in breast cancer cells and breast cancer stem cells in vitro
- Abstract
- Acknowledgments
- Conflict of interest statement
- 13.1: Introduction
- 13.2: Experimental details
- 13.3: Results and discussion
- 13.4: Conclusions
- Index
- Edition: 1
- Published: October 8, 2021
- Imprint: Academic Press
- No. of pages: 354
- Language: English
- Paperback ISBN: 9780323909518
- eBook ISBN: 9780323909525
MS
Mallappa Kumara Swamy
TP
T. Pullaiah
ZC