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Osteoarthritis, An Issue of Clinics in Geriatric Medicine
- 1st Edition, Volume 38-2 - April 14, 2022
- Editor: David Hunter
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 8 7 0 7 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 7 0 8 - 0
In this issue of Clinics in Geriatric Medicine, guest editor Dr. David Hunter brings his considerable expertise to the topic of Osteoarthritis. Top experts in… Read more
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Request a sales quoteIn this issue of Clinics in Geriatric Medicine, guest editor Dr. David Hunter brings his considerable expertise to the topic of Osteoarthritis. Top experts in the field cover key topics such as obesity and nutrition influences in osteoarthritis, the genesis of pain in osteoarthritis, overview of disease management, and more.
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Contains 14 relevant, practice-oriented topics including overview of disease management, concordance with guidelines, and strategies to increase implementation of best evidence; obesity and nutrition influences in osteoarthritis; pathogenesis of osteoarthritis; behavior change barriers and facilitators in people with osteoarthritis; suitable candidates and realistic expectations in surgery for osteoarthritis; and more.
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Provides in-depth clinical reviews on osteoarthritis, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Burden of Osteoarthritis in Older Adults
- Key points
- Introduction
- Incidence and prevalence of symptomatic OA
- Risk factors for OA
- The relationship between social determinants of health and OA
- Impact of OA on other conditions and mortality
- Living with OA
- Contextual factors influencing the downstream impact of painful OA
- Economic impact of OA
- Summary
- Clinics care points
- Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach
- Key points
- Introduction
- Targeting cartilage degradation to treat osteoarthritis: Linda Troeberg
- Targeting inflammation to treat osteoarthritis: Christopher B. Little
- Targeting synovial fibrosis to treat osteoarthritis: Mohit Kapoor
- Targeting regeneration of cartilage to treat osteoarthritis: Tonia L. Vincent
- Targeting bone remodeling to treat osteoarthritis: Tamara Alliston
- Targeting aging and cell senescence to treat osteoarthritis: Richard F. Loeser
- Summary
- Clinics care points
- Funding
- Author contributions
- Competing interests
- Data and materials availability
- Patient and Public involvement
- Disclosure
- The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain
- Key points
- Osteoarthritis pain: a worldwide unmet medical need
- Pain in osteoarthritis
- Local inflammation in the osteoarthritis joint: contributions to pain
- Neuroinflammation: an emerging player in osteoarthritis pain
- Systemic inflammatory inputs to pain
- Conclusions and future directions
- Author contributions
- Osteoarthritis Flares
- Key points
- Introduction
- Recognizing and defining OA flares
- Triggers for OA flares
- OA flare patterns and symptom variability
- Acute flare management and long-term OA management
- Summary
- Clinics care points
- Disclosure
- The Challenges in the Primary Prevention of Osteoarthritis
- Key points
- Introduction
- Identifying the target group
- Designing the intervention
- Measuring the effect
- Conclusions and recommendations
- Clinics care points
- Phenotypes in Osteoarthritis: Why Do We Need Them and Where Are We At?
- Key points
- Introduction
- What are OA phenotypes?
- Historical background—how has OA phenotyping research started?
- Approaches for OA phenotyping
- Current status of OA phenotyping—where are we at?
- Use of big data and machine learning for OA phenotyping
- Future directions
- Clinics care points
- Disclosure
- Best Evidence Osteoarthritis Care: What Are the Recommendations and What Is Needed to Improve Practice?
- Key points
- Introduction and background
- Summary of key osteoarthritis clinical practice guidelines and recommendations
- Strategies to support moving from clinical guidelines to clinical care
- Models and programs to improve the delivery of OA care
- OA programs implemented in the real world
- Evaluating the quality of OA care
- Summary
- Clinics care points
- Disclosure
- The Role of Nutrition in Osteoarthritis: A Literature Review
- Key points
- Introduction
- Discussion
- Clinics care points
- Towards a Communication Framework for Empowerment in Osteoarthritis Care
- Key points
- Background
- Aims and methods
- What is empowerment?
- Models of empowerment in health
- Principles of empowerment
- Proposed Framework for Empowerment in Osteoarthritis Practice
- Challenges to empowerment education and directions for future research
- Summary
- Clinics care points
- Predictors and Measures of Adherence to Core Treatments for Osteoarthritis
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Disclosure
- A Framework to Guide the Development of Health Care Professional Education and Training in Best Evidence Osteoarthritis Care
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Surgery for Osteoarthritis: Total Joint Arthroplasty, Realistic Expectations of Rehabilitation and Surgical Outcomes: A Narrative Review
- Key points
- Introduction
- TJA: what, why, who, and when
- Realistic expectations: rehabilitation after TJA
- Rehabilitation after THA and TKA: current clinical practice
- Realistic expectations: outcomes of the surgery
- Summary
- Clinics care points
- Prospects of Disease-Modifying Osteoarthritis Drugs
- Key points
- Introduction
- Osteoarthritis subtypes: phenotypes and endotypes
- Synovitis-driven endotype
- Interleukin-1 inhibitors
- Anti-interleukin-6 inhibitors
- Interleukin-10 agonists
- Methotrexate
- Bone-driven endotype
- Cathepsin K inhibitor
- Parathyroid hormone
- Matrix extracellular phosphoglycoprotein
- Antiresorptive drugs: bisphosphonates and denosumab
- Vitamin D
- Cartilage-driven endotype
- Proteinase inhibitors
- Fibroblast growth factor-18
- Transforming growth factor-β
- Wnt signaling inhibitors
- Senolytic therapies
- Perspectives
- Summary
- Realizing Health and Well-being Outcomes for People with Osteoarthritis Beyond Health Service Delivery
- Key points
- Introduction and background
- Discussion
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 38-2
- Published: April 14, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323987073
- eBook ISBN: 9780323987080
DH
David Hunter
Affiliations and expertise
Florance and Cope Chair of Rheumatology ,Chair of Institute of Bone and Joint Research , Professor of Medicine, University of Sydney