OrthoBiologics
- 1st Edition - August 15, 2024
- Imprint: Academic Press
- Editors: Rachel M. Frank, Jorge Chahla, Garrett Jackson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 9 0 2 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 9 0 3 - 3
OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a s… Read more
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Request a sales quoteOrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.
In addition to covering current approaches and applications, the editors aim for this book to present “best practices” for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market.
- Presents the current state-of-the-art treatments for orthobiologics, including PRP, stem cell therapy, growth factors, scaffolds, and more
- Includes a comprehensive overview of orthobiologics, including definitions, terminology, processing characteristics, clinical outcomes, and more
- Presents current information on the ever-changing regulatory environment
- Provides real-time information on clinical and surgical utilization of orthobiologics
- Written for clinicians, researchers, and students, with content relevant to all those who participate in orthobiologic research and treatment, including orthopaedic surgeons, sports medicine specialists, rheumatologists, physiatrists, and any/all clinicians and researchers with an interest in orthobiologics and regenerative medicine.
All relevant technical staff in biotherapy companies, Academic, researchers, PhD students, and orthopedic specialists, especially for joint reconstruction surgeons, physicians, nurses, academics and researchers of regenerative medicine, naturalists, and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Chapter 1. Autologous blood: platelet-rich plasma and platelet-poor plasma
- Abstract
- Outline
- Introduction
- Composition
- Platelet-rich fibrin
- Fibrin functions in regeneration
- Applications in orthopedics
- Meniscus healing
- Tendon healing
- Platelet-rich plasma in muscle healing
- Platelet-rich plasma in cartilage
- Conclusion
- References
- Chapter 2. Defining, measuring and optimizing platelet-rich plasma
- Abstract
- Outline
- Defining platelet-rich plasma
- Commercial system platelet-rich plasma variability
- Proposed platelet-rich plasma classifications
- Quantifying platelet-rich plasma
- Benchside analysis point of care
- Future directions
- References
- Chapter 3. Optimal use of platelet-rich plasma and platelet-poor plasma
- Abstract
- Outline
- Introduction
- Platelet-rich plasma and platelet-poor plasma: overview
- Muscle healing
- Common clinical applications
- Rotator cuff disease
- Ulnar collateral ligament injuries
- Hip osteoarthritis
- Knee osteoarthritis
- Achilles tendinopathy
- Summary
- References
- Chapter 4. Where orthobiologics started: what are mesenchymal stem cells?
- Abstract
- Outline
- Introduction
- Orthobiologics: a historical overview
- What are mesenchymal stem cells?
- What mesenchymal stem cells are not
- Orthopedic applications of mesenchymal stem cells
- Conclusion
- References
- Chapter 5. Bone marrow-derived mesenchymal stromal cells
- Abstract
- Outline
- Introduction
- Harvest and preparation
- Senescence
- Regulations
- Bone marrow-derived mesenchymal stromal cells versus concentrated bone marrow aspirate
- Uses
- Challenges for clinical application
- Conclusion
- Social media
- References
- Chapter 6. Defining, optimizing, and measuring bone marrow aspirate and bone marrow concentrate
- Abstract
- Outline
- Introduction
- Bone marrow extraction method
- Overview of bone marrow harvesting guidance techniques
- Differences between bone marrow aspirate and bone marrow concentrate
- Literature summary of results Bone marrow application in osteoarthritis
- Conclusion
- References
- Chapter 7. Optimal clinical use of bone marrow aspirate and bone marrow aspirate concentrate
- Abstract
- Outline
- Introduction
- Patient selection
- Clinical uses/outcomes
- Potential complications
- Conclusion
- References
- Further reading
- Chapter 8. Adipose tissue-derived stromal/stem cells
- Abstract
- Outline
- Introduction
- Chondroinduction by adipose tissue-derived stromal/stem cells
- Immunomodulation by adipose tissue-derived stromal/stem cells
- Conclusion
- References
- Chapter 9. Defining, optimizing, measuring, and utilizing adipose, MFAT, etc.
- Abstract
- Outline
- Introduction
- Adipose as a source of stem cells
- Mechanism of adipose function
- Preparation of adipose stem cells
- Clinical application
- Limitations and shortcomings
- Next steps and future directions
- Conclusions
- References
- Chapter 10. Optimal clinical use of adipose mesenchymal stromal cells
- Abstract
- Outline
- Introduction
- Biology of adipose-derived mesenchymal stromal cells
- Clinical use of adipose-derived mesenchymal stromal cells
- Practical considerations
- Limitations and future directions
- Conclusion
- Disclosure statement
- References
- Chapter 11. Basic science and preclinical evidence for amniotic membrane−derived allografts in orthobiologics
- Abstract
- Outline
- Introduction
- Sources and isolation of placental-derived orthobiologics
- Preclinical studies using amniotic membrane-derived products
- Challenges and limitations of using amniotic membrane-derived orthobiologics
- Conclusion
- References
- Chapter 12. Defining, optimizing, and measuring amniotic/placental mesenchymal stem cells
- Abstract
- Outline
- Anatomy and function
- Formulation
- Effects of use
- Conclusion
- References
- Chapter 13. Optimal clinical use of amniotic/placental mesenchymal stem cells
- Abstract
- Outline
- Introduction
- History and basic science of birth tissue products
- Advantages and disadvantages of using amniotic/placental mesenchymal stem cells
- Current evidence of successful clinical use of amniotic/placental mesenchymal stem cells
- Future directions and challenges for the clinical use of amniotic/placental-derived allografts
- Conclusion
- References
- Chapter 14. Synovial mesenchymal stem cells
- Abstract
- Outline
- Introduction
- Background
- The synovium
- Role of mesenchymal stem cells in cartilage regeneration
- Synovial mesenchymal stem cells
- Conclusion
- Future directions
- Disclosures
- References
- Chapter 15. Peripheral blood stem cells
- Abstract
- Outline
- Introduction
- Developmental perspective hematology oncology
- Developmental background for cartilage repair
- Food Drug Administration pathway
- Expanding indications for peripheral blood stem cells
- Conclusions
- References
- Chapter 16. Orthobiologics—growth factors and mediators
- Abstract
- Outline
- Introduction
- Growth factors
- Future perspectives
- Conclusion
- References
- Chapter 17. Orthobiologics in the procedure room—who, what, where, when, and how
- Abstract
- Outline
- Introduction
- Platelet-rich plasma
- Bone marrow aspirate concentrate
- Adipose
- Amnion
- Conclusion
- References
- Chapter 18. Orthobiologics in the operating room—who, what, where, when, and how
- Abstract
- Outline
- Introduction
- Surgical techniques
- Specific indications in the orthopedic operating room
- Conclusion
- References
- Chapter 19. The changing regulatory environment: regulations and restrictions
- Abstract
- Outline
- Introduction
- Tissue regulations
- Beyond tissue products: minimal manipulation, homologous use, and carrier impact
- Practice of medicine
- Return to product regulation
- References
- Further reading
- Chapter 20. Bioscaffolds for osteochondral injuries of the knee
- Abstract
- Outline
- Articular cartilage repair with bioscaffolds
- Agili-C™ (Cartiheal Ltd., Israel)
- Surgical technique and rehabilitation protocol
- MaioRegen® (Fin-Ceramica S.p.A., Faenza, Italy)
- Autologous matrix-induced chondrogenesis Chondro-Gide (Geistlich)
- Current literature available for synthetic grafts
- Conclusions
- References
- Chapter 21. Orthobiologics on the horizon
- Abstract
- Outline
- Introduction
- Biological pathways as therapeutic targets
- Advancement of existing approaches
- Emerging therapeutic strategies
- Conclusion
- References
- Chapter 22. Complications associated with orthobiologics
- Abstract
- Outline
- Introduction
- Complications associated with cell therapies
- Incidence of complications
- Management of complications
- Prevention
- Conclusion
- References
- Further reading
- Index
- Edition: 1
- Published: August 15, 2024
- No. of pages (Paperback): 280
- No. of pages (eBook): 300
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128229026
- eBook ISBN: 9780128229033
RF
Rachel M. Frank
Dr. Rachel M. Frank is a board-certified Orthopedic Surgeon and Sports Medicine Specialist, focusing on the surgical and nonsurgical management of knee, shoulder, and elbow injuries. She has specialized training and technical expertise in advanced knee and shoulder arthroscopy, joint preservation surgery, cartilage/meniscus restoration surgery, shoulder instability surgery, care of the female athlete, and orthobiologics. She is an Associate Professor of Orthopedic Surgery at the University of Colorado School of Medicine and is the Director of the Joint Preservation Program at the same university. Dr. Frank serves as the Editor-In-Chief for the Journal of Cartilage and Joint Preservation (JCJP), has authored over 300 peer-reviewed journal articles, over 70 book chapters, and 5 edited books. She presents her research both nationally and internationally at orthopedic conferences and meetings every year. She is head Team Orthopaedic Surgeon for the Colorado Rapids professional soccer team, and a network Team Physician for U.S. Soccer.
Affiliations and expertise
Associate Professor in Orthopaedic Surgery, University of Colorado School of Medicine, USA; Director, Joint Preservation Program, Department of Orthopaedic Surgery, University of Colorado School of Medicine, USA; Associate Fellowship Director, Sports Medicine, Department of Orthopaedic Surgery, University of Colorado School of Medicine, USAJC
Jorge Chahla
Dr. Jorge Chahla is an Orthopedic Surgeon who specializes in the treatment of complex knee, hip, and other sports-related injuries. He is an Associate Professor in the Department of Orthopedic Surgery at Rush University Medical Center and serves as the Director of Biomechanical Research and of the International Fellowship Program. He is a Team Physician for the Chicago White Sox (MLB), the Chicago Bulls (NBA), and the Chicago Fire (MLS). Dr. Chahla completed several fellowships at the top programs in the United States. He is internationally recognized for his contributions to the field of sports medicine injuries through minimally invasive techniques as well as for being a pioneer in novel biological treatments. Dr. Chahla has a strong focus on joint preservation procedures and cartilage restoration techniques with more than 500 publications in prestigious scientific journals, over 50 book chapters, 8 edited books, and he presents his research both nationally and internationally at orthopedic conferences and meetings every year.
Affiliations and expertise
Assistant Professor of Orthopedic Surgery and Director of Biomechanical Research and of the International Fellowship Program, Rush University Medical Center, USAGJ
Garrett Jackson
Dr. Garrett R. Jackson is an Orthopedic Surgery Resident at the University of Missouri School of Medicine. Before residency, he served as a Research Fellow at Rush University Medical Center with a focus on sports medicine injuries, joint preservation, and meniscus/cartilage restoration. Dr. Jackson has authored over 100 peer-reviewed journal articles in prestigious scientific journals and contributed to numerous book chapters. He has presented his research at both international and national orthopedic conferences, demonstrating his commitment to advancing orthopedic research and practice.
Affiliations and expertise
Orthopaedic Surgery Clinical Research Fellow, Midwest Orthopaedics, Rush University Medical Center, Chicago, IL, USARead OrthoBiologics on ScienceDirect