Orthobiologics, An Issue of Physical Medicine and Rehabilitation Clinics of North America

1st Edition, Volume 34-1 - November 22, 2022
Editors: Michael Khadavi, Luga Podesta
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 9 8 9 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 9 9 0 - 6

In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Michael Khadavi and Luga Podesta bring their considerable expertise to the topic of… Read more

Orthobiologics, An Issue of Physical Medicine and Rehabilitation Clinics of North America

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In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Michael Khadavi and Luga Podesta bring their considerable expertise to the topic of Orthobiologics. Use and research surrounding naturally derived substances that are used to help heal and repair orthopedic injuries are expanding rapidly. In this issue, top experts discuss the most up-to-date uses of orthobiologics in the rehabilitation setting.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Basic Science of Autologous Orthobiologics: Part 1. Platelet-Rich Plasma
Key points
Introduction
Substantial inconsistencies in platelet-rich plasma products
Confusing platelet-rich plasma terminology
Clinical-platelet-rich plasma delineated
Platelet-rich plasma fundamentals for tissue repair and regeneration
The biology of tissue repair using autologous biologics
Platelets and analgesic effects
A role for platelet serotonin
Clinics care points
Basic Science of Autologous Orthobiologics: Part 2. Mesenchymal Stem Cells
Key points
Introduction
What are stem cells?
Part 2. Bone marrow concentrate
Part 3. Adipose tissue concentrate
Clinics care points
Basic Science of Allograft Orthobiologics
Key points
Introduction
Summary
Disclosure
Clinics care points
Medical Concerns in Orthobiologics Procedures
Key points
Introduction
Summary
Disclosure
Evidence-Based Approach to Orthobiologics for Osteoarthritis and Other Joint Disorders
Key points
Introduction
Summary
Clinics care points
An Evidence-Based Approach to Orthobiologics for Tendon Disorders
Key points
Introduction
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Platelet-rich plasma
Mesenchymal signaling cells
Summary
Disclosure
Protocols and Techniques for Orthobiologic Procedures
Key points
Introduction
Pre-procedural considerations
General procedural techniques
Procedural anesthesia
Post-procedural pain management
Aspiration techniques
Joint techniques
Tendon and ligament techniques
Spine techniques
Intra-osseous technique
Summary
Clinics care points
Disclosure
Intradiscal Leukocyte Rich Platelet Rich Plasma for Degenerative Disc Disease
Key points
Introduction
Clionics care points
Disclosure
Orthobiologic Treatment of Ligament Injuries
Introduction
Ligament healing
Inflammatory phase
Proliferative phase
Remodeling phase
Intra-articular and extra-articular ligaments
Combined therapies
Knee
Summary
Prolotherapy: A Narrative Review of Mechanisms, Techniques, and Protocols, and Evidence for Common Musculoskeletal Conditions
Key points
Introduction
Mechanism of action
Techniques and protocol
Evidence for common and uncommon musculoskeletal conditions
Summary
Clinics care points
Orthobiologic Interventions for Muscle Injuries
Key points
Introduction
Discussion
Additional clinical considerations
Guidelines from professional sport organizations
Summary
Clinics care points
Special Populations in Orthobiologics: Athletic, Elderly, and Pediatrics Populations
Key points
Introduction/History/Definitions/Background
Discussion
Discussion
Future Directions: Suggested Areas of Focus
Summary
Clinics care points
Disclosure
Acknowledgment
Clinical Rationale and Rehabilitation Guidelines for Post Biologic Therapy
Introduction
Orthobiologic formulations
Tissue healing
Therapy guidelines for rehabilitation
Summary
Orthobiologic Techniques for Surgical Augmentation
Key points
Introduction
Principles of tissue healing and rationale for augmentation
Cell-based augmentation
Factor-based augmentation
Biomechanical augmentation
Summary
Clinics care points
Regulatory Considerations of Orthobiologic Procedures
Key points
Introduction
Discussion
Summary
Clinics care points
Orthobiologic Standardization and Clinical Outcome Measurement
Key points
Introduction
History
Background: need for standardization
Discussion
Summary
Clinics care points
Regional Anesthesia for Orthobiologic Procedures
Key points
Introduction
Common nerve block techniques
Clinics care points
Summary and final recommendations

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Orthobiologics, An Issue of Physical Medicine and Rehabilitation Clinics of North America

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Michael Khadavi

Luga Podesta