One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A

1st Edition, Volume 367 - April 20, 2022
Imprint: Academic Press
Editors: Samanta Antonella Mariani, Luca Cassetta
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 4 1 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 4 2 - 2

One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A, provides in-depth reviews on the last progresses on the role of macrophag… Read more

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One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A, provides in-depth reviews on the last progresses on the role of macrophages in health and diseases with a special focus on the role of macrophages in SARS-COV2, breast cancer, liver and salivary glands.

Cover
Title page
Table of Contents
Copyright
Contributors
Chapter One: Pulmonary macrophages and SARS-Cov2 infection
Abstract
1: Introduction
2: Macrophages in the healthy lung
3: Inflammation as a driver of COVID-19 severity
4: Macrophage as mediators of organ damage in COVID-19?
5: Targeting the macrophage in severe COVID-19: Current and future therapeutics?
Acknowledgments
References
Chapter Two: Macrophage control of Crohn's disease
Abstract
1: Introduction
2: Development of intestinal macrophages
3: Localization and heterogeneity of intestinal macrophages
4: Functional properties of intestinal macrophages
5: Maintenance of homeostatic macrophage function
6: Macrophages in Crohn's disease
7: Macrophages contribute to in intestinal inflammation in CD
8: Macrophage functions and dysfunctions in Crohn's disease
9: Targeting macrophages to improve Crohn's disease
Acknowledgments
References
Chapter Three: Metabolism in tumor-associated macrophages
Abstract
1: Introduction
2: Glucose metabolism
3: Amino acid metabolism
4: Lipid metabolism in TAM
5: Targeting TAM metabolism for therapy
6: Conclusion
References
Chapter Four: Macrophages in the kidney in health, injury and repair
Abstract
1: Introduction
2: Identification of renal macrophages
3: Ontology of renal macrophage and their role in the developing kidney
4: Macrophage phenotypic heterogeneity
5: Role of macrophages in renal immunosurveillance
6: Macrophages in renal injury
7: Macrophages in renal repair
8: Therapeutic prospects
9: Conclusions
References
Chapter Five: Heterogeneity and function of macrophages in the breast during homeostasis and cancer
Abstract
1: Introduction
2: Mammary gland macrophages
3: Breast cancer
4: Macrophages in breast cancer
5: Concluding remarks and future perspectives
References
Chapter Six: Endometrial macrophages in health and disease
Abstract
1: Introduction
2: Endometrial physiology
3: Endometrial macrophages—Origin, location and abundance
4: Identification and characterization of endometrial macrophages
5: Regulation of macrophage function during the menstrual cycle
6: Endometrial macrophages in women's reproductive health disorders
7: Future directions
8: Conclusions
References

Samanta Antonella Mariani

After defending an experimental thesis on malignant haematopoiesis, Samanta Mariani obtained a Master’s Degree in Medical Biotechnology from the University of Modena and Reggio Emilia (Italy). She then moved to Milan to join an international PhD programme on Cellular and Molecular Biology held by the Vita-Salute San Raffaele University and the Open University of London. During the four years of her PhD in Professor Guido Poli’s laboratory, she worked on HIV-1 biology. After successfully defending her PhD thesis, she decided to move to the United States to experience a new research environment and broaden her scientific expertise. Changing scientific topics between the Master’s and PhD led to her fascination in human haematopoiesis and the desire to find a postdoc in that field. Thus, she joined the laboratory of Professor Bruno Calabretta at the Thomas Jefferson University of Philadelphia. At the end of 2014, she joined Professor Elaine Dzierzak's laboratory for a second postdoc at the University of Edinburgh. Here she worked on different projects focused on steady-state developmental haematopoiesis and immunology. In 2021, she was awarded a Chancellor's Fellowship, a John Goldman Fellowship and entry to the ESAT tenure-track programme at the University of Edinburgh. This allowed her to open up a new line of research on embryonic macrophages and their role in health and disease, with a special focus on normal and malignant foetal/infant haematopoiesis.

Affiliations and expertise

The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ

Luca Cassetta

Dr Cassetta is a co-Founder of Macomics and is an immunologist with in-depth knowledge of human myeloid cell biology applied to different human diseases. He obtained a PhD in immunology at the S.Raffaele Institute in Milan studying the role of macrophage polarization in HIV pathogenesis; he then moved to NY at the Albert Einstein Medical College in the lab of Prof. Jeffrey Pollard where he studied Tumor Associated Macrophages in breast cancer. He then moved to the University of Edinburgh continuing his studies on TAMs where he established his own lab as principal investigator. His extensive experience in human macrophage biology contributed to the development of the Macomics screening platform. Dr Cassetta is an author of multiple publications in high-impact international scientific journals including Cancer Cell, Nature Communications, Journal of Experimental Medicine, Blood, PNAS, Nature Reviews Drug Discovery. He was awarded the Innovation Prize cup 2019 as a young entrepreneur for the spinout company, Macomics. Dr Cassetta joined Macomics full time as VP Immunology in 2021.

Affiliations and expertise

The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ

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