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Elsevier

Occupational Neurotoxicology

  • 1st Edition, Volume 7 - July 15, 2022
  • Latest edition
  • Editors: Michael Aschner, Lucio G. Costa, Roberto G. Lucchini
  • Language: English

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in differ… Read more

Description

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.

Key features

  • Provides updated information about exposure and neurotoxic outcomes
  • Includes indication on new tools for neurobehavioral assessment
  • Covers practical indications on preventive aspects

Readership

Medical doctors, industrial hygienists, toxicologists, risk assessors, occupational health and safety professionals, who are interested in the identification and prevention of work-related neurotoxicty

Table of contents

Preface
Roberto G. Lucchini

1. Current evolution of neurobehavioral methods
Maryse F. Bouchard, Diane S. Rohlman, Carola Tuerk, Hana-May Eadeh, Trisha Saha and W. Kent Anger

2. Cognitive impact of exposure to airborne particles captured by brain imaging
Somaiyeh Azmoun, Jenny Diaz, Cheuk Y. Tang, Megan Horton, Sean A.P. Clouston, Ben J. Luft, Evelyn J. Bromet, Sam Gandy, Donatella Placidi, Claudia Ambrosi, Lorella Mascaro, Carlo Rodella, Barbara Paghera, Roberto Gasparotti, Jeremy W. Chambers, Kim Tieu and Roberto G. Lucchini

3. Clinical evaluation and differential diagnosis of neurotoxic disease
Jonathan Rutchik and Marcia H. Ratner

4. Aerotoxic syndrome: A new occupational disease caused by contaminated cabin air?
G. Hageman, SJ Mackenzie Ross, J. Nihom and G. van der Laan

5. Occupational neurotoxicity of organic solvents
Christoph van Thriel and William K. Boyes

6. Pesticides
Diane S. Rohlman, James R. Olson, Ahmed Ismail, Matthew R. Bonner, Gaafar Abdel Rasoul and Olfat Hendy

7. Diagnosis and management of occupational and environmental carbon monoxide neurotoxicity
Jonathan Rutchik and Marcia H. Ratner

8. Mercury neurotoxicity in gold miners
Maria Elena Crespo-Lopez, Marcus Augusto-Oliveira, Amanda Lopes-Araújo, Letícia Santos-Sacramento, José Rogério Souza-Monteiro, Felipe Farias da Rocha and Gabriela de Paula Arrifano

Product details

  • Edition: 1
  • Latest edition
  • Volume: 7
  • Published: July 24, 2022
  • Language: English

About the editors

Michael Aschner

Serial Volume Editor
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control, FDA, National Academy of Sciences, US Department of Defense), and was a member and chair of the Neurotoxicology and Alcohol study section (NIH). He served as the President of the Society of Toxicology and has previously served as the President of the Academy of Toxicological Sciences and the International Neurotoxicology Association. He has authored (co-authored) >1,100 peer reviewed manuscripts and 110 book chapters, his h-index is 124, and he is a recipient of Honorary Doctorate from the University of Cordoba in Argentina. Research in his lab focuses on: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of methylmercury (MeHg) uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. His studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and expertise
Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

Lucio G. Costa

Serial Volume Editor
Dr. Costa is Professor Emeritus of Toxicology in the Department of Environmental and Occupational Health Sciences at the University of Washington in Seattle. Before joining the University of Washington in 1983 he received a doctorate in Pharmacology from the University of Milano and was a postdoctoral fellow at the University of Texas at Houston. Over the years he served as the Director of the University of Washington Toxicology Program, Director of the Neurotoxicology Research Core of the NIEHS Center in Ecogenetics and Environmental Health, and a Core Faculty of the Environmental and Occupational Epidemiology Training Program and the Environmental Pathology/Toxicology Training Program at the University of Washington. He has also held professorial positions at various Universities in Italy (Parma, Bari, Roma, Pavia, Milano). He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various awards for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. Dr. Costa has been a member of several panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has been teaching classes in pharmacology, toxicology, and neurotoxicology for over 35 years, and has kept an active research program in neurotoxicology, with >500 publications, books and book chapters. The primary focus of his research relates to the toxicology and neurotoxicology of pesticides, environmental contaminants, alcohol, air pollution, and on various aspects of gene-environment interactions in relationship to neurotoxicity and neurodegeneration.
Affiliations and expertise
Professor of Toxicology, University of Washington, Seattle, WA, USA

Roberto G. Lucchini

Serial Volume Editor
Medicine at Mount Sinai, New York. He was also the Director of the World Trade Center Data Center at Mount Sinai and the Director of the NIOSH funded Education and Research Center for the States of New York and New Jersey. In these capacities, he coordinated the epidemiological health surveillance of the workers involved in the clean-up operations after 9/11. Dr. Lucchini was also director of the Selikoff Centers of Occupational Health, the largest center of Occupational Medicine in the USA. Since 2020, Dr Lucchini is a Professor at the School of Public Health, Florida International University, where he continues his research interests with further developments in a highly qualified scientific environment. He has also conducted studies on the risk factors for covid-19 disease severity and mortality, including occupational and environmental exposure to airborne particulates and air pollution. Dr. Lucchini’s research is focused on the health effects of neurotoxic chemicals and the biological mechanisms by which metals, pesticides, persistent organic pollutants, particulate matter and other toxic chemicals can cause injury in the human nervous system, from neurodevelopment to neurodegeneration. He and his team have conducted studies in general populations as well as in occupational groups. With support from Italian National funds, the EU and NIEHS, they have assessed the effects of neurotoxic chemicals across the life span in populations that range in age from early childhood, through adult life to old age. They have also undertaken studies in patients with neurodegenerative diseases and the role of occupational and environmental determinants in aging. These studies are focused in the highly industrialized provinces of Brescia and Taranto and target the exposure to neurotoxic metals including manganese. More recently Dr. Lucchini became involved with the research on the health effect among workers and responders who were exposed to chemicals and intense psychological trauma at the World Trade Center after the 9/11 terroristic attack. He is studying the increased frequency of neurological conditions through the use of fMRI and PET imaging techniques.
Affiliations and expertise
Florida International University, NY, USA

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