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Nutritional Epigenetics

Food-Derived microRNAs in Health and Disease

  • 1st Edition - January 1, 2027
  • Latest edition
  • Editors: Shariful Islam, Jamil Talukder, Saman Fatima, S. Rehan Ahmad
  • Language: English

Nutritional Epigenetics: Food-Derived microRNAs in Health and Disease offers perspective on the role of dietary microRNAs as pivotal epigenetic regulators influencing health trajec… Read more

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Description

Nutritional Epigenetics: Food-Derived microRNAs in Health and Disease offers perspective on the role of dietary microRNAs as pivotal epigenetic regulators influencing health trajectories and disease susceptibility. The book brings together current research on the bioavailability and molecular mechanisms by which plant and food-derived microRNAs modulate gene expression, including their crosstalk with DNA methylation, histone modifications, and gut microbiota. Detailed food-specific chapters examine the epigenetic impact of key dietary sources such as Brassicaceae (crucifers), rice, milk, and fermented products, highlighting their transgenerational and life-stage effects. Practical insights into food processing, culinary traditions, and the design of microRNA-fortified products bridge the gap between bench science and real-world applications. Nutritional Epigenetics equips researchers, clinicians, and industry innovators with a resource that advances the understanding of microRNA-mediated nutritional epigenomics, while guiding the development and safety assessment of microRNA-enhanced functional foods. By integrating molecular biology with population-level evidence and translational strategies, this text fosters the development of novel dietary interventions aimed at optimizing health across the lifespan and mitigating chronic disease risk.

Key features

  • Examines the molecular mechanisms by which dietary microRNAs modulate epigenetic regulation
  • Analyzes the bioavailability and gene-targeting specificity of plant-derived microRNAs
  • Evaluates transgenerational and life-stage impacts of food-derived microRNAs on health outcomes
  • Interprets current epidemiological evidence and regulatory policies relevant to microRNA-enhanced functional foods
  • Develops strategies for designing and implementing microRNA-fortified foods in clinical and commercial contexts

Readership

Researchers in the food sciences specializing in nutrition, specifically epigenetics, molecular nutrition, and functional genomics

Table of contents

Section I – Foundations

1. Roadmap to Nutritional Epigenomics

2. Plant microRNAs – Mammalian Bioavailability & Canonical Targets

Section II – Molecular Mechanisms

3. microRNA–DNA Methylome Crosstalk in Early Embryo

4. Histone Tail Choreography Triggered by Food microRNAs

5. microRNA-Edited Gut Microbiota as an Epigenetic Vector

6. Dietary microRNAs as Bioactive Components: Unique Mechanisms of Cross-Kingdom Regulation, Bioavailability, and Gene Targeting

Section III – Food & Ingredient Focus

7. Brassicaceae microRNAs and Their Transgenerational Cardio-Protection

8. Rice MIR168a: From Seed to Serum Glucose Control

9. Milk Exosomal microRNAs and Neonatal Immune Imprinting

10. Fermented Foods: Live microRNAs and Microbial Co-metabolites

Section IV – Life-Stage & Disease Models

11. Paternal Pre-conception Dietary microRNAs and Offspring Neuro-behavior

12. Maternal Plant microRNA Exposure and Placental Epigenetic Ageing

13. microRNA-Enriched Diets in Adult Cardio-metabolic Disease Reversal

14. Dietary microRNAs and CNS Signaling: Epigenetic Modulation of Neuronal Pathways and Implications for Neurodegenerative and Psychiatric Disease Progression

Section V – Population & Translation
Part A: Evidence and Ethics

15. Human Epidemiological Evidence: microRNA Intake and Methylation Clocks

16. Regulatory and Safety Roadmap for microRNA-Enhanced Functional Foods

17. Emerging Global Regulatory Frameworks for Dietary and Plant-Derived microRNAs in Functional Foods and Supplements (2023–2026 Updates)

18. Challenges, Methodological Limitations, and Regulatory Controversies in Dietary microRNA Research
Part B: Food-System Implementation and Life-Stage Applications

19. Food Matrix Effects on microRNA Stability and Function

20. Impact of Cooking, Processing and Storage on Food microRNAs

21. Culinary Traditions as Epigenetic Modulators – Ancestral Practices to Community Menus

22. Designing microRNA-Enriched Functional Foods

23. Infant, Maternal and Ageing Nutrition Applications of microRNA-Fortified Foods

Product details

  • Edition: 1
  • Latest edition
  • Published: January 1, 2027
  • Language: English

About the editors

SI

Shariful Islam

Professor Shariful Islam, MBBS, MPH, PhD, FESC, ISHF, is a distinguished academic and researcher with a strong focus on nutritional sciences and public health. As a Professor in the Department of Nutritional Sciences, College of Health and Human Sciences, his work centers on the critical role of diet and nutrition in the prevention and management of chronic diseases, particularly cardiometabolic disorders. His multidisciplinary training in medicine, public health, and advanced research enables him to integrate clinical insights with population-level nutrition science.

Prof. Islam’s research is firmly grounded in nutritional epidemiology, with particular emphasis on dietary patterns, nutrient quality, food systems, and lifestyle-based nutritional interventions. He has led and contributed to large-scale population studies examining the impact of diet, salt and fat intake, micronutrient deficiencies, and nutrition transitions on cardiovascular and metabolic health. His scholarly output includes numerous publications in high-impact, peer-reviewed journals, advancing evidence-based nutrition strategies for non-communicable disease prevention.

Equally committed to education, Prof. Islam plays a vital role in teaching nutrition and public health curricula and mentoring graduate students and early-career researchers. He promotes interdisciplinary, data-driven approaches to nutrition research and policy. His recognition as a Fellow of the European Society of Cardiology (FESC) and the International Society of Hypertension (ISHF) underscores his leadership in advancing nutrition-focused strategies for global health improvement.

Affiliations and expertise
Professor Department of Nutritional Sciences College of Health and Human Science, Texas Tech. USA

JT

Jamil Talukder

Dr. Jamil Talukder is an accomplished nutrition and physiology researcher with over two decades of academic, translational, and industry experience spanning human, animal, and veterinary nutrition. His research has made substantial contributions to understanding nutrient transport, digestion, and bioavailability, particularly the regulation of amino acid, glucose, iron, and peptide transporters in the gastrointestinal tract under health and inflammatory conditions. Trained in physiology, Dr. Talukder has published extensively in leading journals, elucidating molecular mechanisms linking diet, inflammation, and intestinal function. His work on bioactive compounds, nutraceuticals, and functional foods has advanced evidence-based nutritional interventions for metabolic and digestive health. In addition to academic research, he has led R&D initiatives translating nutritional science into patented technologies and commercial products. Dr. Talukder has also contributed significantly to nutrition education, mentoring graduate students, and authoring scholarly book chapters, thereby strengthening the interface between fundamental nutrition science, clinical relevance, and applied innovation.

Affiliations and expertise
Director of Research and Development, and Manufacturing, RD Life Sciences, Florida, USA

SF

Saman Fatima

Dr. Saman Fatima is a pharmaceutics-nutrition hybrid scientist whose career sits at the exact intersection this book occupies: delivering food-borne, microRNA-carrying bioactives across the blood–brain and placental barriers while documenting the epigenetic footprints that persist for generations. After earning her Ph.D. in Pharmaceutics from Jamia Hamdard (New Delhi), she pioneered the first antioxidant- and omega-3-loaded nano-emulsions that simultaneously (i) protect endogenous microRNAs from gastric degradation, (ii) ferry them to target tissues, and (iii) remodel DNA-methylation patterns in ischemic brain and fetal liver models—work now cited > 600 times and protected under her granted patent “Protein-assembled nano-vehicle for neuro-nutraceutical delivery” (IPR India 380249). Her interdisciplinary findings appear in Biomaterials, Journal of Nutritional Biochemistry, Epigenomics, and four Elsevier/Springer book chapters on “Nutri-epigenomic nano-delivery,” establishing her as one of the few investigators equally comfortable with RNA-seq analytics, GMP nano-scaling, and regulatory ethics. A recipient of the RESOMER® Award (2018), Young Scientist Award from the Society of Biological Chemists (India), and elected member of the Society for NeuroChemistry India, Dr. Fatima currently leads a translational program on “microRNA-enriched foods for transgenerational resilience” at Jamia Hamdard. She has organized symposia on “Nutri-epigenomics & DOHaD” for the International Society for Micro-nutrients and serves on the editorial boards of Nutrition Research and Frontiers in Pharmacology—Nutraceuticals.

Affiliations and expertise
Assistant Professor, Amity Institute of Pharmacy, Amity University, Noida, India

SA

S. Rehan Ahmad

Dr. S Rehan Ahmad is a multidisciplinary scientist whose research bridges microbiology, medicinal chemistry, neurobiology, and precision medicine. Earning his Ph.D. in Microbiology, his pioneering work explores the pharmacogenomics and microbiome-based modulation of neurodegenerative diseases, with a focus on plant-derived therapeutics and molecular docking-driven drug discovery. His research integrates molecular microbiology, analytical chemistry (HPLC–MS), bioinformatics, and nanobiotechnology to advance novel therapeutic strategies. He holds over 30 patents and has published more than 60 peer-reviewed articles in high-impact journals, including Nature, Elsevier, Wiley, Springer, Frontiers and MDPI. He has edited two books published by Elsevier: The Gut Microbiome in Precision Medicine: From Research to Clinical Practice which focuses on the gut microbiome’s role in health, and Precision Medicine in Neurodegenerative Diseases: From Research to Clinical Practice, covering personalized medicine for neurodegenerative disorders.

His editorial experience is extensive, serving as Academic Editor for PLOS ONE, Editorial Board Member for over 15 international journals, and Guest Editor for JoVE. Recognized for his academic leadership, he serves as Coordinator of the Indira Gandhi National Open University (IGNOU) Study Centre (28166), Centre Superintendent (28166), and Convenor of multiple institutional committees including the Research & Development Cell (RDC), Intellectual Property Rights Cell (IPR), and Institution’s Innovation Council (Ministry of Education, Government of India). His teaching experience spans over 12 years in microbiology, neurobiology, medicinal biochemistry, food chemistry, and bioinformatics, mentoring more than 40 postgraduates and three doctoral researchers.

Affiliations and expertise
Assistant Professor and Head, Department of Microbiology, West Bengal State University, India