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Nucleic Acids
A Natural Target for Newly Designed Metal Chelate Based Drugs
1st Edition - August 20, 2023
Editors: Irshad Ul Haq Bhat, Zakia Khanam
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 5 0 3 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 5 0 4 - 4
Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance… Read more
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Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability.
Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets.
- Focuses on recent advances and methods adopted for generating new metal-based molecules and their interactions with biomolecules, especially nucleic acids
- Addresses challenges for developing new metal-based drugs
- Examines advances in optical techniques for the characterization of metal-based drugs
Researchers in both universities (researching in pharmaceutical science, chemistry, inorganic chemistry) and industries (pharma and biopharma sectors), Graduate students: who are working on drug development or related topics
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Abbreviations
- Introduction
- Chapter 1. Zinc complexes: Their interaction with nucleic acids and other biomolecular targets
- 1. Chemistry of zinc
- 2. Interaction of synthesized zinc complexes with nucleic acids
- 3. Methods of analysis
- 4. Interaction of zinc complexes with biomolecules
- 5. Conclusion
- Chapter 2. Ruthenium complexes: An insight into their interactions with nucleic acids and biomolecules
- 1. Chemistry of ruthenium
- 2. Methods of synthesis
- 3. Methods of analysis
- 4. Uses of metal complexes
- 5. Limitations
- 6. Future prospects
- 7. Conclusions
- Chapter 3. Nucleic acid interactions of copper complexes
- 1. Chemistry of copper
- 2. Methods of synthesis
- 3. Methods of analysis
- 4. Uses of metal complexes
- 5. Limitations
- 6. Future prospects
- 7. Conclusions
- Chapter 4. Recent advances in iron complexes and their interaction with nucleic acids
- 1. Chemistry of iron
- 2. Methods of synthesis
- 3. Methods of analysis
- 4. Uses of metal complexes
- 5. Limitations
- 6. Future prospects
- 7. Conclusions
- Chapter 5. Manganese complexes: Their interaction studies with nucleic acids and biomolecules
- 1. Chemistry of manganese
- 2. Methods of synthesis
- 3. Methods of analysis
- 4. Applications of manganese complexes
- 5. Limitations
- 6. Future prospects
- 7. Conclusion
- Index
- No. of pages: 300
- Language: English
- Published: August 20, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128205037
- eBook ISBN: 9780128205044
IH
Irshad Ul Haq Bhat
Dr. Irshad Ul Haq Bhat (Assistant Professor), Department of Chemistry, College of Science, University of Bahrain, Bahrain. Dr. Bhat completed his Ph.D. in 2008 from Aligarh Muslim University, India, and was awarded a Postdoctoral Fellowship (2009–2012) from the University of Science Malaysia. Dr. Bhat has 15 years of research and teaching experience. He has completed various research grants, both as the main as well as co=researcher, and has received the Service Excellence Award from the University of Malaysia Kelantan, Malaysia. He has supervised students at the undergraduate and postgraduate levels. He has presented his research work in more than 20 national and international conferences. He has published more than 50 high-impact-factor research articles including highly cited review articles along with eight book chapters and served as an editorial member and reviewer of 10 journals. His research interest includes bioinorganic chemistry (metal-based drugs), metal chelate–DNA interaction, nanocatalysis, biocomposites, and nanoparticle synthesis.
Affiliations and expertise
Senior Lecturer, Faculty of Earth Science, University of Malaysia Kelantan, Campus Jeli, Kelantan, MalaysiaZK
Zakia Khanam
Dr. Zakia Khanam received her Ph.D. in 2009 from Aligarh Muslim University, India. She completed her postdoctoral fellowship (2011) from the School of Chemical Sciences, University of Science Malaysia. She has served as a Senior Lecturer in the Faculty of Agro Based Industry, University of Malaysia Kelantan, Malaysia. She has 8 years of research and teaching experience and served as a committee member in various faculty committees. She has received awards for publications at the University of Malaysia Kelantan and University of Science Malaysia. Dr. Khanam has published more than 25 research articles, six book chapters, monographs, and several proceedings. She is actively involved in reviewing articles from various publications and has served as a section editor, guest editor, and editorial board member of several journals. She has presented and contributed her research work in 38 conferences and trained students for thesis writing in various workshops as an invited speaker including the Health, Herbs and Beauty Bio-Kelantan international carnival: Conference and Exhibition. Her research interests are phytochemical investigations, pharmacological investigation of active compounds, DNA cleavage studies, and polymer sciences.
Affiliations and expertise
Junior Research Fellow: Chemical Research Unit, Department of Research in Unani Medicine, Aligarh Muslim University, Aligarh, U.P., India