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Novel Therapeutic Approaches Targeting Oxidative Stress
- 1st Edition - February 18, 2022
- Editors: Pawan Kumar Maurya, Imteyaz Qamar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 9 0 5 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 9 0 6 - 8
Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative… Read more
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Request a sales quoteNovel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored.
The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.
- Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer
- Covers a range of therapeutic approaches to target oxidative stress
- Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress
- Features case studies illustrating the targeting of oxidative stress
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Acknowledgments
- Chapter 1: Novel therapeutic approaches targeting oxidative stress in mood disorders
- Abstract
- 1: Introduction
- 2: The production of ROS in the brain
- 3: The elimination of ROS in the brain
- 4: Oxidative stress in the brain
- 5: Markers of oxidative stress and mood disorders
- 6: Antioxidant treatments in mood disorders
- 7: Conclusions
- Chapter 2: Ferroptosis: Oxidative stress and pathophysiology
- Abstract
- Acknowledgment
- Conflict of interest
- 1: Introduction
- 2: Immunology
- 3: Conclusion
- Chapter 3: Oxidative stress and its biological significance
- Abstract
- 1: Introduction
- 2: Oxidative stress in 4-hydroxynonenal (HNE) leading to apoptosis
- 3: Antioxidant supplementation increasing tumorigenesis
- 4: Regulation of the cell cycle in the oxidative state
- 5: Viral infections and oxidative stress
- 6: Epigenetic factors and carcinogenesis
- 7: Extracellular superoxide angles and apoptosis
- 8: Extreme oxidative stress with T cells
- 9: Oxidative stress in lung cancer
- 10: Inflammation and lung cancer
- 11: Oxidative stress in breast cancer
- 12: Response to therapy
- Chapter 4: Novel therapeutic approaches targeting oxidative stress in aging
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Hallmarks of aging
- 3: Causes of aging
- 4: Age-associated diseases
- 5: Novel therapeutic approaches
- 6: Liposomes
- 7: Conclusion
- Chapter 5: Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases
- Abstract
- Acknowledgment
- Conflicts of interest/competing interests
- 1: Introduction
- 2: Dimensions of aging in the investigation of neurodegeneration
- 3: Clinical implications
- 4: Implications for research
- Chapter 6: The role of oxidative stress in kidney diseases
- Abstract
- 1: Introduction
- 2: Kidney architecture at the cellular level
- 3: Nephrotoxicity and renal pathology
- 4: Classification of kidney diseases
- 5: The chemical species of oxidative stress
- 6: Cellular antioxidant defense system
- 7: Sources of ROS in the kidneys
- 8: Reactive oxygen species and kidney diseases
- 9: Oxidative stress in the renal tubules
- 10: Oxidative stress in the glomerulus
- 11: Oxidative stress in the renal vasculature
- 12: Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury
- Chapter 7: The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome
- Abstract
- 1: Introduction
- 2: Oxidative stress
- 3: Endothelial dysfunction and oxidative stress
- 4: Molecular effects of oxidative stress
- 5: Oxidative stress in coronary artery disease
- 6: Coronary microvascular dysfunction
- 7: Oxidative stress and lipids, protein, and DNA damage
- 8: Therapies for oxidative stress-associated cardiovascular diseases
- 9: Conclusions
- Chapter 8: Biosensors in the detection of oxidative stress using discovered biomarkers
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Biosensors
- 3: Biomarkers
- 4: Overview of discovered biomarkers for oxidative stress
- 5: Management of oxidative stress conditions
- 6: Research trends and future challenges in development of biosensors
- 7: Conclusion
- Chapter 9: Biochemical approaches/methods in the detection of free radicals
- Abstract
- 1: Introduction
- 2: In vitro methods
- 3: Chemiluminescence-derived methods using luciferine derivatives
- 4: Reduction of cytochrome c
- 5: NBT tests
- 6: Aconitase inactivation
- 7: Boronates
- 8: In vivo methods
- 9: Redox potential of the GSH/GSSG couple
- 10: Measurement of F2-isoprostanes as indicators of lipid per-oxidation
- 11: Reporter assays
- 12: Fluorescent protein-based methods
- 13: Analytical methods
- 14: Fluorescence-dependent methods
- 15: Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy
- 16: Spin trapping technique
- 17: Immuno-spin trapping of macromolecules
- 18: Combined IST and mMRI detection
- 19: Pulse radiolysis
- 20: Chromatography-based techniques
- 21: Other biochemical methods
- 22: Summary
- Chapter 10: Novel therapeutic approaches targeting oxidative stress in breast and lung cancer
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Epidemiology and risk factors
- 3: Role of oxidative stress in cancer pathophysiology
- 4: Classification of breast and lung cancer
- 5: Conventional therapies for cancer treatment
- 6: Novel approaches for cancer therapeutics
- 7: Therapeutic approaches targeting oxidative stress in cancer
- 8: Conclusion
- 9: Future perspective
- Chapter 11: Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases
- Abstract
- 1: Introduction
- 2: Anti-oxidants working principle and pathways
- 3: Types of anti-oxidants and their mode of action
- 4: Traditional approaches
- 5: Innovative approaches in nano delivery of natural and synthetic anti-oxidants
- 6: Limitations and future perspectives of novel drug delivery systems at clinical translation level
- 7: Summary
- Index
- No. of pages: 292
- Language: English
- Edition: 1
- Published: February 18, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323909051
- eBook ISBN: 9780323909068
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Pawan Kumar Maurya
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