Novel Therapeutic Advances in Glioblastoma
- 1st Edition, Volume 151 - May 20, 2020
- Imprint: Academic Press
- Editors: Igor Bryukhovetskiy, Aruna Sharma, Zhiqiang Zhang, Hari Shanker Sharma
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 1 1 4 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 1 1 5 - 1
Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presentin… Read more
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Request a sales quoteNovel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promising strategies of glioblastoma treatment: personalized genotoxic therapy and stem cell transplantation, Extracellular matrix and biocompatible materials in glioblastoma treatment, Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the International Review of Neurobiology series
- Updated release includes the latest information on glioblastomas
Undergraduates, graduates, academics and researchers in the field of Glioblastomas
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- References
- Acknowledgments
- Chapter One Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- Abstract
- 1 Introduction
- 2 The blood-brain barrier and brain tumors
- 3 The blood-tumor barrier structure and function
- 4 Therapeutic strategies for brain tumor
- 5 Nano-drug delivery for brain tumor therapy
- 6 Theranostic nanomedicine for brain tumor therapy
- 7 Our experiments with nanowired delivery of drugs in experimental glioma
- 8 Possible mechanisms of nanowired drug delivery on neuroprotection in rat glioma
- 9 Conclusion and future direction
- Acknowledgments
- References
- Chapter Two Personalized therapy and stem cell transplantation for pro-inflammatory modulation of cancer stem cells microenvironment in glioblastoma: Review
- Abstract
- 1 Introduction
- 2 Modern standards for GBM treatment and reasons for their inefficiency
- 3 BBB and treatment resistance
- 4 Nano-based drug delivery
- 5 Genotoxic pharmacotherapy and methods for optimization
- 6 CSCs and personalized therapy
- 7 Normal stem cells and treatment resistance
- 8 CSCs and well-differentiated non-tumor cells in GBM
- 9 Pro-inflammatory modification of the tumor microenvironment as a primary method of regulating glioblastoma cancer stem cells
- 10 Novel biomedical technologies for treatment of GBM
- 11 Conclusion
- References
- Chapter Three New advances on the inhibition of Siwei Xiaoliuyin combined with Temozolomide in glioma based on the regulatory mechanism of miRNA21/221
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- References
- Chapter Four Hydrogels based on modified pectins capable of modulating neural cell behavior as prospective biomaterials in glioblastoma treatment
- Abstract
- 1 Introduction
- 2 Material and method
- 3 Results
- 4 Discussion
- 5 Conclusions
- References
- Chapter Five Fluorescein-guided surgery for spinal gliomas: Analysis of 220 consecutive cases
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Ependymal tumors
- 5 Discussion
- 6 Conclusions
- References
- Chapter Six Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- References
- Chapter Seven Surgical treatment of low-grade brain tumors associated with epilepsy
- Abstract
- 1 Introduction
- 2 Methods
- 3 Results
- 4 Discussion
- 5 Conclusion
- References
- Chapter Eight Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- References
- Chapter Nine Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- References
- Chapter Ten Transforming growth factor-β mimics the key proteome properties of CD133− differentiated and CD133+ cancer stem cells in glioblastoma
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- Competing interests
- References
- Chapter Eleven Inhibitory effect of Siwei Xiaoliuyin on glioma angiogenesis in nude mice
- Abstract
- 1 Materials and methods
- 2 Determination of serum VEGF and ES
- 3 Tumor tissue MVD determination
- 4 Result
- 5 Discussion
- References
- Chapter Twelve Advanced multimodal imaging in differentiating glioma recurrence from post-radiotherapy changes
- Abstract
- 1 Introduction
- 2 Advanced MR imaging in identifying glioma recurrence and post-radiotherapy changes
- 3 PET/CT
- 4 Discussion
- 5 Conclusion
- References
- Chapter Thirteen Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review
- Abstract
- 1 Introduction
- 2 Existing standards of glioblastoma (GBM) treatment
- 3 GBM genetic signatures
- 4 Mutation-based GBM therapy
- 5 Targeted GBM therapy and ways of increasing its efficiency
- 6 Fascaplysin alkaloids and their antitumor properties
- 7 New prospective derivatives of Fascaplysin alkaloids
- 8 Conclusion
- References
- Chapter Fourteen 3-Bromofascaplysin is a prospective chemical compound for developing new chemotherapy agents in glioblastoma treatment
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Research design
- 4 Flow cytometry
- 5 Results
- 6 Discussion
- References
- Edition: 1
- Volume: 151
- Published: May 20, 2020
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128211144
- eBook ISBN: 9780128211151
IB
Igor Bryukhovetskiy
Igor Bryukhovetskiy is at Far Eastern Federal University, Russia
Affiliations and expertise
Far Eastern Federal University, RussiaAS
Aruna Sharma
Aruna Sharma, MD is currently Secretary of Research at Uppsala University Hospital, Uppsala University, Sweden. She obtained her Bachelor of Science in 1971 and trained in Indian Medicine up to 1977 and engaged in medical research from 1978 to 1986 in India on hyperthermia induced brain dysfunction in the lab of Hari Sharma and Prasanta Kumar Dey under University Grants Commission and Indian Council of Medical Research
Her main interest is now focused on Indian Medicinal drugs and their effects on the Central Nervous System Function, toxicology, neurorepair and neuroprotection. She is also investigating neurotoxicological profiles of many Ayurvedic traditional drugs with special reference to those containing metal oxide or metal ashes.
Affiliations and expertise
Secretary of Research, Uppsala University Hospital, Uppsala University, SwedenZZ
Zhiqiang Zhang
Zhi-Qiang Zhang M.D. & Ph.D., Professor of Neurosurgery, is currently the director of department of Neurosurgery Guangdong Provincial of Chinese Medicine Hospital，the Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Professor Zhang has been engaged in clinical work, teaching and scientific research in neurosurgery for more than 30 years. He has extremely valuable experience on the treatment and research of brain tumors with integrated Chinese and Western medicine. Dr. Zhang is currently the deputy director of the China Branch of the International Society for Neurorestoration, the deputy director of the Department of Neurorestoration of the Chinese Medical Association, the chairman of the Department of Neurorestoration of the Guangdong Medical Association, the chairman of the Guangdong Provincial Neuro-oncology Committee of Integrative Chinese and Western Medicine. Dr. Zhang has published over 40 research papers, and presided over in a series of clinical and basic research projects and won provincial and municipal scientific research progress awards of China.
Affiliations and expertise
Guangzhou University of Chinese Medicine, ChinaHS
Hari Shanker Sharma
Dr. Hari Shanker Sharma, Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) is currently working in Uppsala University Hospital, Department of Surgical Sciences, Division of Anesthesiology & Intensive Care Medicine, Uppsala University, Sweden. Dr Sharma obtained his Masters Degree from Bihar University with special expertise in Cell Biology in 1976 and was awarded the Gold Medal of Bihar University for securing 1st position in the 1st Class. Dr Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist, by training in the Department of Physiology, Institute of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D. in 1982 on “Blood-Brain Barrier in Stress.” After carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction (1982–1987), Dr Sharma joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government (1989–1991) to work on hyperthermia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (a living “Legend in Neuropathology in Europe”). Dr Sharma again joined Uppsala University and established a network of collaboration on “Experimental CNS Injury Research Group” as a lead investigator with eminent collaborators in various parts of Europe, USA, and Australia (1991–). On his work on hyperthermia Dr Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 and selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. On his meticulous works on the Blood Brain barrier and Brain edema (2000–2003) Dr. Sharma earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004. Currently his main research interest is Neuroprotection and Neuroregeneration, in relation to the Blood-brain barrier in stress, trauma, and drugs of abuse in health and disease. Dr. Sharma on his research on brain pathology and neuroprotection in different models received the prestigious award from The Laerdal Foundation of Acute Medicine, Stavanger, Norway, in 2005 followed by Distinguished International Scientists Collaboration Award by National Institute on Drug Abuse (NIDA), Baltimore, MD (2006–2008). His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP), and Awarded during their VI Annual Meeting in Lisbon, September 9–12, 2008. His recent research is aimed to find out the role of nanoparticles in Neurodegeneration and Neuroprotection using various treatment strategies that is supported by European Aerospace Research and Development (EOARD), London, UK and US Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Oh, USA. On his works on Blood–brain barrier in hypertension and diabetes together with Romanian colleagues, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania awarded Dr. Sharma with Honorary Doctorate of Medical Sciences in 2009. Dr Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan, November 2011. His works on Nanoneuroscience and development of nanomedicine to treat the CNS injuries has won accolades at various Government and International Scotties or Organization across the World. Accordingly Dr Sharma was decorated with the most prestigious ”Hind Rattan Award 2012” on the eve of Republic Day of India in January 2012 and Mahatma Gandhi Pravasi Gold Medal in October 2012 in House of Lords, London, UK. Dr Sharma was also invited to organize and chair Nanosymposium in Society for Neuroscience meetings in Chicago (2009), San Diego (2010), Washington DC (2011) and New Orleans (2012). Dr Sharma has published over 380 research papers, 75 reviews, 12 monographs, and 70 international book chapters and edited 15 book volumes.
Affiliations and expertise
Professor, Uppsala University, SwedenRead Novel Therapeutic Advances in Glioblastoma on ScienceDirect