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Novel Drug Delivery Systems in the management of CNS Disorders

  • 1st Edition - September 27, 2024
  • Latest edition
  • Editors: Pooja A Chawla, Raimar Loebenberg, Kamal Dua, Vinay Parikh, Viney Chawla
  • Language: English

Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various d… Read more

Description

Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others.
The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies.
This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system.

Key features

  • Consolidates current state of the art research into a single book volume
  • Presents the challenges of drug delivery to the CNS in a comprehensive way
  • Covers the most relevant CNS conditions and diseases
  • Provides future perspectives and the most active research areas in this fast-moving field

Readership

Academic or pharma industry researcher (Scientists). Graduate students in pharmaceutical sciences as a reference text

Table of contents

Part I – Introduction to Drug delivery to the CNS

1. General physiology and function of brain
Anoop Kumar I

2. Drug Delivery to Brain: Formulation Challenges and Potential Approaches
Ashish Baldi, Manisha Kumari and Akshay Kumar

3. Possible targets in the management of various CNS disorders
Viney Chawla, Pooja A. Chawla, Ankur Kumar and Bhupender Nehra

4. Antioxidants and their possible benefits in neurodegeneration
Pooja A. Chawla, Viney Chawla, Keshav Taruneshwar Jha and Gouranga Sundar Roy

5. Prodrug approaches for delivering CNS active agents
Pooja A. Chawla, Viney Chawla, Nikita Sharma and Debashree Debashish Das

6. Traditional practices in CNS drug delivery
R K Narang and Pooja A. Chawla

7. Emerging need of Novel Drug Delivery Systems in management of CNS disorders
Viney Chawla, Pooja A. Chawla, Neha Jain, Manisha Pandey, Ms Triveni and Aditi Sinha

8. Nose to brain drug delivery through advanced Drug Delivery Systems
Monica Gulati

9. PBPK modeling for CNS Delivery
NAGENDRA SINGH CHAUHAN
Part II – Novel Drug Delivery Systems to specific CNS Disorders

10. Superparamagnetic Iron Oxide Nanoparticles and their Potential Role in the Diagnosis and Therapeutics of Various Neurological Disorders
Bhupinder Singh Bhoop, Anjali Pant, Gurpal Singh, Ravi Pratap Barnwal, Sumant Saini and Atul Jain

11. Novel Drug Delivery Systems in treating epilepsy
REYAZ HASSAN, Jasreen Uppal and Apporva Chawla

12. Novel Drug Delivery Systems in the management of Parkinson’s Disease
Vimal Arora

13. Role of Novel Drug Delivery Systems in managing Alzheimer’s Disease
Viney Chawla, Pooja A. Chawla, Ankur Kumar, Bhupender Nehra, Ms Chahat and Abhimannu Shome

14. Novel Drug Delivery Systems in the management of Huntington’s Disease
Monica Gulati

15. Novel Drug Delivery Systems in the management of multiple sclerosis
Dileep Kumar and Gadde Shareena

16. Role of Novel Drug Delivery Systems in delivering antidepressant drugs to the brain
Pooja A. Chawla, Dilpreet Singh, Viney Chawla, Kamal Dua, Amrinder Singh, Ms Amisha and Namandeep Raj

17. Delivering cancer chemotherapeutics to the brain through Novel Drug Delivery Systems
Pooja A. Chawla

18. Novel Drug Delivery Systems in the management of Schizophrenia
Dileep Kumar and Gadde Shareena

19. Prospects of Novel Drug Delivery Systems in treating cerebral palsy
Molakpogu Ravindra Babu, Sukriti Vishwas, Monica Gulati, Kamal Dua, Sachin Kumar Singh, Prathap Madeswara Gupta and Palakurthi Yanadaiah

20. Novel Treatment in Managing Autism
Yadu Nandan Dey, Dharmendra Kumar, Manju Singh and Deependra Singh

21. Novel Drug Delivery Systems in amyotrophic lateral sclerosis
Devidas S. Bhagat, Pooja A. Chawla, Gurvinder S. Bumbrah, Dattatraya Pansare, Bapu R Thorat and Digambar D Gaikwad

22. Novel Drug Delivery Systems in cerebral vascular disorders, transient ischaemic attack and stroke interventions
Dharmendra Kumar, Deependra Singh and Manju Singh

23. Treating meningitis through Novel Drug Delivery Systems
NAGENDRA SINGH CHAUHAN

24. Treatment of CNS infections in AIDS positive patients through Novel Drug Delivery Systems
SS Pancholi, Alok Shiomurti Tripathi and Partha Saha

25. Novel Drug Delivery Systems in the management of myasthenia gravis
Dharmendra Kumar

26. Etiology and Treatment Challenges for Neurotraumatic and Psychiatric Disorders
Mohd. Farooq Shaikh and Alina Arulsamy

27. Trends in delivery of drugs to brain for treatment of neuropathy
Sukhbir Singh, Neelam Sharma, Ishrat Zahoor and Sandeep Arora

28. Delivery of antimigraine drugs to brain through Novel Drug Delivery Systems
Manisha Pandey

29. Treatment of heavy metal induced neurotoxicity via advanced drug delivery systems
Arun Kumar, Mr Abhinav, Mahesh Rachamalla, Mohammad Ali, Sneha Navin, DHRUV KUMAR and Ashok Kumar Ghosh
Part III – Clinical Trials and Future Prospects

30. Exploring the potential of artificial intelligence in drug delivery to brain
Vimal Arora

31. Advanced Drug Delivery Systems in the Management of CNS Disorders
Shamsher Singh, Pooja A. Chawla, Md Reyaz Alam and Anjalee Bhratee

32. Future prospects and Challenges to CNS drug delivery
Sushama Talegaonkar Sr. and Monalisa Mishra

Product details

  • Edition: 1
  • Latest edition
  • Published: October 1, 2024
  • Language: English

About the editors

PC

Pooja A Chawla

Dr. Pooja A Chawla is working as a Professor, at the University Institute of Pharmaceutical Sciences, Baba Farid University of Health Sciences, Faridkot, Punjab, India. She has 22 years of experience in the research, discovery, and development of biologically active pharmaceuticals. Dr. Chawla holds a PhD degree in Pharmaceutical Sciences with a specialization in Pharmaceutical Chemistry and has published 6 books, 25 book chapters, and more than 150 papers in national/international journals and is serving as a reviewer for international journals of repute. Dr. Pooja is also privileged to serve as guest editor of two reputed journals CNS & Neurological Disorders - Drug Targets IF 2.8 and Current Organic Chemistry IF 2.5) of Bentham Sciences. She has been appointed as Academic editor of PLOS ONE journal IF 3.2 and recently she has been appointed as Assistant editor for Health Sciences Review Journal by Elsevier publishers. She has guided more than 60 postgraduate projects and her research team consists of 6 Masters and 4 Doctoral research scholars. Her area of research interest focuses on the design and synthesis of various heterocyclic moieties including 4-Thiazolidinones, 2,4-Thiazolidiedione, Coumarin, Pyrazolines, Schiff’s base derivatives to name a few for the discovery of medicinally important agents as anticonvulsants, antidepressants, anticancer, anti Alzheimer’s agents. She is well-versed with method development and validation and guiding research scholars in this field.

Affiliations and expertise
Professor, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India.

RL

Raimar Loebenberg

Dr. Raimar Löbenberg holds a BSc in pharmacy from the Johannes Gutenberg-University in Mainz, Germany and PhD in pharmaceutics from the Johann Wolfgang Goethe-University in Frankfurt. He joined the University of Alberta in 2000. His research interests are in Biopharmaceutics to predict the oral performance of drugs and botanicals and inhalable nanoparticles to treat lung diseases like cancer or tuberculosis. He is founder and director of the Drug Development and Innovation Centre at the University of Alberta. He was president of the Canadian Society for Pharmaceutical Sciences 2014 & 2015. He is member of the United States Pharmacopeia Dietary Supplement Expert Committee. He is Vice Chair of the Specialty Committee of Traditional Chinese Medicine in Pharmaceutics of the World Foundation of Chinese Medicine Science. He is member of the Health Canada Scientific Advisory Committee on Pharmaceutical Sciences and Clinical Pharmacology.

Affiliations and expertise
Professor, Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Canada

KD

Kamal Dua

Dr. Kamal Dua is an Associate Professor in the Discipline of Pharmacy at the Graduate School of Health, University of Technology Sydney (UTS), Australia. He has research experience of over 13 years in the field of drug delivery systems targeting inflammatory diseases. Dr. Dua is also a Node Leader of Drug Delivery Research in the Centre for Inflammation at Centenary Institute/UTS, where the targets identified from the research projects are pursued to develop novel formulations as the first step towards translation into clinics. Dr. Dua research in two complementary areas; drug delivery and immunology, specifically addressing how these disciplines can advance one another, helping the community to live longer and healthier. This is evidenced by his extensive publication record in reputed journals. Dr. Dua’s research interests focus on harnessing the pharmaceutical potential of modulating critical regulators such as Interleukins and microRNAs and developing new and effective drug delivery formulations for the management of chronic airway diseases. He has published more than 100 research articles in peer-reviewed international journals and authored or co-authored four books. He is an active member of many national and international professional societies.

Affiliations and expertise
Associate Professor, University of Technology Sydney (UTS), Discipline of Pharmacy, Graduate School of Health, Australia

VP

Vinay Parikh

Vinay Parikh is an Associate Professor in the Department of Psychology at Temple University (Philadelphia). He also serves as the Director of Neuroscience Program in Temple’s College of Liberal Arts and provides strategic leadership, direction, and guidance for all educational and professional activities in the program. Dr. Parikh has successfully directed multiple research projects, resulting in notable contributions to the understanding of neural mechanisms underlying cognitive decline in age-related neurodegenerative and psychiatric disorders. His research has also opened new avenues to develop cognition therapies. Dr. Parikh has published more than 90 scientific articles and book chapters in areas of systems and behavioral neuroscience, biological psychiatry, and pharmacology, and serves on several editorial boards of journals. He also regularly serves on scientific advisory and review committees of numerous biomedical research agencies including the National Institute of Health, Alzheimer’s Association, and Michael J Fox Foundation.

Affiliations and expertise
Associate Professor, Department of Psychology and Neuroscience Program, Temple University, Philadelphia, United States of America

VC

Viney Chawla

Dr. Viney Chawla is working as Professor and Principal at University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Punjab, India, He has 25 Years of experience in the research, formulation and development of solid lipid nanoparticles, microspheres, nanostructured lipid carriers. Dr. Chawla holds a Ph D Degree in Pharmaceutics and has Published 3 Books, 30 Book Chapters and more than 100 Papers in National/International Journals and is serving as a Reviewer for International Journals of repute. He has guided 40 Post Graduate Projects and his research team consists of 9 Masters and 4 Doctoral Research Scholars.

Affiliations and expertise
Professor and Principal, Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India

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