Novel Bioproducts through Metabolic Engineering of Secondary Metabolites
- 1st Edition - December 1, 2025
- Latest edition
- Editors: Yogesh K. Ahlawat, Pawan K. Jaiwal, Jaya Prakash Yadav, Nisha Sharma
- Language: English
Novel Bioproducts through Metabolic Engineering of Secondary Metabolites delivers an in-depth exploration of the rapidly advancing field of metabolic engineering, focusing on sec… Read more
Novel Bioproducts through Metabolic Engineering of Secondary Metabolites delivers an in-depth exploration of the rapidly advancing field of metabolic engineering, focusing on secondary metabolites and their transformative impact on industrial innovation. The book begins by outlining the essential roles secondary metabolites play in nature, their diversity, and their growing significance in both industrial and medical applications. Readers are introduced to the foundational principles of metabolic engineering, setting the stage for a thorough examination of biosynthetic pathways, strain improvement, and optimization strategies that are vital for developing new bioproducts.
Beyond these fundamentals, the book highlights rational pathway design, the development of industrial enzymes and chemicals, and the integration of state-of-the-art technologies in metabolic engineering. It wraps up with a forward-looking roadmap featuring emerging trends such as CRISPR and genome editing, artificial intelligence applications, and the dynamic evolution of synthetic biology and the bioeconomy—making it an essential resource for researchers and professionals in the field.
Beyond these fundamentals, the book highlights rational pathway design, the development of industrial enzymes and chemicals, and the integration of state-of-the-art technologies in metabolic engineering. It wraps up with a forward-looking roadmap featuring emerging trends such as CRISPR and genome editing, artificial intelligence applications, and the dynamic evolution of synthetic biology and the bioeconomy—making it an essential resource for researchers and professionals in the field.
- Provides detailed coverage of the fundamentals and latest developments in secondary metabolites and metabolic engineering
- Explores the tools and technologies for metabolic engineering for bioproduction or biosynthesis
- Highlights case studies and applications of metabolic engineering in product development
- Addresses both technical and socioeconomic aspects
- Offers a timely exploration of emerging ethical and regulatory considerations in biotechnology and synthetic biology
researchers, academics, and professionals in the fields of biotechnology, synthetic biology, and industrial bioproducts
1: Introduction to Secondary Metabolites
1.1 The Role of Secondary Metabolites in Nature
1.2 Overview of Secondary Metabolite Classes
1.3 Importance of Secondary Metabolites in Industry and Medicine
2: Fundamentals of Metabolic Engineering
2.1 Introduction to Metabolic Pathways
2.2 Tools and Techniques in Metabolic Engineering
2.3 Systems Biology and Omics Technologies
2.4 Synthetic Biology in Metabolic Engineering
3: Biosynthetic Pathways of Secondary Metabolites
3.1 Terpenoids: Pathways and Products
3.2 Alkaloids: Biosynthesis and Biotechnological Production
3.3 Phenolics and Polyketides: Engineering for Novel Properties
4: Strain Development and Optimization
4.1 Microbial Hosts for Metabolic Engineering
4.2 Genetic Tools for Strain Improvement
4.3 Fermentation Process Optimization
4.4 Scale-Up Challenges and Strategies
5: Metabolic Engineering for Pharmaceutical Products
5.1 Production of Anticancer Compounds
5.2 Engineering Pathways for Antibiotics Production
5.3 Metabolic Engineering for Antiviral and Antimalarial Drugs
6: Industrial Enzymes and Chemicals from Metabolic Engineering
6.1 Enzymes for Industrial Applications
6.2 Bio-based Chemicals and Their Industrial Relevance
6.3 Case Studies: Biofuel and Bioplastic Production
7: Nutraceuticals and Functional Foods
7.1 Engineering Probiotics for Health Benefits
7.2 Metabolic Engineering for Vitamin Production
7.3 Enhancement of Nutritional Value in Crops
8: Environmental and Agricultural Applications
8.1 Phytoremediation: Metabolic Engineering for Environmental Cleanup
8.2 Pest-resistant Crops through Metabolic Pathway Modifications
8.3 Improving Crop Yield and Stress Tolerance
9: Engineering Fungal Systems for Secondary Metabolite Production
9.1 Diversity of fungal secondary metabolites and their biotechnological potential.
9.2 Approaches for engineering fungal hosts for improved secondary metabolite production.
9.3 Harnessing fungal diversity for novel bioproduct discovery
10: Tools and Technologies for Metabolic Engineering for Bioproduction or Biosynthesis
10.1 Overview of omics technologies for systems-level analysis.
10.2 Advances in genome editing tools for precise genetic manipulation.
10.3 Integration of multi-omics data for holistic understanding and engineering of metabolic pathways.
11: Engineering Plant Systems for Secondary Metabolite Production
11.1 Challenges and opportunities in engineering plant systems for secondary metabolite production. 11.2 Strategies for enhancing metabolic flux and storage of secondary metabolites.
11.3 Case studies illustrating successful engineering of plant systems
12: Rational Design of Pathway Modification
12.1 Approaches for rational pathway modification in secondary metabolite biosynthesis
12.2 Predictive modeling and computational tools for pathway optimization
12.3 Case studies demonstrating successful rational design strategies
13: Regulatory, Safety, and Ethical Considerations
13.1 Regulatory Framework for Genetically Engineered Products
13.2 Biosafety and Risk Assessment
13.3 Ethical Implications of Synthetic Biology and Metabolic Engineering
14: Case Studies in Metabolic Engineering
14.1 Success Stories of Metabolic Engineering in Industry
14.2 Addressing bottlenecks and limitations in current metabolic engineering approaches
14.3 Opportunities for interdisciplinary collaboration and innovation
15: Future Perspectives and Emerging Trends
15.1 Advances in CRISPR and Genome Editing Technologies
15.2 Artificial Intelligence and Machine Learning in Metabolic Engineering
15.3 The Future of Synthetic Biology and Bioeconomy
1.1 The Role of Secondary Metabolites in Nature
1.2 Overview of Secondary Metabolite Classes
1.3 Importance of Secondary Metabolites in Industry and Medicine
2: Fundamentals of Metabolic Engineering
2.1 Introduction to Metabolic Pathways
2.2 Tools and Techniques in Metabolic Engineering
2.3 Systems Biology and Omics Technologies
2.4 Synthetic Biology in Metabolic Engineering
3: Biosynthetic Pathways of Secondary Metabolites
3.1 Terpenoids: Pathways and Products
3.2 Alkaloids: Biosynthesis and Biotechnological Production
3.3 Phenolics and Polyketides: Engineering for Novel Properties
4: Strain Development and Optimization
4.1 Microbial Hosts for Metabolic Engineering
4.2 Genetic Tools for Strain Improvement
4.3 Fermentation Process Optimization
4.4 Scale-Up Challenges and Strategies
5: Metabolic Engineering for Pharmaceutical Products
5.1 Production of Anticancer Compounds
5.2 Engineering Pathways for Antibiotics Production
5.3 Metabolic Engineering for Antiviral and Antimalarial Drugs
6: Industrial Enzymes and Chemicals from Metabolic Engineering
6.1 Enzymes for Industrial Applications
6.2 Bio-based Chemicals and Their Industrial Relevance
6.3 Case Studies: Biofuel and Bioplastic Production
7: Nutraceuticals and Functional Foods
7.1 Engineering Probiotics for Health Benefits
7.2 Metabolic Engineering for Vitamin Production
7.3 Enhancement of Nutritional Value in Crops
8: Environmental and Agricultural Applications
8.1 Phytoremediation: Metabolic Engineering for Environmental Cleanup
8.2 Pest-resistant Crops through Metabolic Pathway Modifications
8.3 Improving Crop Yield and Stress Tolerance
9: Engineering Fungal Systems for Secondary Metabolite Production
9.1 Diversity of fungal secondary metabolites and their biotechnological potential.
9.2 Approaches for engineering fungal hosts for improved secondary metabolite production.
9.3 Harnessing fungal diversity for novel bioproduct discovery
10: Tools and Technologies for Metabolic Engineering for Bioproduction or Biosynthesis
10.1 Overview of omics technologies for systems-level analysis.
10.2 Advances in genome editing tools for precise genetic manipulation.
10.3 Integration of multi-omics data for holistic understanding and engineering of metabolic pathways.
11: Engineering Plant Systems for Secondary Metabolite Production
11.1 Challenges and opportunities in engineering plant systems for secondary metabolite production. 11.2 Strategies for enhancing metabolic flux and storage of secondary metabolites.
11.3 Case studies illustrating successful engineering of plant systems
12: Rational Design of Pathway Modification
12.1 Approaches for rational pathway modification in secondary metabolite biosynthesis
12.2 Predictive modeling and computational tools for pathway optimization
12.3 Case studies demonstrating successful rational design strategies
13: Regulatory, Safety, and Ethical Considerations
13.1 Regulatory Framework for Genetically Engineered Products
13.2 Biosafety and Risk Assessment
13.3 Ethical Implications of Synthetic Biology and Metabolic Engineering
14: Case Studies in Metabolic Engineering
14.1 Success Stories of Metabolic Engineering in Industry
14.2 Addressing bottlenecks and limitations in current metabolic engineering approaches
14.3 Opportunities for interdisciplinary collaboration and innovation
15: Future Perspectives and Emerging Trends
15.1 Advances in CRISPR and Genome Editing Technologies
15.2 Artificial Intelligence and Machine Learning in Metabolic Engineering
15.3 The Future of Synthetic Biology and Bioeconomy
- Edition: 1
- Latest edition
- Published: December 1, 2025
- Language: English
YA
Yogesh K. Ahlawat
Dr. Yogesh K. Ahlawat is currently an Associate Professor at Chandigarh University, Mohali, Punjab, India. He holds a PhD in the enhancement of biofuel production through plant cell wall biosynthesis, earned from Michigan Tech University in the United States. His research focuses on manipulating lignin biosynthesis in poplars to enhance biofuel yield. Dr. Ahlawat has developed hundreds of transgenic lines by overexpressing and silencing specific genes and transcription factors in Populus trichocarpa, the pioneering bioenergy tree, using tissue-specific promoters. With 13 years of extensive experience in functional genomics, postharvest genomics, and crop enhancement methodologies, Dr. Ahlawat has a commendable record of publishing impactful research. Dr. Ahlawat serves on the editorial boards of several prestigious journals such as the BMC series, Frontiers in Plant Science, Frontiers in Microbiology and Nutrition, and MDPI. His contributions have been recognized internationally through awards such as the Doctoral Finishing Fellowship, Best Graduate Teaching Award, and Best PhD Research Award. He holds several patents and has secured numerous national and international travel grants from esteemed organizations.
Affiliations and expertise
Associate Professor, Chandigarh University, Mohali, Punjab, IndiaPJ
Pawan K. Jaiwal
Dr. Pawan K. Jaiwal is an Emeritus Professor at the Centre for Biotechnology, Maharshi Dayanand University in Rohtak, India where he was formerly the Director and Dean of the Faculty of Life Sciences. He has nearly 32 years of post-graduate teaching experience in molecular biology, genetic engineering, and plant biotechnology, has guided 27 students for their PhDs, and has completed 12 major research projects funded by various national and international agencies. Dr. Jaiwal has contributed 16 books and authored 28 book chapters and 112 research papers in nationally and internationally reputed research journals. He is a member of several academic bodies and is on the editorial board of national and International journals. Dr. Jaiwal has worked and trained at the Institute of Plant Sciences, ETH, Zurich (Switzerland), the National Research Centre on Plant Biotechnology, New Delhi, and the University of Ghent, Belgium and has visited labs in Japan, China, and the United States for collaborative research.
Affiliations and expertise
Emeritus Professor and Former Dean of the Faculty of Life Sciences and the Director of the Centre for Biotechnology, Maharshi Dayanand University, Centre for Biotechnology, Rohtak, IndiaJY
Jaya Prakash Yadav
Prof. Jaya Prakash (J.P.) Yadav was serving as Vice Chancellor of Indira Gandhi University as well as Professor in the Department of Genetics at Maharshi Dayanand University, India. He has a total of 15 years of administrative experience and 30 years of teaching and research experience. Over the years, he has presented papers and taken on various organizational roles at national and international conferences and symposiums, including the National Conference of the Society of Cytology and Genetics, the National Symposium of Recent Advances in Biosciences and chairing sessions at the International Conference on Medicinal and Aromatic Plants. He has served in various editorial capacities, including the Editorial Board of esteemed journals like Plant Archives and Journal of Plant Sciences. Dr. Yadav has been recognized with awards and grants, including UGC fellowships and international travel grants and has served on numerous committees, including those for project sanctioning and evaluation.
Affiliations and expertise
Former Vice Chancellor, Indira Gandhi University, Meerpur, Rewari; Professor, Department of Genetics, Maharshi Dayanand University, Rohtak, IndiaNS
Nisha Sharma
Dr Nisha Sharma did her PhD in Microbiology from Dr YSPUHF, Nauni, Solan, Himachal Pradesh-India. She has been awarded “INSPIRE FELLOWSHIP” (JRF/SRF) by DST, New Delhi- India. She has worked as Research Associate for 3 years at YSPUHF. She has significantly contributed in the field of Agricultural, Industrial & Food Microbiology. She has great aptitude for research work as reflected by the paper published in peer reviewed journals, paper presented and acting as a “Rapporteus” in National and International conferences. She published about 50 research articles in reputed National and International Journals, 15 Book Chapters, 15 Popular articles, 1 Text Book of Agricultural Microbiology, 1 Laboratory Manual & 07 Patents.
Dr Nisha Sharma received many prestigious awards, viz. “Young Scientist Award” by Venus International Foundation, “International Best Researcher Award” by International American Council for Research and Development, (IACRD) United States of America and “Young Scientist of the Year” by National Environment Science Academy, New Delhi, India. She is member of many Professional Societies like NASI, NESA, JUST AGRICULTURE. She is a young researcher with considerable self-discipline and confidence.
Affiliations and expertise
Assistant Professor School of Life and Applied Sciences, Maya Devi University Dehradun, Uttarakhand, India