Nitric Oxide

1st Edition, Volume 96 - August 12, 2014
Editor: Gerald Litwack
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 0 2 5 4 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 0 4 3 9 - 5

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

Institutional subscription on ScienceDirect

Request a sales quote

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on nitric oxide.

Former Editors
Preface
Chapter One: Regulation of Nociceptive Transduction and Transmission by Nitric Oxide
- Abstract
- 1 Introduction
- 2 Role of NO in Nociceptive Transduction at the Periphery
- 3 Diverse Effects of NO on Ion Channels Expressed on Primary Sensory Neurons
- 4 Role of NO in Regulating Nociceptive Transmission at the Spinal Cord Level
- 5 NO Reduces Excitatory, But Potentiates Inhibitory, Synaptic Transmission in Spinal Cords
- 6 Conclusions and Future Directions
- Acknowledgments
Chapter Two: microRNA and Human Inducible Nitric Oxide Synthase
- Abstract
- 1 Introduction
- 2 Regulation of Human iNOS Gene
- 3 miRNAs Regulation
- 4 Conclusion
Chapter Three: Heart Mitochondrial Nitric Oxide Synthase: A Strategic Enzyme in the Regulation of Cellular Bioenergetics
- Abstract
- 1 Introduction
- 2 Heart Mitochondrial NO Production
- 3 Regulation of Heart mtNOS
- 4 Effects of NO on Heart Mitochondrial Function
- 5 Physiopathological Regulation of Heart mtNOS
- 6 Conclusions and Future Directions
- Acknowledgments
Chapter Four: Nitric Oxide Regulation of Adult Neurogenesis
- Abstract
- 1 Introduction
- 2 Adult Neurogenesis
- 3 Expression of NOS in Neurogenic Regions
- 4 Pharmacological Studies of NO on Adult Neurogenesis In Vivo
- 5 NOS Knockout Animals and Adult Neurogenesis
- 6 Neuropeptide Y and NO
- 7 The Dual Role of NO in Adult Neurogenesis
- 8 Concentration-Dependent Effects of NO
- 9 Conclusions
Chapter Five: Nitric Oxide in the Nervous System: Biochemical, Developmental, and Neurobiological Aspects
- Abstract
- 1 Introduction
- 2 NO Signaling Pathways
- 3 NO and Neuronal Viability
- 4 NO and Neurotransmitters Release
- 5 NO and Neuroplasticity
Chapter Six: Hippocampus and Nitric Oxide
- Abstract
- 1 Introduction
- 2 Profiles of NO in the CNS
- 3 NO and Hippocampal Plasticity
- 4 NO and the Related CNS Disorders
- 5 Conclusion
Chapter Seven: Nitric Oxide and Hypoxia Signaling
- Abstract
- 1 Introduction
- 2 Part 1: NO Biology in Normoxia, Hypoxia, and Anemia
- 3 Part 2: Effects of Hypoxia on NOSs
- 4 Summary
Chapter Eight: NO Binding to the Proapoptotic Cytochrome c–Cardiolipin Complex
- Abstract
- 1 Introduction
- 2 The cyt c–CL Complex
- 3 Ligand Binding to the cyt c/CL Complex
- 4 Insights into the Nature and Formation of the Proximal NO Complex in cyt c–CL
- 5 Conclusions
Chapter Nine: The Nitric Oxide-Mediated Regulation of Prostaglandin Signaling in Medicine
- Abstract
- 1 Introduction
- 2 NOS and NO Production
- 3 COX and Prostaglandin in Biology
- 4 The Role of Nitric Oxide in Prostaglandin Regulation
- 5 Perspective/conclusion
Chapter Ten: Nitric Oxide as a Mediator of Estrogen Effects in Osteocytes
- Abstract
- 1 Introduction
- 2 Bone-Protective Effects of Estrogen
- 3 Induction of NO Synthesis by Estrogen
- 4 NO/cGMP Signaling in Bone Cells
- 5 Bone-Anabolic Effects of NO in Humans—Lessons from Clinical Trials
- 6 Estrogen Promotion of Osteocyte Survival via the NO/cGMP/PKG Pathway
- Acknowledgment
Chapter Eleven: Insights into the Diverse Effects of Nitric Oxide on Tumor Biology
- Abstract
- 1 Introduction
- 2 Cellular Reactions of NO
- 3 Conclusion/Discussion
Chapter Twelve: Dual Effect of Interferon (IFNγ)-Induced Nitric Oxide on Tumorigenesis and Intracellular Bacteria
- Abstract
- 1 Introduction
- 2 Interferon γ
- 3 NOS2/NO
- 4 L-Arg Metabolism
- 5 NOS2/NO in Disease
- 6 IFNγ-Induced NO as a Mechanism to Inhibit Renal Cancer Growth
- 7 Conclusions and Future Directions
- Acknowledgments
Chapter Thirteen: Antiobesogenic Role of Endothelial Nitric Oxide Synthase
- Abstract
- 1 Introduction
- 2 eNOS is Important for Regulating Vascular and Metabolic Function
- 3 NO Bioavailability is Decreased in Obese and Diabetic States
- 4 Regulation of Obesity and Insulin Resistance by eNOS
- 5 Synopsis
- Acknowledgments
Chapter Fourteen: Nitric Oxide and Cerebrovascular Regulation
- Abstract
- 1 Introduction
- 2 Sources of NO in the Neurovascular Unit
- 3 Resting CBF
- 4 Autoregulation
- 5 Neurovascular Coupling (Fig. 14.1)
- 6 Conclusion
- Acknowledgments
Chapter Fifteen: Endothelial Nitric Oxide Synthase Gene Polymorphisms in Cardiovascular Disease
- Abstract
- 1 Introduction
- 2 Genetic Variants
- 3 eNOS Polymorphisms in CVD
- 4 eNOS Polymorphisms in Other Diseases
- 5 Conclusion
Chapter Sixteen: Role of Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension
- Abstract
- 1 Role of NO in Vasorelaxation and Proliferation in PH
- 2 Endothelial Nitric Oxide Synthase Expression and its Activity in Relationship to the Vasoreactivity
- 3 Physiological Role of NO in Pulmonary Hypertension
- 4 Use of NO in Patients with PH in Clinical Practice
- 5 Clinical Application of NO Inhalation in Patients with Pulmonary Hypertension
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Nitric Oxide

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Gerald Litwack