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NIH: An Account of Research in Its Laboratories and Clinics

  • 1st Edition - January 1, 1984
  • Latest edition
  • Editor: DeWitt Stetten
  • Language: English

NIH: An Account of Research in Its Laboratories and Clinics contains collected accounts of the Intramural Research Program, as they happened in the laboratories and clinics, in… Read more

Description

NIH: An Account of Research in Its Laboratories and Clinics contains collected accounts of the Intramural Research Program, as they happened in the laboratories and clinics, in various installations of the National Institutes of Health across the U.S.A. One paper discusses the etiology of schizophrenia which notes that, based on evidence and expanded adoption studies by Ketty, Rosenthal, and Wender, genetic factors actually contribute to the development of the disease. In developing countries, schizophrenia follows a more benign course. Some papers describe bacteriology, mycology, viral hepatitis, basic immunology, clinical immunology, and the development of enzymology. Researchers studying proteins elucidate on the synthesis and folding of protein chains, protein conformation and dynamics, the semisynthesis and protein function, as well as on sequence analysis and collagen research. Other papers describe the breaking of the genetic code, the progress made from the genetic code to beta thalassemia, to investigations of genetic diseases (such as galactosemia, gout, Lesch-Nyhan disease, mucopolysaccharide storage disease, and sickle cell disease). One paper notes the contribution of the intramural clinical research program of the National Cancer Institute to cancer therapy with emphasis in cancer chemotherapy. Professors in pharmacology, practitioners of general medicine, specialists or researchers dealing with microchemistry, toxicology, drug therapy, or oncology will find the collection valuable.

Table of contents


Contributors

Notes and Acknowledgments

Foreword


1 Prologue


2 The Early Days


3 Studies on the Etiology of Schizophrenia


4 Neurotransmitters and Neuropsychopharmacology


5 The Neurosciences—Basic and Clinical


6 Nutrition Research


7 Tissue Culture

I. The Tissue Culture Section, NCI

II. Studies in Cell Biology, NIAID

III. The Nervous System in Vitro


8 Bacteriology and Mycology


9 Viral Hepatitis


10 Immunology—Basic and Clinical

I. Introduction

II. Immunoglobulin Structure and Genetics

III. Genetic Control of Cellular Interactions and Specific Immune Response Genes

IV. Lymphokines

V. Clinical Immunology


11 Organic Chemistry in a Biomedical Research Organization


12 Development of Enzymology

I. Early Enzymological Research

II. Elucidation of the Pentose Phosphate Pathway

III. Recollections About Enzymology and Amino Acid Biochemistry at NCI


13 Studies on Proteins

I. The Synthesis and Folding of Protein Chains

II. Protein Conformation and Dynamics

III. Synthesis, Semisynthesis, and Protein Function

IV. Sequence Analysis

V. Collagen Research

VI. Muscle Research


14 A Revisionist View of the Breaking of the Genetic Code


15 From the Genetic Code to Beta Thalassemia


16 Genetic Diseases

I. Galactosemia: An Enzymological Approach

II. Gout and Lesch-Nyhan Disease

III. The Lipodystrophies

IV. Mucopolysaccharide Storage Diseases

V. Sickle Cell Disease


17 Viral Oncology


18 Virogenes to Oncogenes


19 SV40

I. The Virus and Poliomyelitis Vaccine

II. The Virus as a Model and Probe of Cellular Regulatory Processes


20 Studies on Slow Virus Diseases


21 Endocrinology


22 Spectroscopy and Chemical Physics


23 Computers in Biomedicai Research


24 Cardiac Surgery


25 Therapeutic Research in the National Cancer Institute


26 Epilogue

Index of Names

Product details

  • Edition: 1
  • Latest edition
  • Published: January 28, 1984
  • Language: English

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