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Nicotine Use in Mental Illness and Neurological Disorders
1st Edition - October 16, 2015
Editor: Mariella De Biasi
Hardback ISBN:9780128015834
9 7 8 - 0 - 1 2 - 8 0 1 5 8 3 - 4
eBook ISBN:9780128016268
9 7 8 - 0 - 1 2 - 8 0 1 6 2 6 - 8
Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art… Read more
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Nicotine Use in Mental Illness and Neurological Disorders
, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.
Provides a broad coverage of subject matter
Presents a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders
Ideal for researchers and practitioners, and those just entering the field
People working in basic neuroscience, neurology and psychiatry; medical doctors and care givers.
Preface
Part 1: Introductory chapter
Chapter One: Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine
Abstract
1 Introduction
2 Nicotinic Receptor Structure
3 Nicotinic Receptor Channel Gating
4 Cationic Permeability of the Nicotinic Receptor Pore
5 Nicotinic Receptor Response to Nicotine from Tobacco
6 Conclusion
Acknowledgment
Part 2: Schizophrenia
Chapter Two: The Role of Nicotine in Schizophrenia
Abstract
1 Introduction
2 Effects of Nicotine on Schizophrenia Endophenotypes and Symptom Domains
3 Nicotinic Receptor Genes in Schizophrenia
4 Development of Nicotinic Agents for the Treatment of Schizophrenia
5 Conclusions
Chapter Three: Neuronal α7 Nicotinic Receptors as a Target for the Treatment of Schizophrenia
Abstract
1 Introduction
2 The α7 nAChRs
3 The Heteromeric α7-Containing Receptors
4 Localization of the α7 Receptors
5 Allosteric Modulation
6 The α7 Receptors in Brain Circuits
7 α7 Receptors and Schizophrenia
8 α7 and NMDA Receptor Interactions in Schizophrenia
9 α7 Receptors as a Drug Target
10 Effects of α7-Selective Compounds on Behavior
11 Conclusions
Chapter Four: Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders
Abstract
1 Introduction
2 Known Mechanisms of Neuregulin–ErbB Signaling
3 NRG3: Relevance in Smoking Behavior and Co-morbid Disorders
4 ERBB4: Relevance in Smoking Behavior and Co-morbid Disorders
5 Summary
Chapter Five: Effective Cessation Strategies for Smokers with Schizophrenia
Abstract
1 Efficacy of Bupropion, as Monotherapy or in Combination with NRT
2 Efficacy of Varenicline
3 Duration of Treatment
4 Behavioral Treatment
5 Treatment Adherence
6 Safety Issues
7 Conclusion
Part 3: Mood disorders
Chapter Six: Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms
Abstract
1 Introduction
2 The NAc Reward Circuit in Mood Regulation
3 Transcriptional and Epigenetic Mechanisms in the NAc in Mood Regulation
4 Future Directions
Acknowledgment
Chapter Seven: Nicotine Addiction and Psychiatric Disorders
Abstract
1 Introduction
2 Nicotine's Effects on ADHD
3 Involvement of nAChRs in Anxiety and Anxiety Disorders
4 Effects of Nicotine Dependence, Withdrawal, and nAChR Regulation on Depression
5 Conclusion
Acknowledgment
Chapter Eight: The Role of Depression in the Uptake and Maintenance of Cigarette Smoking
Abstract
1 The Smoking and Depression Problem
2 Adolescent Smoking Uptake and Depression
3 Smoking Cessation and Depression
4 Targeting Positive Mood May Increase Smoking Cessation Treatment Effectiveness
5 Individual Differences in Cessation Outcome and Treatment Effectiveness
6 Conclusions
Part 4: Parkinson's disease
Chapter Nine: Nicotine and Nicotinic Receptor Drugs: Potential for Parkinson's Disease and Drug-Induced Movement Disorders
Abstract
1 Parkinson's Disease Overview
2 Neuroprotection and Parkinson's Disease
3 Nicotine and nAChR Drugs Do Not Improve Parkinsonian Motor Symptoms
4 Nicotine and nAChR Drugs Reduce LIDs
5 Nicotine and nAChR Drugs Reduce Antipsychotic-Induced Tardive Dyskinesias
6 Beneficial Role of Nicotine and nAChR Drugs in Cognition, Depression, and Other Neuropsychiatric Disorders
7 Concluding Remarks
Acknowledgment
Part 5: Alzheimer's disease
Chapter Ten: Nicotinic Cholinergic Mechanisms in Alzheimer's Disease
Abstract
1 Homomeric and Heteromeric α7-nAChRs
2 Alterations of α7-nAChR Expressions in AD Animal Models and AD Patients
3 Interaction of Amyloid Beta Peptides (Aβ) and α7-nAChRs
4 Coincident Roles of α7-nAChRs in Aβ Toxicity
5 Roles of α7-nAChRs in Neuronal Hyperexcitation in AD
6 Coincident Roles of α7-nAChRs in AD Pathogenesis