New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia, An Issue of Hematology/Oncology Clinics of North America

1st Edition, Volume 36-2 - March 30, 2022
Editors: Alexandra P. Wolanskyj-Spinner, Ronald S. Go
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 0 3 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 0 4 - 2

In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable e… Read more

New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia, An Issue of Hematology/Oncology Clinics of North America

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In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Red Cell Antigens and Antibodies
Key points
Introduction
Apparent red cell blood group antigen specificities
Specificities associated with cold-reactive autoantibodies
Transfusion considerations in autoimmune hemolytic anemia
Extended antigen typing by DNA methods
Autoimmune hemolytic anemia associated with transplantation and anticancer drug therapy
Transfusion considerations for autoimmune hemolytic anemia associated with passenger lymphocyte syndrome, allogenic hematopoietic stem cell transplantation, and checkpoint inhibitors
Summary
clinics care point
Conflict of interest
New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia: Traditional and Novel Tests
Key points
Background
Discussion
Standard testing
Summary
Clinics care points
DAT-Negative Autoimmune Hemolytic Anemia
Key points
Introduction
Background
Quantity of antibody on red blood cells
Low-affinity IgG
Other immunoglobulins
Complement
Methods used
Other test methods evaluated but not currently used in our laboratory
Discussion
Summary
Clinics care points
Autoimmune Hemolytic Anemia: Diagnosis and Differential Diagnosis
Key points
Introduction
Clinical manifestations
Incidence, prevalence, and differential diagnosis
Laboratory evaluation
Summary
Clinics care points
Updates in the Management of Warm Autoimmune Hemolytic Anemia
Key points
Introduction
Epidemiology
Pathophysiology
Clinical presentation
Treatment
Summary
Clinics care points
Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia
Key points
Introduction
Pathophysiology
Clinical features
Evaluation
Natural history of cold agglutinin disease
Treatment including emerging therapies for cold agglutinin hemolytic anemia
Complement inhibition in the management of cold agglutinin hemolytic anemia
Special considerations-transfusions and peri-operative management
Paroxysmal cold hemoglobinuria
Summary and conclusion
Clinics care points
FUNDING
Conflicts of interest
Complications of Autoimmune Hemolytic Anemia
Key points
Introduction
Complications related to active hemolysis
Complications related to hemolytic anemia management
Special considerations
Conclusion
Summary
Clinics care points
Immunotherapy-associated Autoimmune Hemolytic Anemia
Key points
Introduction
Description of ir-AIHA Epidemiology
Summary
Clinics care points
Disclosures
Adult Evans' Syndrome
Key points
Definition and epidemiology
Diagnosis of Evans syndrome
Primary or secondary Evans syndrome
Management of adult Evans syndrome
Summary

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New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia, An Issue of Hematology/Oncology Clinics of North America

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Alexandra P. Wolanskyj-Spinner

Ronald S. Go