New Approaches Towards Novel Antibacterial Agents
- 1st Edition, Volume 60 - October 26, 2023
- Editor: Christian Ducho
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 7 1 1 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 7 1 2 - 9
New Approaches Towards Novel Antibacterial Agents, Volume 60 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presen… Read more
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Request a sales quoteNew Approaches Towards Novel Antibacterial Agents, Volume 60 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
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- Presents the latest release in Annual Reports in Medicinal Chemistry series
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Undergraduates, graduates, academics, and researchers in the field of medicinal chemistry
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One The challenges and opportunities of developing small molecule inhibitors of MraY
- Abstract
- 1 Introduction of phospho-MurNAc-pentapeptide translocase (MraY)
- 2 Targeting MraY: A promising strategy for combating bacterial infections
- 3 Structures and insights on MraY inhibition with nucleoside natural products
- 4 Non-nucleoside inhibitors of MraY––Small molecules to peptidomimetics
- 5 Non-traditional inhibitors of MraY
- 6 Perspective: Is a clinically viable MraY-targeted antibacterial possible in the near future?
- Acknowledgments
- References
- Chapter Two Nucleoside-derived inhibitors of MraY: Medicinal chemistry with natural products
- Abstract
- 1 Introduction
- 2 Muraymycins
- 3 Caprazamycins and related compounds
- 4 Mureidomycins and related compounds
- 5 Capuramycins
- 6 Tunicamycins
- 7 Conclusion
- References
- Chapter Three Inhibitors of the bacterial enzyme MurA as potential novel antibiotics
- Abstract
- 1 Introduction
- 2 Covalent inhibitors of MurA
- 3 Non-covalent inhibitors of MurA
- 4 Concluding remarks
- References
- Chapter Four Bacterial metalloproteases as promising drug targets for antivirulence agents
- Abstract
- 1 Antibiotic resistance
- 2 Proposed strategies to tackle resistance development
- 3 Bacterial metalloproteases as virulence factors
- 4 Substrates of bacterial metalloproteases
- 5 Antivirulence agent development between concern and hope
- References
- Chapter Five Quo vadis quorum sensing? Advances in disrupting the Pseudomonas quinolone signal (PQS)
- Abstract
- 1 Introduction
- 2 The Pseudomonas quinolone signal (PQS) as a target for drug discovery
- 3 Approach (A)—Inhibition of the signal molecule biosynthesis cascade PqsABCDE
- 4 Approach (B)—Inhibition of the signal molecule receptor PqsR
- 5 Conclusion
- References
- No. of pages: 310
- Language: English
- Edition: 1
- Volume: 60
- Published: October 26, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443137112
- eBook ISBN: 9780443137129
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Christian Ducho
Christian Ducho currently works in the Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University. Christian does research in Pharmaceutical and Medicinal Chemistry, Chemical Biology and Organic Chemistry. Their current main projects are antibiotics and modified oligonucleotides.
Affiliations and expertise
Saarland University, Department of Pharmacy, Pharmaceutical and Medicinal ChemistryRead New Approaches Towards Novel Antibacterial Agents on ScienceDirect