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Neurotoxicity of Microplastics and Nanoplastics

  • 1st Edition, Volume 17 - June 1, 2027
  • Latest edition
  • Editors: Lucio G. Costa, Michael Aschner
  • Language: English

Neurotoxicity of Microplastics and Nanoplastics provides state-of-the-art reviews on topics in neurotoxicology. The book series addresses molecular and cellular mechanisms, experi… Read more

Description

Neurotoxicity of Microplastics and Nanoplastics provides state-of-the-art reviews on topics in neurotoxicology. The book series addresses molecular and cellular mechanisms, experimental models, environmental and occupational toxicants, and the effects of neurotoxins on neurological disease. The series emphasizes critical synthesis of current knowledge while highlighting novel mechanistic insights.

Key features

  • Mechanistic insights
  • Translational relevance
  • Methodological advances

Readership

Undergraduates, graduates, academics, and researchers in the field of Neurotoxicity of Microplastics and Nanoplastics research

Table of contents

1. Neurotoxicity of microplastics:From cellular targets to systemic consequences
Anju Sharma, Deepshikha Shekhawat, Manjyot Kaur and Kirti Sharma

2. Neurotoxicity of Micro- and Nanoplastics: Insights from the model organism zebrafish (Danio rerio).
Dércia Santos and Ana Luzio

3. The airborne trouble: nanoplastics inhalation and neurotoxicity
Stefano Farioli Vecchioli

4. Harnessing Drosophila melanogaster to Unravel Micro/Nanoplastics-Induced Neurotoxicity and Protective Mechanisms: A New Frontier in Environmental Neurotoxicology
Amos Olalekan Abolaji and Michael Aschner

5. The impact of micro-/nanoplastics on brain development, structure, and function: a review of data from mouse models
Lindsay Cahill

6. Neurobehavioral phenotypes and neurochemical responses associated with microplastics exposure in zebrafish
Isaac Adegboyega Adedara

7. Neurotoxicity of micro-nanoplastics in Caenorhabditis elegans models: behavioral and genetic insights
Isaac Adegboyega Adedara

8. TBD
Elaine Faustman

9. Synaptic health in brain disorders: Impact of nanoplastic exposure
Omamuyovwi M. Ijomone

10. Developmental Exposure to Microplastics: A Hidden Threat to Early Brain Maturation
Omamuyovwi M. Ijomone

11. The mechanisms and targets of micro/nanoplastics-induced neurotoxicity by network toxicology and Molecular docking
Lu Rhongzu

12. Comparative Approaches to Micro- and Nanoplastics Toxicity with a Focus on Reproductive and Neurotoxic Outcomes
Lidwina Bertrand, Veronica Shoijet, María Fernanda Hornos Carneiro, Patricia Antonia Lucero and Miriam Beatríz Virgolini

13. Microbiome and environment interactions in neurotoxicity
Julia Yue Cui

14. Current Understanding of Micro- and Nanoplastics Body Burden: Advances and Analytical Challenges
Junli Xu

15. Molecular mechanisms of nanoplastic-induced neurotoxicity: focus on the oxidative stress and mitochondrial dysfunction.
Marta Sidoryk-Węgrzynowicz

Product details

  • Edition: 1
  • Latest edition
  • Volume: 17
  • Published: June 1, 2027
  • Language: English

About the editors

Lucio G. Costa

Serial Editor
Dr. Costa is Professor Emeritus of Toxicology in the Department of Environmental and Occupational Health Sciences at the University of Washington in Seattle. Before joining the University of Washington in 1983 he received a doctorate in Pharmacology from the University of Milano and was a postdoctoral fellow at the University of Texas at Houston. Over the years he served as the Director of the University of Washington Toxicology Program, Director of the Neurotoxicology Research Core of the NIEHS Center in Ecogenetics and Environmental Health, and a Core Faculty of the Environmental and Occupational Epidemiology Training Program and the Environmental Pathology/Toxicology Training Program at the University of Washington. He has also held professorial positions at various Universities in Italy (Parma, Bari, Roma, Pavia, Milano). He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various awards for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. Dr. Costa has been a member of several panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has been teaching classes in pharmacology, toxicology, and neurotoxicology for over 35 years, and has kept an active research program in neurotoxicology, with >500 publications, books and book chapters. The primary focus of his research relates to the toxicology and neurotoxicology of pesticides, environmental contaminants, alcohol, air pollution, and on various aspects of gene-environment interactions in relationship to neurotoxicity and neurodegeneration.
Affiliations and expertise
Professor of Toxicology, University of Washington, Seattle, WA, USA

Michael Aschner

Serial Editor
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control, FDA, National Academy of Sciences, US Department of Defense), and was a member and chair of the Neurotoxicology and Alcohol study section (NIH). He served as the President of the Society of Toxicology and has previously served as the President of the Academy of Toxicological Sciences and the International Neurotoxicology Association. He has authored (co-authored) >1,100 peer reviewed manuscripts and 110 book chapters, his h-index is 124, and he is a recipient of Honorary Doctorate from the University of Cordoba in Argentina. Research in his lab focuses on: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of methylmercury (MeHg) uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. His studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and expertise
Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA