Skip to main content
Elsevier

Neurotoxicity of Metals: Old Issues and New Developments

  • 1st Edition, Volume 5 - April 17, 2021
  • Latest edition
  • Editors: Michael Aschner, Lucio G. Costa
  • Language: English

The volume discusses novel issues associated with the neurotoxicity of select me… Read more

Description

The volume discusses novel issues associated with the neurotoxicity of select metals

Key features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Advances in Neurotoxicology series
  • Updated release includes the latest information on the mechanisms associated with neurodegeneration, neurodevelopmental effects, and brain accumulation of metals
  • New approaches for the study of metal neurotoxicity

Readership

Faculty, students, risk assessors, federal employees, industry scientists

Table of contents

1. Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

Anatoly V. Skalny, Michael Aschner, Yueming Jiang , Yordanka G. Gluhcheva, Yousef Tizabi, Ryszard Lobinski and Alexey A. Tinkov

2. Arsenic-mediated developmental neurotoxicity: Recent advances in understanding the adverse outcomes and underlying mechanisms

Stefan Masjosthusmann, Julia Tigges, Ellen Fritsche and Katharina Koch

3. Cadmium neurotoxicity: From its analytical aspects to neuronal impairment

Jamile Fabbrin Gonçalves, Valderi Luiz Dressler, Charles Elias Assmann, Vera Maria Melchiors Morsch and Maria Rosa Chitolina Schetinger

4. Neurotoxicity of copper and copper nanoparticles

Arundhati Joshi, Kathrin Farber and Ivo F. Scheiber

5. Molecular mechanisms of lead neurotoxicity

Miriam B. Virgolini and Michael Aschner

6. Neurotoxicity mechanisms of manganese in the central nervous system

Edward Pajarillo, Ivan Nyarko-Danquah, Getinet Adinew, Asha Rizor, Michael Aschner and Eunsook Lee

7. Neurotoxicity of mercury: An old issue with contemporary significance

Vasco Branco, Michael Aschner and Cristina Carvalho

8. Neurotoxicity of nickel

Omamuyovwi M. Ijomone

9. Neurotoxicity of thallium: Old issues and new developments

Laura Osorio-Rico, Abel Santamaría, Syed F. Ali and Sonia Galván-Arzate

10. Neurotoxicity of vanadium

FA Olaolorun, FE Olopade, IL Usende, AD Lijoka, AD Ladagu and JO Olopade

　

11. Neurotoxicity of metal mixtures

Lopes de Andrade, Vanda, Marreilha dos Santos, Ana Paula and Aschner, Michael

Product details

  • Edition: 1
  • Latest edition
  • Volume: 5
  • Published: April 17, 2021
  • Language: English

About the editors

Michael Aschner

Serial Editor
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control, FDA, National Academy of Sciences, US Department of Defense), and was a member and chair of the Neurotoxicology and Alcohol study section (NIH). He served as the President of the Society of Toxicology and has previously served as the President of the Academy of Toxicological Sciences and the International Neurotoxicology Association. He has authored (co-authored) >1,100 peer reviewed manuscripts and 110 book chapters, his h-index is 124, and he is a recipient of Honorary Doctorate from the University of Cordoba in Argentina. Research in his lab focuses on: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of methylmercury (MeHg) uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. His studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and expertise
Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

Lucio G. Costa

Serial Editor
Dr. Costa is Professor Emeritus of Toxicology in the Department of Environmental and Occupational Health Sciences at the University of Washington in Seattle. Before joining the University of Washington in 1983 he received a doctorate in Pharmacology from the University of Milano and was a postdoctoral fellow at the University of Texas at Houston. Over the years he served as the Director of the University of Washington Toxicology Program, Director of the Neurotoxicology Research Core of the NIEHS Center in Ecogenetics and Environmental Health, and a Core Faculty of the Environmental and Occupational Epidemiology Training Program and the Environmental Pathology/Toxicology Training Program at the University of Washington. He has also held professorial positions at various Universities in Italy (Parma, Bari, Roma, Pavia, Milano). He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various awards for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. Dr. Costa has been a member of several panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has been teaching classes in pharmacology, toxicology, and neurotoxicology for over 35 years, and has kept an active research program in neurotoxicology, with >500 publications, books and book chapters. The primary focus of his research relates to the toxicology and neurotoxicology of pesticides, environmental contaminants, alcohol, air pollution, and on various aspects of gene-environment interactions in relationship to neurotoxicity and neurodegeneration.
Affiliations and expertise
Professor of Toxicology, University of Washington, Seattle, WA, USA

View book on ScienceDirect

Read Neurotoxicity of Metals: Old Issues and New Developments on ScienceDirect