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Neurotoxicity of Halogenated Organic Compounds
- 1st Edition, Volume 10 - October 25, 2023
- Editors: Lucio G. Costa, Michael Aschner, Prasada Rao S. Kodavanti
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 3 4 0 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 3 4 1 - 1
Neurotoxicity of Halogenated Organic Compounds, Volume 10 covers three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legac… Read more
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Request a sales quoteNeurotoxicity of Halogenated Organic Compounds, Volume 10 covers three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legacy and emerging contaminants, providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Specific chapters covered in this release include Perspective on Halogenated Organic Compounds, The Neurotoxicity of Polychlorinated Biphenyls (PCBs), Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs), Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR reality, Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs), and much more.
Other chapters cover Neuroendocrine Effects of Brominated Flame Retardants (BFRs), Focused on Polybrominated Diphenyl Ethers (PBDEs), Neurochemical Effects of Halogenated Organic Compounds: Possible Mode(s) of action and Structure-Activity Relationships, The Neurotoxic Effects of Perfluoroalkyl Substances (PFAS) in Animal Models and Human Cohorts, Neurochemical Mechanisms of Perfluoroalkyl Substances (PFAS) Neurotoxic Action, and Future Directions and Regulatory aspects of Halogenated Organic Compounds.
- Presents the latest on the Neurotoxicity of Halogenated Organic Compounds: Epidemiological, Behavioral and other effects
- Covers Neurochemical and Neuroendocrine effects of Halogenated Organic Compounds
- Provides Regulatory aspects of Halogenated Organic Compounds
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Perspective on halogenated organic compounds
- Abstract
- 1 Introduction
- 2 Background and classes of HOCs
- 3 Summary and conclusions
- Acknowledgments
- References
- Further reading
- Chapter Two: The neurotoxicity of polychlorinated biphenyls (PCBs)
- Abstract
- 1 Introduction
- 2 Human studies
- 3 Experimental animal studies
- 4 Conclusions
- Acknowledgments
- References
- Chapter Three: Neuroendocrine effects of polychlorinated biphenyls (PCBs)
- Abstract
- 1 Introduction
- 2 Overview of the hypothalamic–pituitary–gonadal and hypothalamic–pituitary–thyroid neuroendocrine systems
- 3 PCBs as environmental neuroendocrine disruptors
- 4 PCBs effects on the hypothalamic–pituitary-gonadal axis
- 5 PCBs and the hypothalamic–pituitary-thyroid axis
- 6 Neuroendocrine effects of PCBs on the hypothalamo-neurohypophysial system (HNS)
- 7 Inter- and transgenerational effects of PCBs on neuroendocrine systems
- 8 The future of toxicity testing for endocrine disruption: The ATHENA project on thyroid hormone system disruptors
- Acknowledgments
- References
- Chapter Four: Ryanodine receptor-dependent mechanisms of PCB developmental neurotoxicity
- Abstract
- 1 Introduction
- 2 PCB–RyR interactions
- 3 RyR-dependent cellular effects of PCBs
- 4 Evidence that RyR sensitization mediates the behavioral effects of PCBs
- 5 Implications of RyR-dependent mechanisms of PCB developmental neurotoxicity
- 6 Conclusions
- Acknowledgments
- References
- Chapter Five: The microbiome/microbiota and the neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
- Abstract
- 1 PBDEs: Uses, contamination, and body burden
- 2 Kinetics of PBDEs and structure–activity relationship considerations
- 3 PBDEs: Adverse health effects
- 4 Neurotoxicity of PBDEs
- 5 Possible mechanisms of PBDE developmental neurotoxicity
- 6 An overview of the microbiome and microbiota
- 7 PBDEs and the microbiota
- 8 Effects of PBDEs on the microbiota and its association with neurotoxicity
- 9 Conclusions and future avenues for research
- Acknowledgments
- References
- Chapter Six: Neuroendocrine effects of brominated flame retardants, focused on polybrominated diphenyl ethers
- Abstract
- 1 Introduction
- 2 General characteristics of the main BFRs
- 3 Overview of the neuroendocrine system
- 4 Neuroendocrine disruption by BFRs
- 5 Neuroendocrine effects of PBDEs
- 6 Neuroendocrine effects of PBBs
- 7 Neuroendocrine effects of HBCD
- 8 Neuroendocrine effects of TBBPA
- 9 Neuroendocrine effects of NBFRs
- 10 General conclusions
- Acknowledgments
- References
- Chapter Seven: Neurochemical effects of halogenated organic compounds: Possible adverse outcome pathways and structure–activity relationships
- Abstract
- 1 Introduction
- 2 Human (epidemiological studies) evidence of neurotoxicity by HOCs (PCBs and PBDEs)
- 3 Evidence of neurotoxicity in animals by HOCs (PCBs and PBDEs)
- 4 Neurotoxicity of HOCs (PCBs and PBDEs)—Potential adverse outcome pathways
- 5 Structure–activity relationships among HOCs (PCBs and PBDEs) on intracellular signaling events (PKC translocation and calcium buffering)
- 6 Summary and future directions
- Acknowledgments
- References
- Chapter Eight: Neurotoxicity of poly- and perfluoroalkyl substances (PFAS): Epidemiological and rodent studies of behavioral outcomes
- Abstract
- 1 Introduction
- 2 PFAS and epidemiological studies
- 3 PFAS and rodent studies
- 4 Conclusions
- Acknowledgments
- References
- Chapter Nine: Neurochemical mechanisms of perfluoroalkyl substances (PFAS) neurotoxic action
- Abstract
- 1 PFAS absorption and deposition in the brain
- 2 PFAS effects on neurotransmitters
- 3 PFAS and neuronal calcium signaling
- 4 Functional consequences of PFAS exposure and disease risk
- 5 Conclusions
- References
- Chapter Ten: Risk assessment, risk management, and regulation of halogenated organic chemicals: Current practice and future directions
- Abstract
- 1 Overview of risk assessment
- 2 Testing industrial and environmental chemicals for neurotoxicity
- 3 Analytical challenges and advanced methodologies for characterizing HOCs
- 4 Current U.S. federal and state legislation for regulating HOCs
- 5 Future directions for improving risk assessment and risk management of HOCs
- 6 Summary
- Acknowledgments
- References
- No. of pages: 462
- Language: English
- Edition: 1
- Volume: 10
- Published: October 25, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443133404
- eBook ISBN: 9780443133411
LC
Lucio G. Costa
MA
Michael Aschner
PK