
Neurotoxicity of Drugs of Abuse
- 1st Edition, Volume 8 - September 15, 2022
- Imprint: Academic Press
- Editors: Lucio G. Costa, Michael Aschner, William Slikker Jr.
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 5 8 5 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 5 8 6 - 1
Neurotoxicity of Drugs of Abuse, Volume Eight provides carefully crafted reviews on the disruptive impact of drugs of abuse on the central nervous system. The neurotoxi… Read more

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Request a sales quoteNeurotoxicity of Drugs of Abuse, Volume Eight provides carefully crafted reviews on the disruptive impact of drugs of abuse on the central nervous system. The neurotoxicity potential of several agents including marijuana, fentanyl, and ketamine are carefully reviewed, and their short-term and chronic effects are categorized. Pharmacokinetic profiles as well as mechanisms of action for these and other drugs of abuse such as alcohol and nicotine are also evaluated. The implications of short and long-term abuse for agents such as PCP are also characterized. The reader will come away with a fuller understanding of the adverse effects of drugs of abuse on the nervous system.
- Describes in detail the characteristics of drugs of abuse that produce neurotoxicity
- Summarizes both the short and long-term adverse effects of drugs of abuse on the nervous system
- Describes potential mechanisms of action of centrally acting drugs of abuse
Basic researchers, clinicians, epidemiologists, regulators, drug developers, chemists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- References
- Chapter One: Cannabinoids
- Abstract
- 1: Introduction
- 2: The endocannabinoid system (ECS)
- 3: Endocannabinoid system influence on the generation of neural cells
- 4: Biological basis for potential adverse effects
- 5: Conclusions
- References
- Chapter Two: Converging mechanisms in ethanol neurotoxicity
- Abstract
- 1: Introduction
- 2: Ethanol metabolism
- 3: Neurotransmission and intracellular pathways
- 4: Oxidative stress
- 5: Animal models of ethanol-induced neurotoxicity
- 6: Conclusions and future considerations
- Acknowledgments
- References
- Chapter Three: Neurotoxicology of nicotine and tobacco
- Abstract
- 1: Introduction
- 2: Prenatal and neonatal development
- 3: Adolescence
- 4: Adulthood
- 5: Aging
- 6: Future directions
- 7: Summary and conclusions
- Acknowledgment
- References
- Chapter Four: The neurotoxic potential of opioids including fentanyl and fentanyl analogs
- Abstract
- 1: Introduction
- 2: Neurotoxicology of fentanyl and related compounds
- 3: Conclusions
- References
- Chapter Five: Phencyclidine (PCP)-induced neurotoxicity and behavioral deficits
- Abstract
- 1: Introduction
- 2: Experimental evidence for PCP-induced neurotoxicity
- 3: Potential basic mechanisms underlying PCP-induced neurotoxicity
- 4: Prevention/improvement of PCP-induced neurotoxicity
- 5: Summary
- Acknowledgments
- References
- Further reading
- Chapter Six: The mysterious beauty of ketamine: Benefits and risks
- Abstract
- 1: Introduction
- 2: Between PCP and ketamine
- 3: Ketamine and apoptosis
- 4: Ketamine-induced psychosis
- 5: Ketamine and schizophrenic symptoms
- 6: Ketamine and cognitive functioning
- 7: Conclusion
- References
- Edition: 1
- Volume: 8
- Published: September 15, 2022
- No. of pages (Hardback): 194
- No. of pages (eBook): 194
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323915854
- eBook ISBN: 9780323915861
LC
Lucio G. Costa
MA
Michael Aschner
WS