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Neuroscience of Alcohol

Mechanisms and Treatment

  • 1st Edition - March 19, 2019
  • Latest edition
  • Editor: Victor R. Preedy
  • Language: English

Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol a… Read more

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Description

Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse.

Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance.

Key features

  • Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function
  • Discusses alcohol use as a component of dual-use and poly addictions
  • Outlines numerous screening and treatment strategies for alcohol misuse
  • Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

Readership

Advanced students and researchers in the areas of neuroscience, drug abuse, addiction, and pharmacology

Table of contents

PART I: INTRODUCTORY CHAPTERS

1. Becoming a "Successful" Drinker and a Graduate: A Sociological Perspective on Alcohol Consumption by University Students
CLAIRE TANNER, JO LINDSAY, ROSE LEONTINI, SIAN SUPSKI, JULIE HEPWORTH, TONI SCHOFIELD AND JOHN GERMOV

2. Molecular Genetics Meets Sociology: Birth Cohort Effects on Alcohol Use and Relationship With Candidate Genes
JAANUS HARRO AND MARILIIS VAHT

3. Alcohol and Women: Unique Risks, Effects, and Implications for Clinical Practice
LINDA RICHTER

4. ADH and ALDH Polymorphisms in Alcoholism and Alcohol Misuse/Dependence
MEERA VASWANI

5. Acetaldehyde in the Brain After Ethanol Exposure: Research Progress and Challenges
MOSTOFA JAMAL, ASUKA ITO, NAOKO TANAKA, AYAKA TAKAKURA, KIYOSHI AMENO AND HIROSHI KINOSHITA

6. Consequences of Ethanol Exposure on Neurodevelopment
MANUEL ALVES DOS SANTOS JÚNIOR, GERMANA SILVA VASCONCELOS, CAREN NÁDIA SOARES DE SOUSA, DANIELLE MACEDO AND SILVÂNIA MARIA MENDES VASCONCELOS

7. Animal Models of Binge Drinking: Behavior and Clinical Relevance
JÉRÔME JEANBLANC, BENJAMIN ROLLAND, PIERRE MAURAGE, FABIEN GIERSKI AND MICKAEL NAASSILA

PART II: NEUROBIOLOGY

8. Prenatal Alcohol Exposure: Developmental Abnormalities in the Brain
DAVID J. ROHAC, CHARLES W. ABBOTT AND KELLY J. HUFFMAN

9. Connecting Prenatal Alcohol, Its Metabolite Acetaldehyde, and the Fetal Brain
M. GABRIELA CHOTRO, MIRARI GAZTAÑAGA AND ASIER ANGULO-ALCALDE

10. Fetal Alcohol Exposure and the Central Nervous Control of Breathing
O. PIERREFICHE

11. Synaptic Plasticity in the Hippocampus and Alcohol Exposure During Brain Development
O. PIERREFICHE

12. Ethanol and Cortical Spreading Depression: The Protective Role of α-Tocopherol
RUBEM CARLOS ARAÚJO GUEDES, RANILSON DE SOUZA BEZERRA AND RICARDO ABADIE-GUEDES

13. Brain Electrophysiological Signatures in Human Alcoholism and Risk
CHELLA KAMARAJAN

14. Alcohol and Hippocampal Epileptiform Activity
VICTOR DIEGO CUPERTINO COSTA, LUIZ EDUARDO CANTON SANTOS, ANTÔNIO MÁRCIO RODRIGUES, FÚLVIO ALEXANDRE SCORZA, CARLA ALESSANDRA SCORZA, ARTHUR GUERRA DE ANDRADE AND ANTÔNIO-CARLOS GUIMARÃES DE ALMEIDA

15. Effects of Alcohol on the Corpus Callosum
EMILIO GONZÁLEZ-REIMERS, CANDELARIA MARTÍN-GONZÁLEZ, LUCÍA ROMERO-ACEVEDO, GERALDINE QUINTERO-PLATT, EMILIO GONZALEZ-ARNAY AND FRANCISCO SANTOLARIA-FERNÁNDEZ

16. The Role of the Lateral Habenula Circuitries in Alcohol Use Disorders
NIMISHA SHIWALKAR, WANHONG ZUO, ALEX BEKKER AND JIANG-HONG YE

17. Ventral Pallidum and Alcohol Addiction
ASHEETA A. PRASAD AND GAVAN P. MCNALLY

18. The Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in the Rewarding Effects of Ethanol
MARIO RIVERA-MEZA

19. Neuroimmune Aspects of Alcoholism and Affective Comorbidity
SUDAN P. NEUPANE

20. Social Drinking and Motor Inhibition: Evidences From FMRI Go/Nogo Tasks fMRI Studies on Alcohol Effect on Inhibition
ELISA SCHRÖDER AND SALVATORE CAMPANELLA

21. Myelopathy and Neuropathy Associated With Alcoholism
HARUKI KOIKE

22. Alcohol Consumption and the Risk of Amyotrophic Lateral Sclerosis
FABRIZIO D’OVIDIO, UMBERTO MANERA AND ADRIANO CHIÒ

23. Alcohol and Pain Interactions
HENRY L. BLANTON, SUSAN E. BERGESON, DANIEL J. MORGAN AND JOSÉE GUINDON

24. Neurobiological Aspects of Ethanol-Derived Salsolinol
ELIO ACQUAS, SIMONA SCHEGGI AND ALESSANDRA T. PEANA

25. Brain Networks in Active Alcoholism and Enduring Recovery: Functional Magnetic Resonance Imaging, Electrophysiological Studies, and Implications for Targeted Treatments
GEORGE FEIN AND VALERIE CARDENAS

26. Central Role of Amygdala and Hypothalamus Neural Circuits in Alcohol Withdrawal Symptom
KATHERYN WININGER, VICTOR KARPYAK, SEUNGWOO KANG AND DOO-SUP CHOI 

PART III: PSYCHOLOGY, BEHAVIOR, AND ADDICTION

27. Neural Reward Processing in Human Alcoholism and Risk: A Focus on Event-Related Potentials, Oscillations, and Neuroimaging
CHELLA KAMARAJAN

28. Occipito-Temporal Sensitivity and Emotional Faces in Alcohol Use Disorder
SARANYA SUNDARAM, EVA M. MÜLLER-OEHRING AND TILMAN SCHULTE

29. Alcohol and Violence in Psychopathy and Antisocial Personality Disorder: Neural Mechanisms
NATHAN J. KOLLA AND CHRISTINE C. WANG

30. Language Lateralization in Fetal Alcohol Spectrum Disorders
ANNUKKA K. LINDELL

31. Deprivation in Rewards and Alcohol Misuse
ASHLEY A. DENNHARDT, SAMUEL F. ACUFF, ALI M. YURASEK AND JAMES G. MURPHY

32. Alcohol (Mis)Use in Individuals With Mild to Borderline Intellectual Disability
NEOMI VAN DUIJVENBODE, JOANNE E.L. VANDERNAGEL AND ROBERT DIDDEN

33. Sex, Stress, and Neuropeptides Interact to Influence Alcohol Consumption
TODD B. NENTWIG AND JUDITH E. GRISEL

34. Maternal Separation Stress in Fetal Alcohol Spectrum Disorders: A Case of Double Whammy
SHIVA M. SINGH AND BONNIE ALBERRY

35. Impulsivity and Binge Drinking: A Neurocognitive Perspective
PIERRE MAURAGE, SÉVERINE LANNOY, MICKAEL NAASSILA, BENJAMIN ROLLAND AND JOËL BILLIEUX

36. Acetaldehyde and Motivation
ANNA BRANCATO AND CARLA CANNIZZARO

37. Age-Related Differences in the Appetitive and Aversive Motivational Effects of Alcohol
RICARDO MARCOS PAUTASSI

38. Alcoholism in Bipolar Disorders: An Overview of Epidemiology, Common Pathogenetic Pathways, Course of Disease, and Implications for Treatment
MARCO DI NICOLA, LORENZO MOCCIA, VITTORIA RACHELE FERRI, ISABELLA PANACCIONE AND LUIGI JANIRI

39. Socio-Emotional Deficits in Severe Alcohol Use Disorders
PIERRE MAURAGE, BENJAMIN ROLLAND AND FABIEN D’HONDT

40. Relapse Risks in Patients With Alcohol Use Disorders
AYAKO YAMASHITA AND SHIN-ICHI YOSHIOKA

41. The Neurocognitive Effects of Alcohol Hangover: Patterns of Impairment/Nonimpairment Within the Neurocognitive Domains of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition
L. DARREN KRUISSELBRINK

PART IV: PHARMACOLOGY, NEUROACTIVES, MOLECULAR, AND CELLULAR BIOLOGY

42. Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk
PATRIZIA PORCU, ALESSANDRA CONCAS AND A. LESLIE MORROW

43. Alcohol’s Effects on Extracellular Striatal Dopamine
ASHLEY A. VENA AND RUEBEN GONZALES

44. Nicotinic Cholinergic Mechanisms in Alcohol Abuse and Dependence
SHAFIQUR RAHMAN AND RICHARD L. BELL

45. Opioid System and Alcohol Consumption
JORGE JUÁREZ AND LUZ M. MOLINA-MARTÍNEZ

46. The Enkephalinergic System and Ethanol Effects
MILAGROS MÉNDEZ, KARLA HERNÁNDEZ-FONSECA AND PAULA ABATE

47. Alcohol and Central Glutamate Activity: What Goes Up Must Come Down?
RICHARD L. BELL, YOUSSEF SARI AND SHAFIQUR RAHMAN

48. Ethanol and Hippocampal Gene Expression: Linking in Ethanol Metabolism, Neurodegeneration, and Resistance to Oxidative Stress
MARIO DÍAZ, VERÓNICA CASAÑAS-SÁNCHEZ, DAVID QUINTO- ALEMANY AND JOSÉ A. PÉREZ

49. Stress, Alcohol, and Hippocampal Genes
JESSICA A. BAKER, LU LU AND KRISTIN M. HAMRE

50. Genes and Alcoholism: Taste, Addiction, and Metabolism
ARTURO PANDURO, INGRID RIVERA-IÑIGUEZ, OMAR RAMOS-LOPEZ AND SONIA ROMAN

51. Ethanol Exposure During Development, and Brain Oxidative Stress
JOANA GIL-MOHAPEL, CLAUDIA D. BIANCO, PATRICIA A. CESCONETTO, ARIANE ZAMONER AND PATRICIA S. BROCARDO

52. Alcohol-Induced Oxidative Stress in the Brain: Suggested Mechanisms, Associated Disorders, and Therapeutic Strategies
MIROSLAVA GEORGIEVA VARADINOVA, MARIA LOZANOVA VALCHEVA-TRAYKOVA AND NADKA IVANOVA BOYADJIEVA

53. Lead Exposure and Ethanol Intake: Oxidative Stress as a Converging Mechanism of Action
MIRIAM B. VIRGOLINI, MARA S. MATTALLONI, ROMINA DEZA-PONZIO, PAULA A. ALBRECHT AND LILIANA M. CANCELA

PART V: ALCOHOL AND OTHER ADDICTIONS

54. Alcohol and Gambling Addiction
MARKO MARTINAC, DALIBOR KARLOVIć AND DRAGAN BABIć

55. Neuroscience of Alcohol and Crack Cocaine Use: Metabolism, Effects and Symptomatology
ANTONIO GOMES DE CASTRO-NETO, ROSSANA CARLA RAMEH-DE-ALBUQUERQUE, POLLYANNA FAUSTA PIMENTEL DE MEDEIROS AND ROBERTA UCHÔA

56. The Impact of Ethanol Plus Caffeine Exposure on Cognitive, Emotional, and Motivational Effects Related to Social Functioning
MERCÈ CORREA, LAURA LÓPEZ-CRUZ, SIMONA PORRU AND JOHN D. SALAMONE

PART VI: BIOMARKERS AND SCREENING

57. Biomarkers of Alcohol Misuse
AURELIE DE VOS, RANI DE TROYER AND CHRISTOPHE STOVE

58. Phosphatidylethanol Homologs in Blood as Biomarkers for the Time Frame and Amount of Recent Alcohol Consumption
NATHALIE HILL-KAPTURCZAK, DONALD M. DOUGHERTY, JOHN D. ROACHE, TARA E. KARNS-WRIGHT, MARISA LOPEZ-CRUZAN AND MARTIN A. JAVORS

59. Metabolomics to Differentiate Alcohol Use Disorders From Social Drinkers and Alcohol-Naive Subjects
BAHARUDIN BRAHIM AND KESHAMALINI GOPALSAMY

60. Meconium Biomarkers of Prenatal Alcohol Exposure
ESTHER PAPASEIT, ROBERT MUGA, PAOLA ZULUAGA, ARANTZA SANVISENS AND MAGÍ FARRÉ

61. Applications of the Alcohol Use Disorders Identification Test (AUDIT) in Distinct Health Areas
MARÍA-TERESA CORTÉS-TOMÁS AND JOSÉ-ANTONIO GIMÉNEZ-COSTA

62. Craving Measurement and Application of the Alcohol Craving Experience Questionnaire
JASON M. COATES, GERALD F.X. FEENEY, MATTHEW J. GULLO, DAVID J. KAVANAGH, ROSS MCD. YOUNG, JON MAY, JACKIE ANDRADE AND JASON P. CONNOR

PART VII: TREATMENTS, STRATEGIES AND RESOURCES

63. Negative Emotions and Alcohol Use Disorder Treatment
MATT G. KUSHNER AND JUSTIN J. ANKER

64. Use of Baclofen in Alcohol Use Disorder: A Clinical Approach
BRUCE IMBERT

65. Baclofen-Induced Neurotoxicity
MAGALI CHARTIER, LUCIE CHEVILLARD AND BRUNO MÉGARBANE

66. Treatment With Nalmefene in Alcoholism
PHILIPPE LARAMÉE

67. Dual Therapy for Alcohol Use Disorders: Combining Naltrexone With Other Medications
JANICE FROEHLICH, EMILY NICHOLSON AND JULIAN DILLEY

68. The Avermectin Family as Potential Therapeutic Compounds for Alcohol Use Disorder: Implications for Using P2X4 Receptor as a Drug-Screening Platform
NHAT HUYNH, SHERAZ KHOJA, LIANA ASATRYAN, MICHAEL W. JAKOWEC AND DARYL L. DAVIES

69. Alcohol Withdrawal Syndrome: Clinical Picture and Therapeutic Options
SARAH JESSE AND ALBERT LUDOLPH

70. Resources for the Neuroscience of Alcohol
RAJKUMAR RAJENDRAM AND VICTOR R. PREEDY

Product details

  • Edition: 1
  • Latest edition
  • Published: March 19, 2019
  • Language: English

About the editor

VP

Victor R. Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

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