Neuroplasticity
From Bench to Bedside
- 1st Edition, Volume 184 - January 14, 2022
- Editors: Angelo Quartarone, Maria Felice Ghilardi, Francois Boller
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 4 1 0 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 9 4 1 1 - 9
Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summ… Read more
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- Includes inflammation, autoimmunity, genetics, neurophysiology, and more
- Encompasses stroke, Alzheimer’s, movement and psychiatric disorders
- Provides tools for enhancing recovery
- Cover
- Title page
- Table of Contents
- Copyright
- Handbook of Clinical Neurology 3rd Series
- Foreword
- Preface
- Contributors
- Section I: Introduction
- Chapter 1: Defining neuroplasticity
- Abstract
- Introduction
- Developmental Plasticity
- Myelin Plasticity
- Adult Plasticity
- Adaptive vs Maladaptive Plasticity
- Conclusions
- Acknowledgments
- References
- Section II: Neuroplasticity: Basic mechanism and assessment at system level
- Chapter 2: Basic mechanisms of plasticity and learning
- Abstract
- Introduction
- Synaptic and Neuronal Basis of Learning and Memory
- Molecular Mechanisms of Synaptic Long-Term Changes: Lessons From the Hippocampus
- The Nucleus Striatum and the Dopaminergic Regulation of Synaptic Plasticity
- From Bench to Bedside: Synaptic Plasticity Failure in Neurologic Disorders
- Conclusions
- References
- Chapter 3: Local sleep: A new concept in brain plasticity
- Abstract
- Introduction
- Global Changes in Brain Activity During Sleep
- Slow Waves and Spindles
- Local Patterns of Brain Activity During Sleep
- Local, Experience-Dependent Regulation of Sleep Slow Waves
- Sleep Slow Wave Activity as a Marker of Brain Structural Adaptations
- Experience-Dependent Local Sleep During Wakefulness
- Local Regulation of Sleep in Pathologic Conditions
- Approaches for the Modulation of Sleep Slow Waves
- Conclusions and Future Directions
- References
- Chapter 4: Sleep and homeostatic control of plasticity
- Abstract
- Introduction
- Sleep, Homeostasis and Plasticity
- The Homeostatic Control of Plasticity During Sleep
- Multidimensional Assessment of Sleep and Homeostatic Control of Plasticity
- Implications Of neural Plasticity and Sleep Homeostasis for the Diagnosis and Treatment of Sleep Disorders
- Concluding Remarks
- References
- Chapter 5: Transcranial magnetic stimulation as a tool to induce and explore plasticity in humans
- Abstract
- Introduction
- Theta Burst Stimulation (TBS)
- Paired Associative Stimulation (PAS)
- Transcranial Direct Current Stimulation (tDCS)
- Metaplasticity
- Variability in Brain Stimulation Protocols
- Future Perspectives and Conclusions
- References
- Chapter 6: EEG as a marker of brain plasticity in clinical applications
- Abstract
- Introduction
- Plasticity in Normal Subjects is Defined by Learning and Environmental Changes
- Plasticity in Neurologic Diseases
- Conclusion and Future Perspectives
- References
- Further reading
- Chapter 7: Tools to explore neuroplasticity in humans: Combining interventional neurophysiology with functional and structural magnetic resonance imaging and spectroscopy
- Abstract
- Introduction
- The Combination of NTBS and Neuroimaging Creates Mutual Benefits
- Matchmaking Between Brain Stimulation and Imaging
- “Offline Approach”: Informing and Evaluating Stimulation After-Effects With MRI
- “Online Approach”: Ensuring and Evaluating State-Dependent Engagement With MRI
- Possibilities and Perspectives for Neuroimaging and Brain Stimulation Techniques
- Concluding Remarks
- References
- Chapter 8: Metabolic imaging and plasticity
- Abstract
- Introduction to Metabolic Imaging
- Identifying Regional Metabolic Abnormality: A Univariate Approach
- Understanding the Brain Networks: A Methodological Perspective
- Abnormal Brain Networks in Movement Disorders
- Dissecting Adaptive and Maladaptive Changes
- Investigating Neuroplasticity
- Conclusions
- Acknowledgments
- References
- Section III: Neuroplasticity in movement disorders
- Chapter 9: Parkinson's disease: Alterations of motor plasticity and motor learning
- Abstract
- Introduction
- Motor Learning in PD
- Motor Cortical Plasticity in PD
- Cerebellar Modulation of Plasticity in PD
- Connection Between the Basal Ganglia and M1
- Cortical Plasticity Studies Using TBS Protocols
- Cortical Plasticity Studied With Standard rtms Protocols
- rTMS as Treatment for Motor Symptoms
- Treatment of Depression and Other Nonmotor Symptoms in PD
- Deep TMS
- Transcranial Direct Current Stimulation (tDCS) in PD
- Transcranial Alternating Current Stimulation (tACS) in PD
- Concluding Remarks
- References
- Further reading
- Chapter 10: Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease
- Abstract
- Introduction
- Structure and Conformational Properties of α-Synuclein
- The Relationship Between Gene Mutations and the Development of Parkinson's Disease
- The Fields of Action of Alpha-Synuclein
- The Postsynaptic Functions of α-Synuclein
- Conclusions
- Acknowledgments
- References
- Chapter 11: Plasticity, genetics, and epigenetics in l-dopa-induced dyskinesias
- Abstract
- Introduction
- LIDs Pathophysiology and Aberrant Plasticity
- Genetics of LIDs
- Epigenetics of LIDs
- Conclusions
- References
- Chapter 12: Noninvasive neuromodulation in Parkinson's disease: Neuroplasticity implication and therapeutic perspectives
- Abstract
- Introduction
- The Contribution of NIBS to the Understanding of PD Pathophysiology
- The Rationale for Using Brain Stimulation for Treatment of PD
- Clinical Effects of Stimulation Techniques in PD: The State of the Art
- Conclusions, Research Needs and Future Perspectives
- References
- Chapter 13: Plasticity, genetics and epigenetics in dystonia: An update
- Abstract
- Introduction
- Modeling of Dystonia
- Synaptic Plasticity in the Basal Ganglia
- Abnormal Striatal Plasticity in a Mouse Model of DYT1 Dystonia
- Epigenetics
- Therapeutical Targets and Clinical Trials
- Conclusions
- References
- Chapter 14: Neuroplasticity in dystonia: Motor symptoms and beyond
- Abstract
- Introduction
- Motor Symptoms and Plasticity
- Non motor symptoms of dystonias and plasticity
- Conclusions
- References
- Section IV: Brain oscillations in neurological disorders
- Chapter 15: General principles of brain electromagnetic rhythmic oscillations and implications for neuroplasticity
- Abstract
- Introduction
- Conclusions
- Acknowledgment
- References
- Chapter 16: Noninvasive brain stimulation and brain oscillations
- Abstract
- Brain Oscillations and Behavior
- Brain Oscillations in Brain Disorders and Their Modulation
- Transcranial Alternating Current Stimulation
- Transcranial Direct Current Stimulation
- References
- Chapter 17: Brain oscillatory dysfunctions in dystonia
- Abstract
- Clinical Presentation and Treatment Options for Dystonia
- Intracerebral Recordings From Human Basal Ganglia
- Pattern Changes in Multiunit Activity Reflect Altered Output of Subcortical Structures
- Abnormal Oscillatory Pattern as a Sign of Pathologic Input to Basal Ganglia Nuclei
- Impaired Network Connectivity Shown by Simultaneous Cortical and Subcortical Recordings
- Local and Distant Effects of Deep Brain Stimulation on Oscillations
- Perspectives
- References
- Chapter 18: Brain oscillations and Parkinson disease
- Abstract
- Introduction
- OFF-Medication Theta Oscillations
- ON-Medication Theta Oscillations
- Beta Oscillations
- Gamma Oscillations
- High-Frequency Oscillations (HFOs)
- Brain Oscillations and DBS
- Conclusions
- References
- Chapter 19: Adaptive deep brain stimulation: Retuning Parkinson's disease
- Abstract
- Introduction
- Input Signals: The different approaches to aDBS
- Concluding Remarks
- References
- Section V: Plasticity and rehabilitation
- Chapter 20: Biomarkers of plasticity for stroke recovery
- Abstract
- Introduction
- Spontaneous Biological Recovery
- Plasticity After Stroke
- Therapeutic Opportunities
- Biomarkers in Stroke Recovery
- Structural Imaging for Prediction
- Functional Imaging for Prediction
- Biomarkers of Recovery Mechanisms
- Conclusions
- References
- Chapter 21: New tools for shaping plasticity to enhance recovery after stroke
- Abstract
- Introduction
- Functional Recovery After Stroke: The Role of Neuroplasticity
- Transcranial Magnetic Stimulation
- Transcranial Electrical Stimulation
- Transcranial Direct Current Stimulation
- Transcranial Alternating Current Stimulation
- Transcranial Random Noise Stimulation
- Vagal Nerve Stimulation
- Extremely Low-Frequency Magnetic Fields
- Conclusions
- References
- Chapter 22: Neuroplasticity of spinal cord injury and repair
- Abstract
- Introduction
- Normal Organization of the Descending Motor Pathways and Spinal Motor Systems
- Activity-Dependent Corticospinal Tract and Proprioceptive Afferent Plasticity in the Healthy Spinal Cord
- Neuropathologic Changes After SCI
- Maladaptive Plasticity Underlying Motor Impairment After SCI
- Neural Activity-Dependent Plasticity to Repair Spinal Cord Motor Circuits
- Combining Plasticity Mechanisms to Restore Function After SCI
- Overall Conclusions
- References
- Chapter 23: Reward and plasticity: Implications for neurorehabilitation
- Abstract
- Neuroplasticity in Rehabilitation
- Principles of Motor Learning
- What is a Reward?
- Reward and Feedback
- Neural Events Associated With Reward Presentation
- Reward and Motor Learning
- Reward and Rehabilitation
- Conclusion
- References
- Chapter 24: Rehabilitation in movement disorders: From basic mechanisms to clinical strategies
- Abstract
- Dysfunctional Plasticity in Movement Disorders
- Harnessing Plasticity Through Rehabilitation in Movement Disorders
- Rehabilitative Interventions in Movement Disorders
- Concluding Remarks
- References
- Chapter 25: Rehabilitation of visual perception in cortical blindness
- Abstract
- Background
- Approaches to Visual Rehabilitation for Cortical Blindness
- Measuring Vision Loss after Occipital Stroke
- Natural History of Occipital Stroke: Recent Insights into the Dynamics of Vision Loss
- Preserved Visual Pathways: Substrates for Visual Rehabilitation
- Use of Vision Restoration Training in Cortical Blindness (Figs. 25.1B and 25.2)
- Limitations of Training in the Chronic Period After Occipital Stroke
- Mounting Evidence for Benefits of Earlier Intervention After V1 Stroke
- Safety of Vision Training Early after Stroke
- Adjuvants to Behavioral Training for Vision Rehabilitation
- Conclusions
- References
- Chapter 26: The role of plasticity in the recovery of consciousness
- Abstract
- The Boundaries of Consciousness
- A Brief Clinical Overview on DOCs
- Anatomical and Pathophysiologic Correlates of DOCs
- Where and How Plastic Changes May Restore Consciousness: An Open Question
- Interventions to Promote Plastic Changes for Consciousness Recovery in Prolonged DOCs
- Concluding Remarks and Future Directions
- Acknowledgments
- References
- Chapter 27: Plasticity of the language system in children and adults
- Abstract
- Introduction
- Developmental Plasticity of Language
- Language Plasticity after Developmental Brain Injury
- Language Plasticity After Injury in Adults
- Conclusions
- Acknowledgments
- References
- Section VI: Inflammation, autoimmunity, and plasticity
- Chapter 28: Synaptic dysfunction in early phases of Alzheimer's Disease
- Abstract
- Introduction
- A Quarter of a Century of the Amyloid Hypothesis
- Amyloid and the Glutamatergic Synapse
- Tau Pathology at the Synapse
- Conclusions
- References
- Chapter 29: T cells, α-synuclein and Parkinson disease
- Abstract
- Introduction
- Roles for α-Synuclein in PD
- Implications of Aggregation and Accumulation for Autoimmunity
- α-Syn Accumulation in Antigen Presenting Cells
- The Enteric System and PD
- Evidence of Altered Inflammatory Pathways in PD
- Lymphocyte Roles in PD
- A Role for MHC Proteins in PD Pathogenesis
- A Connection Between Innate Immunity and Antigen Presenting Cells
- α-Syn as an Autoimmune Neoantigen in PD
- Implications for Diagnosis and Therapeutics
- Summary
- Acknowledgments
- References
- Chapter 30: Multiple sclerosis: Inflammation, autoimmunity and plasticity
- Abstract
- Introduction
- Neuro-Immune Crosstalk in MS
- Synaptic Inflammation in MS: Preclinical Studies
- Synaptic Activity in Patients With MS
- Synaptic Plasticity in Patients With MS
- Synaptic Plasticity Expression and Clinical Recovery in MS
- Inflammation Negatively Influences the Course of MS
- Possible Approaches to Boost Synaptic Plasticity in MS
- Conclusions
- References
- Section VII: Plasticity in cognitive and psychiatric disorders
- Chapter 31: Alzheimer disease and neuroplasticity
- Abstract
- Introduction
- Synaptic Dysfunction in AD
- Neuroplasticity in AD
- TMS to Measure Neuroplasticity in AD
- TMS-Based Biomarkers in AD
- TMS-Based Therapeutics in AD
- Conclusions
- References
- Chapter 32: From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment
- Abstract
- Introduction
- Anxiety Control Within the Brainstem Modulatory Network: Projections to SN
- Brainstem Modulatory Afferents and Vulnerability of SN Neurons to PD: Role of Chronic Stress
- Stress-Induced Neuromodulation of SN's Axon Initial Segment: A Risk Factor for Neurodegeneration
- SN's AIS Stem From Axon-Bearing Dendrites
- Outlook
- Acknowledgments
- References
- Chapter 33: Shaping plasticity with non-invasive brain stimulation in the treatment of psychiatric disorders: Present and future
- Abstract
- Summary
- References
- Index
- No. of pages: 534
- Language: English
- Edition: 1
- Volume: 184
- Published: January 14, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780128194102
- eBook ISBN: 9780128194119
AQ
Angelo Quartarone
MG
Maria Felice Ghilardi
FB
Francois Boller
François Boller, M.D., Ph.D. has been co-Series Editor of the Handbook of Clinical Neurology since 2002. He.is a board-certified neurologist currently Professor of Neurology at the George Washington University Medical School (GW) in Washington, DC. He was born in Switzerland and educated in Italy where he obtained a Medical Degree at the University of Pisa. After specializing in Neurology at the University of Milan, Dr. Boller spent several years at the Boston VA and Boston University Medical School, including a fellowship under the direction of Dr. Norman Geschwind. He obtained a Ph.D. in Experimental Psychology from Case Western Reserve University in Cleveland, Ohio where he was in charge of Neuroscience teaching at the Medical School and was nominated Teacher of the Year. In 1983, Dr. Boller became Professor of Neurology and Psychiatry at the University of Pittsburgh where he founded and directed one of the first NIH funded Alzheimer Disease Research Centers in the country. In 1989, he was put in charge of a Paris-based INSERM Unit dedicated to the neuropsychology and neurobiology of cerebral aging. He returned to the United States and joined the NIH in 2005, before coming to GW in July 2014.
Dr. Boller’s initial area of interest was aphasia and related disorders; he later became primarily interested in cognitive disorders and dementia with emphasis on the correlates of cognitive disorders with pathology, neurophysiology and imaging. He was one of the first to study the relation between Parkinson and Alzheimer disease, two processes that were thought to be unrelated. His current area of interest is Alzheimer’s disease and related disorders with emphasis on the early and late stages of the disease. He is also interested in the history of Neurosciences and is Past President of the International Society for the History of Neurosciences. He was the founding Editor-in-Chief of the European Journal of Neurology, the official Journal of the European Federation of Neurological Societies (now European Academy of Neurology). He is a Fellow of the American Academy of Neurology and a member of the American Neurological Association. In addition, he has chaired Committees within the International Neuropsychological Society, the International Neuropsychology Symposium, and the World Federation of Neurology (WFN). He has authored over 200 papers and books including the Handbook of Neuropsychology (Elsevier).