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Neurophotonics and Biomedical Spectroscopy

1st Edition - November 22, 2018

Editors: Robert R. Alfano, Lingyan Shi

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 4 8 0 6 7 - 3

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 4 8 0 6 8 - 0

Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of… Read more

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Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer’s disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures.

Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more.

Robert R. Alfano

Robert A. Alfano is Distinguished Professor and Fellow at The City College of City University of New York, USA. He is also an Optical Society of America; Fellow, and a Fellow of IEEE. He has been involved in developing ultrafast laser spectroscopic techniques and applications of these techniques to study ultrafast dynamical processes in physical, chemical, and biological systems. His research encompasses the study and development of supercontinuum, tunable solid-state lasers, nonlinear optical processes, application of optical spectroscopic techniques for medical diagnosis (optical biopsy), study of photon migration in turbid media, and development of optical imaging techniques for biomedical imaging (optical mammography). He has published more than 700 papers and holds 102 patents.

Affiliations and expertise

Professor and Fellow, The City College of City University of New York, USA

Lingyan Shi

Lingyan Shi is an Assistant Professor in the Department of Bioengineering at the UC San Diego Jacobs School of Engineering. She is developing and applying new ultrafast laser scanning optical imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS) microscopy for solving biological questions. Her recent major scientific contributions include the discovery of the “Golden Optical Window” for deep brain imaging, and the development of a breakthrough platform that combines deuterium probing with SRS for optical imaging of metabolic dynamics in living organisms. She is combining bioorthogonal labeling and SRS imaging for directly visualizing complex molecular events in brain, tumor, and metabolic diseases at sub-cellular scale in situ, which offer powerful tools potentially for disease detection, diagnosis and treatment, as well as for mechanistic understanding of scientific fundamentals. Shi is a member of OSA, SPIE, and also a member of New York Academy of Science.

Affiliations and expertise

Research Scientist, Columbia University, USA