Neuromuscular Disorders
Treatment and Management
- 2nd Edition - June 29, 2021
- Imprint: Elsevier
- Editor: Tulio E. Bertorini
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 1 3 1 7 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 2 0 9 3 - 9
Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools a… Read more
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Request a sales quoteOffering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications.
Provides comprehensive coverage of evaluation and diagnosis, treatments, and outcomes, including the latest management tools and targeted therapeutic strategies.
Includes the latest updates in the field: genetic causes of hereditary disease, new autoimmune diseases, promising new therapies such as antisense oligonucleotides and gene therapies, and more.
Features numerous drug tables, treatment algorithms, and clinical images throughout to aid in diagnosis and treatment.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Neurologists, Neurology Residents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Acknowledgments
- Contributors
- Part 1. General Principles in the Treatment and Management of Neuromuscular Disorders
- 1. Introduction: Evaluation of Patients with Neuromuscular Disorders
- Medical History and Symptoms
- Physical Examination
- Diagnostic Tests
- Electrophysiologic Tests
- Histologic Tests
- Imaging Studies
- Genetic Testing
- 2. Respiratory Complications in Neuromuscular Disorders
- Management of Neuromuscular Diseases Resulting In Respiratory Insufficiency
- Management of Neuromuscular Diseases Resulting In Acute Hypercarbic Respiratory Failure
- Acute Exacerbations of Chronic Neuromuscular Respiratory Failure
- 3. Cardiac Complications of Neuromuscular Disorders
- Duchenne Muscular Dystrophy
- Becker Muscular Dystrophy
- Carriers of Duchenne Muscular Dystrophy and Becker Muscular Dystrophy
- X-Linked Dilated Cardiomyopathy
- Limb-Girdle Muscular Dystrophy
- Myotonic Dystrophy
- Emery-Dreifuss Muscular Dystrophy
- Facioscapulohumeral Dystrophy
- Other Neuromuscular Disorders
- Diagnosis and Evaluation
- Pathology
- Treatment
- Preoperative Assessment
- Respiratory Therapy
- Genetic-Based Therapies
- Monitoring
- Summary
- Conclusion
- 4. Gastrointestinal Complications of Neuromuscular Disorders
- Introduction
- Pharynx and Esophagus
- Stomach and Duodenum
- Small Intestine
- Large Intestine and Anal Sphincter Constipation
- Incontinence
- Liver and the Hepatobiliary System
- Peripheral Neuropathy and the Gastrointestinal System
- Conclusions
- 5. Autonomic Dysfunction in Neuromuscular Disorders
- Overview of the Autonomic Nervous System
- Evaluation of the Autonomic Nervous System
- Types of Autonomic Neuropathy
- Autonomic Disorders—Other
- Symptomatic Treatment of Autonomic Disorders
- 6. A Practical Approach to the Treatment of Painful Polyneuropathies
- Definitions and Overview
- Nerve Anatomy
- Overview of Peripheral Neuropathic Pain Pathophysiology
- Modification of Sensory and Nociceptive Afferents
- Evidence-Based Medicine
- Approved and “Off-Label” Medication Uses
- Previous Treatment Recommendations
- General Approach to the Patient with Painful Neuropathy
- “First-Line” Neuropathic Pain Treatments
- “Second-Line” Neuropathic Pain Treatments
- Ancillary Treatments
- Conclusion
- 7. Principles and Guidelines of Immunotherapy in Neuromuscular Disorders
- Basics of the Immune Response
- Autoimmunity
- Immunotherapy
- Evidence-Based Medicine and Treatment of Autoimmune Neuromuscular Disorders
- 8. Rehabilitation in Neuromuscular Disorders
- Management of Muscle Weakness
- Orthoses and Mobility Aids
- Lower Extremity
- Assistive Devices for Activities of Daily Living
- Environmental Evaluations and Modifications
- Orthopedic Considerations
- Respiratory Failure
- Dysarthria
- Dysphagia
- Pain
- Mood Disorders
- Cognitive Dysfunction
- Quality of Life
- Roles of the Caregiver and Family
- Palliative Care and Hospice
- 9. Orthopedic Surgery in Neuromuscular Disorders
- Muscular Dystrophy
- Hereditary Motor and Sensory Neuropathies
- 10. Perioperative Management of Patients With Neuromuscular Disorders
- Introduction
- Characteristics of Physiologic Abnormalities
- Preoperative Management
- Intraoperative Management
- Postoperative Management
- Perioperative Management in Specific Neuromuscular Disorders
- Malignant Hyperthermia Syndrome
- Complications of Major Surgery and Organ Transplantation
- Neuromuscular Disorders Acquired in the Intensive Care Unit
- 11. Molecular and Genetic Therapies
- Prevalence of Hereditary NMD
- Overview of Genetics
- Genetic Testing In NMDs
- Genetic Approaches to Treatment of Neuromuscular Disorders
- Part 2. Treatment and Management of Specific Neuromuscular Disorders
- 12. Treatment and Management of Adult Motor Neuron Diseases
- Diagnosis And Evaluation
- Treatment And Management
- 13. Treatment and Management of Spinal Muscular Atrophy and Congenital Myopathies
- Introduction
- Diagnosis and Evaluation
- Treatment and Management
- Current Therapies
- Conclusion
- 14. Treatment and Management of Hereditary Neuropathies
- Overview of Inherited Neuropathies
- Nonsyndromic Inherited Neuropathies
- Syndromic Inherited Neuropathies
- Conclusions
- 15. Treatment and Management of Autoimmune Neuropathies
- Introduction
- Acute Autoimmune Peripheral Neuropathies
- Guillain-Barré Syndrome Subtypes
- Chronic Autoimmune Peripheral Neuropathies
- 16. Treatment and Management of Infectious, Granulomatous, and Toxic Neuromuscular Disorders
- Infections of Nerve and Muscle
- Granulomatous Diseases of Nerve and Muscle
- Toxic Neuropathies and Myopathies
- 17. Treatment and Management of Segmental Neuromuscular Disorders
- Radiculopathy
- Plexopathies
- Focal Neuropathies
- Focal Neuropathy Syndromes
- 18. Treatment and Management of Disorders of Neuromuscular Hyperexcitability and Periodic Paralysis
- Disorders of Neuromuscular Hyperexcitability
- Central Disorders
- Disorders of Peripheral Nerve Hyperexcitability
- Primary Disorders of Muscle
- Brody Disease
- Metabolic Myopathies
- 19. Treatment and Management of Disorders of the Neuromuscular Junction
- Myasthenia Gravis
- Lambert-Eaton Myasthenic Syndrome
- Botulism
- Congenital Myasthenic Syndrome
- Snakebite Myasthenic Syndrome
- Organophosphate Intoxication
- Hypermagnesemia-Induced Paralysis
- 20. Treatment and Management of Muscular Dystrophies
- Dystrophinopathies
- Limb-Girdle Muscular Dystrophies
- Emery-Dreifuss Muscular Dystrophy
- Facioscapulohumeral Muscular Dystrophy
- Myotonic Dystrophy
- Oculopharyngeal Muscular Dystrophy
- Congenital Muscular Dystrophy
- 21. Neuromuscular Manifestations of Acquired Metabolic, Endocrine, and Nutritional Disorders
- Endocrine Disorders
- Neuromuscular Complications of Uremia
- Malnutrition and Vitamin Deficiencies
- 22. Treatment and Management of Autoimmune Myopathies
- Dermatomyositis
- Polymyositis
- Necrotizing Autoimmune Myositis (Also Referred to as Immune-Mediated Necrotizing Myopathy)
- Antisynthetase Syndrome” or “Overlap Myositis” or “Anti-Jo-1 Syndrome”
- Inclusion Body Myositis
- Eosinophilic Syndromes and Fasciitis
- Diagnosis and Evaluation
- Presence of Autoantibodies
- Treatment and Management of Inflammatory Myopathies
- 23. Treatment and Management of Hereditary Metabolic Myopathies
- Muscle Disorders of Glycogen Metabolism
- Muscle Disorders of Lipid Metabolism
- Mitochondrial Myopathies
- Rhabdomyolysis
- Conclusion
- Index
- Edition: 2
- Published: June 29, 2021
- Imprint: Elsevier
- No. of pages: 624
- Language: English
- Hardback ISBN: 9780323713177
- eBook ISBN: 9780323720939
TB
Tulio E. Bertorini
Dr. Bertorini is a Professor at the University of Tennessee Health Sciences Center in Memphis. He specializes in neuromuscular disease and is the director of the Memphis MDA Clinic and the Mid-South MDA/ALS Clinic. He is also the Chief of Neurology at Methodist University Hospital, Co-Director of their Neurology Training Program, and Co-Director of UTHSC’s Neurophysiology fellowship program. Dr. Bertorini has written/edited three books and several book chapters on neuromuscular disorders and has published over 150 papers on neuromuscular disorders. He has been very active in clinical research in Duchene Muscular Dystrophy and CINRG trials since its inception.
Affiliations and expertise
Professor of Neurology and Pathology, University of Tennessee, Center for Health Science Center, Memphis; Chief of Neurology, Methodist University Hospital; Director, Wesley Neurology Clinic and Muscular Dystrophy and ALS Clinic, Memphis, TN, USARead Neuromuscular Disorders on ScienceDirect