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Elsevier

Neurochemical Substrates of Addiction Medicine

  • 1st Edition - January 1, 2027
  • Latest edition
  • Editors: Mohammad Banazadeh, Mohammad Navid Ebrahimi, Mohammad Shabani
  • Language: English

Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for resear… Read more

Description

Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction. Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating. With its integrative approach, this book is an essential resource for understanding the neurochemical foundations of addiction and the implications for treatment and intervention strategies.

Key features

  • Clarifies the role of neuroplasticity in addiction recovery and how changes in brain circuitry can influence therapeutic outcomes
  • Illustrates the impact of genetic and environmental factors on individual susceptibility to addiction through case studies and research findings
  • Highlights the significance of emerging treatments, including pharmacogenetics and personalized medicine, in addressing various forms of addiction
  • Discusses the relationship between co-occurring mental health disorders and addiction, emphasizing integrated treatment approaches
  • Provides practical guidelines for clinicians on assessing and managing addiction using a neurochemical framework to enhance patient care

Readership

Students and early researchers in neuroscience, addiction, and clinicians treating patients with addiction including psychiatrists, psychologists

Table of contents

Section 1: The distribution of neurotransmitters in the brain circuitry and Addiction

1. Mesolimbic circuitry

2. Striatal circuitry

3. Frontal circuitry

4. Insular circuitry

5. Thalamic circuitry

Section 2: Addiction medicine in the context of neurotransmitter systems

6. Introduction

7. Dopaminergic system

8. Glutamatergic system

9. GABAergic system

10. Adrenergic systems

11. Serotonergic system

12. Cholinergic system

13. Endogenous opioid system

14. Purinergic system

Section 3: The drugs of abuse

15. Nicotine

16. Opioids

17. Alcohol

18. Psychomotor stimulants

19. Cannabinoids

20. Psychedelics

21. Sedative hypnotics

22. Caffeine

23. Antihistamines

Section 4: Behavioral addiction

24. Pathological gambling disorder

25. Internet use disorder and pathological gaming disorder

26. Sexual addiction and pornography use disorder

27. Binge eating disorder

Product details

  • Edition: 1
  • Latest edition
  • Published: January 1, 2027
  • Language: English

About the editors

MB

Mohammad Banazadeh

Dr. Mohammad Banazadeh earned his PharmD. degree from Kerman University of Medical Sciences in 2019. Since then he has been working as a Research Assistant in Kerman Neuroscience Research Center and Pharmaceutical Sciences and Cosmetic Products Research Center. He is enthusiastic of science especially of Neuroscience, which has been his favourite topic since he was young.

Affiliations and expertise
Kerman University of Medical Sciences, Iran

ME

Mohammad Navid Ebrahimi

Dr. Mohammad Navid Ebrahimi completed his PhD in Neuroscience at Kerman Neuroscience Research Center. He has been working as a researcher since his Masters studies in the field of Medical Physiology. He currently serves as an Assistant Professor in the Department of Psychiatry at Kerman University of Medical Sciences, where he also contributes to the Neuroscience Research Center. His main research interests are addiction and cognitive impairments.

Affiliations and expertise
Kerman Neuroscience Research Center, Iran

MS

Mohammad Shabani

Professor Mohammad Shabani acquired a PhD in 2010 from the Shahid Beheshti University of Medical Sciences. He earned a fellowship training in calcium imaging and intracellular recording at the Copenhagen University (Department of drug design and pharmacology) in 2018. Professor Shabani earned the honor of the full professorship of Kerman Medical University since the second half of 2018. He is an academic member in the Department of Neuroscience in Kerman Neuroscience Research Center (KNRC) (since 2005). He has been the Chair of Research community of KNRC for 8 years. Professor Shabani chaired the intracellular recording lab of KNRC between 2011 and 2023. So far, Professor Shabani has contributed to authoring more than 150 papers in prestigious journals and authoring one book.

Affiliations and expertise
Kerman Medical University, Iran