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Neonatology Questions and Controversies: The Newborn Lung
- 4th Edition - October 6, 2023
- Editors: Eduardo Bancalari, Richard A. Polin, Martin Keszler, Peter G Davis
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 8 7 4 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 7 9 3 5 - 4
Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trust… Read more
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Institutional subscription on ScienceDirect
Request a sales quoteDr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.
The thoroughly updated, full-color, 4th Edition of The Newborn Lung:
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Provides a clear management strategy for reducing lung damage and long-term sequelae in extremely premature infants, offering guidance based on the most up-to-date understanding of underlying pathophysiology.
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Places emphasis on controversial areas that can entail different approaches.
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Features the most current clinical information throughout, with an emphasis on those areas where there have been major new developments in recent years.
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Includes new chapters on Perinatal Nutrition and the Lung; Caffeine: Respiratory Stimulant or Magic Bullet?; Lung Ultrasound and Electrical Impedance Tomography; New Lung Imaging Techniques: CT, MRI and Other Modalities; Alveolar Homeostasis and Chronic Lung Disease; and Fetal Intervention in Congenital Malformations of the Respiratory System.
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Utilizes a consistent chapter organization to help you find information quickly and easily, and contains numerous charts, graphs, radiographic images, and photographs throughout.
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Offers the most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Purchase each volume individually, or get the entire 7-volume Neonatology Questions and Controversies set, which includes online access that allows you to search across all titles!
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Gastroenterology and Nutrition
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Hematology and Transfusion Medicine
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Neonatal Hemodynamics
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Infectious Disease, Immunology, and Pharmacology
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Renal, Fluid, and Electrolyte Disorders
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Neurology
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The Newborn Lung
neonatologists, neonatal nurse practitioners, pediatricians
- Cover image
- Title page
- Table of Contents
- Other Volumes in the Neonatology Questions and Controversies Series
- Copyright
- Contributors
- Series Foreword
- Preface
- List of Illustrations
- List of Tables
- 1. Perinatal events and their influence on lung development and injury
- Overview of lung development and perinatal events
- Lung development: The substrate for adverse events
- Lung maturation
- Antenatal infection/inflammation
- Intrauterine growth restriction/small for gestational age (SGA)
- Environmental factors and lung disease
- Summary: The complexities
- References
- 2. Respiratory and cardiovascular support in the delivery room
- Understanding the transition to newborn life
- Anticipating and preparing for neonatal resuscitation
- Rapid assessment after birth
- Initial steps for nonvigorous and preterm newborns
- Effective ventilation: The key!
- Chest compressions during resuscitation in the delivery room
- Medications during resuscitation in the delivery room
- Discontinuing resuscitative efforts
- References
- 3. Vascular development and pulmonary hypertension
- Development of the fetal pulmonary circulation
- Physiology of the fetal pulmonary circulation
- Mediators of fetal pulmonary vascular development
- Transitional circulation and postnatal pulmonary vascular development
- Features of abnormal pulmonary vascular development
- Factors that disrupt fetal pulmonary vascular development
- Clinical implications and controversies
- Pulmonary hypertension treatment: Concepts and controversies
- Conclusions
- References
- 4. Airway microbiome and lung injury
- Introduction
- Newborn lung microbiome
- Role of Ureaplasma species in intrauterine infection and neonatal lung injury
- Developmental deficiencies in innate immunity contribute to susceptibility to Ureaplasma infection and dysregulated inflammation
- Can bronchopulmonary dysplasia be prevented by Ureaplasma eradication?
- Summary
- References
- 5. Ventilator-associated pneumonia
- Introduction
- Definition
- Epidemiology
- Pathogenesis
- Treatment
- Prevention
- Outcomes
- Future research directions
- Conclusion
- References
- 6. Noninvasive respiratory support for preterm infants: An alternative to mechanical ventilation
- Introduction
- Why do preterm infants experience respiratory failure and how can noninvasive respiratory support help?
- A brief history of neonatal mechanical ventilation and noninvasive respiratory support
- Nasal continuous positive airway pressure
- Nasal intermittent positive-pressure ventilation
- Summary and recommendations
- Noninvasive high-frequency ventilation
- Nasal high flow
- Future directions
- Acknowledgments
- References
- 7. Newer strategies for surfactant delivery
- Introduction
- Techniques of surfactant administration without an endotracheal tube
- Surfactant administration via brief tracheal catheterization
- Surfactant administration via brief tracheal catheterization—scientific and practical considerations
- Surfactant administration via brief tracheal catheterization—recommendations
- Surfactant administration via brief tracheal catheterization—future research directions
- References
- 8. Respiratory control and oxygen instability in premature infants
- Introduction
- Biological challenges in characterizing neonatal respiratory control
- Central respiratory control
- Central and peripheral chemosensitivity
- Contribution from inflammatory mechanisms
- Clinical challenges in defining neonatal apnea
- Mechanisms of oxygenation instability
- Association between intermittent hypoxemia, bradycardia, and outcomes
- Mechanistic insights into morbidity
- Controversies in therapy
- References
- 9. Pulmonary-cardiovascular interaction
- Introduction
- Cardiorespiratory interactions at birth
- The physiology of cardiovascular and respiratory interaction
- Effect of the respiratory system on the cardiovascular system
- Effect of the cardiovascular system on the respiratory system
- Interaction during early transition and potential clinical implications
- Interaction after transition and potential clinical implications
- Conclusions
- References
- 10. Ventilator strategies to reduce lung injury and duration of mechanical ventilation
- Introduction
- Ventilator-associated lung injury
- How can we reduce VALI?
- Delivery room stabilization
- Noninvasive respiratory support
- Strategies of mechanical ventilation
- Basic modes of synchronized ventilation
- Synchronized intermittent mandatory ventilation
- Assist control
- Pressure support ventilation
- Choice of assisted ventilation modes
- Volume-targeted ventilation
- Importance of the open lung strategy
- High-frequency ventilation
- Evidence-based approach to mechanical ventilation
- Conflict of interest statement
- References
- 11. Prenatal and postnatal steroids and pulmonary outcomes
- Antenatal corticosteroids
- Postnatal steroids
- Summary and future directions
- References
- 12. Cell-based therapy for neonatal lung diseases
- Introduction
- Endogenous lung stem cells
- Cell therapies for neonatal lung diseases
- Conclusion
- References
- 13. Definitions and diagnostic criteria of bronchopulmonary dysplasia: Clinical and research implications
- Abbreviations
- Clinical presentation of bronchopulmonary dysplasia
- Bronchopulmonary dysplasia diagnosis
- Existing diagnostic criteria for bronchopulmonary dysplasia
- Competing outcomes
- Defining the populations at risk for bronchopulmonary dysplasia
- Prognosis for long-term pulmonary impairment
- Implications for future research
- Conclusion
- References
- 14. A physiology-based approach to the respiratory care of children with severe bronchopulmonary dysplasia
- Introduction
- Definitions and scope of severe bronchopulmonary dysplasia
- Pathogenesis of severe bronchopulmonary dysplasia
- Pathophysiology of severe bronchopulmonary dysplasia
- Evaluation and treatment of severe bronchopulmonary dysplasia
- Long-term outcomes
- Acknowledgments
- References
- 15. Long-term pulmonary outcome of preterm infants
- Controversies
- What are the long-term pulmonary outcomes for late preterm infants?
- What are the long-term pulmonary outcomes for very preterm infants, and what is the effect of having BPD on these outcomes?
- Are we improving expiratory airflow in survivors born extremely preterm over time in the post-surfactant era?
- What are the effects of cigarette smoking?
- Is there a role for caffeine in the newborn period?
- What further research is required?
- Summary
- References
- 16. Perinatal nutrition and the lung
- Introduction
- Prenatal nutrition and lung development
- Nutritional interventions for primary prevention of preterm birth
- Maternal undernutrition
- Maternal over nutrition
- Maternal intake of micronutrients
- Postnatal nutrition and respiratory outcomes
- Preterm infant nutrition
- Undernutrition, growth failure, and pulmonary consequences
- Adequate nutrition to support lung growth and function
- Conclusion
- References
- 17. Caffeine—respiratory stimulant or magic bullet?
- Introduction
- Caffeine is the respiratory stimulant of choice for preterm infants
- Caffeine for apnea of prematurity trial
- Remaining uncertainties about neonatal caffeine therapy
- Is caffeine a magic bullet?
- References
- 18. The neonatal lung: Lung imaging using ultrasound and electric impedance tomography
- Abbreviations
- Introduction
- Lung ultrasound
- Electrical impedance tomography
- Conclusions and future directions
- References
- 19. Genetic disorders of alveolar formation and homeostasis
- Genetic disorders of lung formation
- Mutations in genes in pulmonary mesenchyme
- Mutations in genes expressed in the embryonic epithelium (NKX2-1/TTF-1)
- Mutations in SOX2 and SOX9 are associated with multiple congenital malformations
- Critical role of pulmonary surfactant after birth
- Diffuse pulmonary disease caused by surfactant dysfunction
- Genetic disorders of surfactant homeostasis
- Inherited disorders of surfactant homeostasis: SP-B, SP-C, and ABCA3
- Surfactant protein B
- Surfactant protein C
- ABCA3: Disorder of lipid transport and lamellar body formation
- Clinical perspectives
- Recommended for review
- References
- 20. Fetal intervention in congenital malformations of the respiratory system
- Introduction
- Congenital diaphragmatic hernia
- Congenital lung masses or congenital pulmonary malformations
- Conclusions
- References
- Index
- No. of pages: 402
- Language: English
- Edition: 4
- Published: October 6, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323878746
- eBook ISBN: 9780323879354
EB
Eduardo Bancalari
Affiliations and expertise
Emeritus Professor of Pediatrics, Director Division of Neonatology, University of Miami School of Medicine, Miami, FloridaRP
Richard A. Polin
Affiliations and expertise
Director, Division of Neonatology and Perinatology,Professor of Pediatrics, Columbia University Medical CollegeMK
Martin Keszler
Affiliations and expertise
Professor of Pediatrics, Alpert Medical School of Brown University and Associate Director of NICU and Director of Respiratory Services, Women and Infants Hospital of Rhode Island, Providence, Rhode IslandPD
Peter G Davis
Affiliations and expertise
Professor and Director of Neonatal Medicine, Royal Women’s Hospital, University of Melbourne, Victoria, Australia