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Neonatology Questions and Controversies: Infectious Disease, Immunology, and Pharmacology
- 2nd Edition - October 31, 2023
- Editors: William Benitz, James L. Wynn, P. Brian Smith, Richard A. Polin
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 9 0 6 - 4
Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering… Read more
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Request a sales quoteThe thoroughly updated, full-color, 2nd Edition of Infectious Disease, Immunology, and Pharmacology:
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Provides a clear management strategy for common and rare neonatal infectious diseases, offering guidance based on the most up-to-date understanding of underlying pathophysiology.
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Places emphasis on controversial areas that can entail different approaches.
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Features the most current clinical information throughout, including a new immunology section that covers inborn errors of immunity presenting in the newborn period and clinical and molecular markers for diagnosis of neonatal sepsis.
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Includes new chapters on COVID-19; congenital syphilis; gonococcal eye prophylaxis; organ dysfunction in sepsis and necrotizing enterocolitis; and drug-associated acute kidney injury.
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Utilizes a consistent chapter organization to help you find information quickly and easily, and contains numerous charts, graphs, radiographic images, and photographs throughout.
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Offers the most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Purchase each volume individually, or get the entire 7-volume Neonatology Questions and Controversies set, which includes online access that allows you to search across all titles!
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Gastroenterology and Nutrition
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Hematology and Transfusion Medicine
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Neonatal Hemodynamics
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Infectious Disease, Immunology, and Pharmacology
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Renal, Fluid, and Electrolyte Disorders
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Neurology
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The Newborn Lung
neonatologists, neonatal nurse practitioners, pediatricians
- Cover image
- Title page
- Table of Contents
- Other Volumes in the Neonatology Questions and Controversies Series
- Copyright
- Contributors
- Series Foreword
- Preface
- List of Illustrations
- List of Tables
- SECTION 1. Infectious Disease
- 1. Management of the asymptomatic newborn at risk for sepsis
- Introduction
- Approaches to EOS risk assessment among well-appearing term infants
- Areas of controversy
- References
- 2. Empiric therapy for neonatal sepsis
- Early-onset sepsis
- Late-onset sepsis
- Low-resource settings
- Conclusion
- References
- 3. When and how to treat neonatal CMV infection
- Clinical significance
- Treatment of congenital CMV
- Treatment of postnatal CMV infection
- References
- 4. Neonatal herpes simplex virus infection
- Introduction
- Timing of infection
- Risk factors for neonatal infection
- Clinical manifestations of neonatal infection and disease
- Diagnosis of neonatal HSV disease
- Treatment of neonatal HSV disease
- Outcomes of neonatal HSV with treatment
- Approach to neonates exposed to active HSV lesions at delivery
- Prevention of neonatal HSV disease
- Conclusion
- References
- 5. Antibiotic stewardship
- Antibiotic stewardship programs: We were warned
- Early days: Reporting emergent resistance and antibiotic practice and outcome variation in NICUs
- Emergence of multicenter reports on antimicrobial practice variations
- Large-scale stewardship in the NICU
- NICUs join the antibiotic stewardship wave
- Ongoing challenges
- Actionable items
- References
- 6. Neonatal fungal infections
- How are invasive Candida infections defined?
- How does Candida cause invasive infections?
- What are predisposing factors for ICIs in the neonatal intensive care unit?
- What factors contribute to the virulence of Candida?
- Which organisms cause ICIs in the NICU?
- What is the incidence of ICIs in the NICU?
- What is the neurodevelopmental impairment impact and survival among infants who develop ICIs and what factors can improve these outcomes?
- What is the most common skin finding with CCC and how is it diagnosed and managed?
- How long are blood cultures positive with candidemia?
- What screening is needed to diagnose end-organ dissemination for each site of ICI?
- What are risk factors for renal candidiasis?
- Can meningitis and central nervous system involvement occur without candidemia?
- Is it more common for Candida peritonitis to occur with focal bowel perforation or nec?
- Is preemptive treatment indicated if Candida is isolated from an endotracheal culture?
- Endophthalmitis and retinopathy of prematurity
- Who are high-risk infants for whom antifungal prophylaxis could be considered?
- What is the average time required to identify Candida from culture?
- How good are the newer laboratory diagnostic adjunctive tests?
- Are cases of mold infections on the rise?
- References
- 7. When to perform lumbar puncture in infants at risk for meningitis in the neonatal intensive care unit
- Introduction
- Increased susceptibility to meningitis in premature infants
- Role of LP in the evaluation of early-onset sepsis
- Role of LP in the evaluation of late-onset sepsis
- Role of LP in viral meningitis
- Risks associated with LP in newborn infants
- Role of ultrasound in performing LPs
- Are there any contraindications to performing an LP in the newborn infant?
- LPs in the setting of antibiotic exposure: Are they useful?
- Emerging role of the BioFire FilmArray
- Repeating LPs in infants with meningitis: Is it necessary?
- LPs in infants with intraventricular drainage device–associated infection
- Summary
- References
- 8. Perinatal and neonatal considerations in COVID-19
- Introduction
- Prenatal and obstetrical considerations
- Neonatal COVID-19 diagnosis and management
- Ethical and psychosocial considerations
- References
- 9. Congenital syphilis
- Introduction
- Treponema pallidum
- Transmission
- Clinical significance and outcomes
- Diagnosis
- Treatment
- Special considerations
- Follow-up
- Summary
- References
- 10. Gonococcal eye prophylaxis—are mandates still justified?
- Introduction
- Macrolide resistance in N. gonorrhoeae
- Macrolide pharmacokinetic considerations in treatment of gonococcal conjunctivitis
- Efficacy of neonatal ocular prophylaxis for prevention of neonatal gonococcal conjunctivitis
- Impact of prenatal screening and treatment on the incidence of neonatal gonococcal ophthalmia
- Conclusions
- References
- 11. Organ dysfunction in sepsis and necrotizing enterocolitis
- Organ dysfunction severity
- The pathogen
- The host
- The treatment
- Organ dysfunction in sepsis and NEC by system
- Guidelines and monitoring
- Conclusion
- References
- SECTION 2. Pharmacology
- 12. Antibiotic considerations for necrotizing enterocolitis
- Pathogenesis of NEC
- Clinical presentation and diagnosis of NEC
- Antimicrobial therapy in the management of NEC
- Conclusion
- References
- 13. Antiseizure medications and treatments in neonates
- Introduction
- Antiseizure medications
- Other therapies
- Discontinuation of therapy
- Conclusion
- References
- 14. Neuroprotective therapies in newborns
- Introduction
- Neuroprotective therapies and strategies for premature infants
- Care bundles to reduce IVH and improve neurodevelopmental outcome
- Antenatal betamethasone
- Magnesium sulfate
- Caffeine
- Indomethacin
- Erythropoiesis-stimulating agents: Erythropoietin/darbepoetin
- Management of pain versus impact of analgesics and sedatives on the developing brain
- Neuroprotective strategies for term infants
- Clinically available treatments: Therapeutic hypothermia
- Therapies under study
- References
- 15. Pharmacological therapy of neonatal abstinence syndrome
- Terminology
- Problems in the management of NAS
- Clinical definition
- Clinical assessment
- Management of NAS
- Medications
- Weaning process
- Adjunct medications
- Conclusions
- References
- 16. Vasodilator drugs for pulmonary hypertension in bronchopulmonary dysplasia
- Introduction
- Pathophysiology and risk factors
- Diagnosis
- Management
- Drug safety and efficacy
- Drug influence on long-term outcomes
- Prevention of bronchopulmonary dysplasia
- Conclusions
- References
- 17. Drug-associated acute kidney injury in neonates
- Introduction
- Background
- Nephrotoxin-induced AKI
- Nephrotoxic medications
- Management of drug-associated AKI
- Long-term effects of drug-associated AKI in neonates
- References
- SECTION 3. Immunology
- 18. Recent advances and controversies in inborn errors of immunity presenting in the newborn period
- Inborn errors of immunity presenting in the newborn period
- Diagnostic approach to a neonate with suspected IEI
- Management and treatment of neonates with a suspected or known inborn error of immunity
- References
- 19. Clinical and molecular markers to assist decision-making in neonatal sepsis
- Introduction
- Decision-making in neonatal sepsis
- Conceptual framework for decision-making in neonatal sepsis
- Clinical markers of sepsis
- Molecular markers of neonatal sepsis
- Multimodal approaches
- Future perspectives
- Conclusions
- References
- Index
- No. of pages: 308
- Language: English
- Edition: 2
- Published: October 31, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323879064
WB
William Benitz
JW
James L. Wynn
PS
P. Brian Smith
RP