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Neonatology Questions and Controversies: Hematology and Transfusion Medicine
- 4th Edition - August 1, 2023
- Editors: Robin K Ohls, Richard A. Polin, Akhil Maheshwari, Robert D. Christensen
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 8 0 7 6 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 2 5 5 - 2
Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering… Read more
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Request a sales quoteThe thoroughly updated, full-color, 4th Edition of Hematology and Transfusion Medicine:
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Provides a clear management strategy for complications in premature infants resulting from hematologic and immunologic systems that are not yet fully developed, offering guidance based on the most up-to-date understanding of underlying pathophysiology.
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Places emphasis on controversial areas that can entail different approaches.
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Features the most current clinical information throughout, including challenging issues in neonatal hematology such as anemia, transfusions, jaundice, leukocyte counts, and thrombocytopenia.
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Includes new chapters on neonatal transfusion medicine, with in-depth evaluations of fetal and neonatal iron homeostasis and risk factors for iron deficiency, and up-to-date information on improvements in bilirubin assessment and management.
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Utilizes a consistent chapter organization to help you find information quickly and easily, and contains numerous charts, graphs, radiographic images, and photographs throughout.
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Offers the most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Purchase each volume individually, or get the entire 7-volume Neonatology Questions and Controversies set, which includes online access that allows you to search across all titles!
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Gastroenterology and Nutrition
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Hematology and Transfusion Medicine
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Neonatal Hemodynamics
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Infectious Disease, Immunology, and Pharmacology
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Renal, Fluid, and Electrolyte Disorders
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Neurology
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The Newborn Lung
neonatologists, neonatal nurse practitioners, pediatricians
- Cover image
- Title page
- Table of Contents
- Other Volumes in the Neonatology Questions and Controversies Series
- Copyright
- List of Contributors
- Series Foreword
- Preface
- List of Illustrations
- List of Tables
- SECTION 1. Hematology
- 1. Innovations in screening and management of neonatal hyperbilirubinemia
- Introduction
- Eliminating routine blood typing and direct antiglobulin testing for neonates born to blood group O mothers
- Universal screening and the use of TcB determinations (and use of phototherapy skin patches)
- Age-based nomogram for phototherapy initiation based on nearly 400,000 neonates
- ETCOc measurement for those receiving phototherapy to determine hemolytic vs. nonhemolytic hyperbilirubinemia
- Electronic health record add-on app
- Future directions
- References
- 2. The pivotal role of macrophages in the pathogenesis of necrotizing enterocolitis
- Introduction: Necrotizing enterocolitis
- Macrophage ontogeny
- Maintenance of macrophage pools
- Neonatal gut macrophages are yet to develop the inflammatory anergy seen in adults
- Macrophages in the intestinal mucosa and in necrotizing enterocolitis (NEC)
- Mechanistic studies to study the role of gut macrophages in NEC
- References
- 3. Nucleated red blood cells in neonatal medicine
- Introduction
- Erythroid development in the human fetus
- Enucleation of orthochromatic erythroblasts
- Regulating NRBC release from production sites
- Reference ranges for NRBC counts in neonates, according to gestational age
- NRBC in small for gestational age neonates and in neonates following significant birth asphyxia
- NRBC counts in neonates with hemolytic disease
- How long does it take for fetal hypoxia to result in an elevated NRBC count in the blood?
- Implications of finding an elevated NRBC count in a nonneonatal child
- Implications of finding an elevated NRBC count in a neonate
- Summary
- References
- 4. Age-appropriate biology of neonatal neutrophils
- Introduction
- Development
- Functional characteristics of neonatal neutrophils
- Conclusion
- References
- 5. New erythrocyte diagnostic parameters in neonatal medicine
- Introduction
- Flow-cytometric evaluation as an integral part of a modern CBC
- Reticulocyte hemoglobin content
- Fragmented RBC count
- Proportion of erythrocytes that are microcytic or hypochromic
- Summary
- References
- 6. Neonatal iron homeostasis
- Introduction
- In utero iron accretion
- Iron regulation in neonates
- Measures of iron status
- Iron and brain development
- Iron supplementation
- Iron overload
- Transfusions and iron
- Erythropoiesis-stimulating agents
- Conclusions
- References
- 7. Risk factors for iron deficiency in neonates
- Introduction
- Defining the controversies
- Perinatal iron physiology
- Risk factors for congenital, neonatal, and infantile ID
- Sequelae of ID
- Prevention and/or treatment of ID
- Indices of iron status
- Summary
- References
- 8. Using targeted genetic panels to find the causes of neonatal hemolytic anemia
- Definition, etiologies, and implications of neonatal hemolytic anemia
- General diagnostic approach and considerations
- Conclusion
- References
- SECTION 2. Transfusion Medicine
- 9. Erythropoietin and darbepoetin use in the NICU
- Introduction
- Erythropoiesis stimulating agents
- Preterm ESA studies
- Hospital outcomes
- Neurodevelopmental outcomes
- Pharmacokinetics
- Circulating erythrocyte volume
- Side effects
- Cost effectiveness
- Preterm high-dose Epo studies
- Term ESA studies
- Rationale for ESA dosing
- Summary
- References
- 10. NICU transfusion guidelines and strategies to minimize transfusions
- Introduction
- The development of neonatal transfusion guidelines
- Strategies to minimize transfusions
- Strategies to minimize transfusions
- Validation of cord blood samples
- Outcomes
- Implementation
- Stimulate red cell production
- Conclusion
- References
- 11. Neonatal blood banking and transfusion: Current questions and controversies
- Introduction
- Red blood cells
- Platelets
- Plasma (fresh frozen/cryoprecipitate)
- Conclusion
- References
- 12. Recent advances in NICU platelet transfusions
- Introduction
- Platelet transfusions and prevention of bleeding
- Potential mechanisms underlying the effects of platelet transfusions in neonates
- Potential beneficial effects of platelet transfusions
- Implementation of practice change
- References
- 13. Novel approaches to identify NICU patients who would benefit from platelet transfusions
- Introduction
- Bleeding prediction
- Transfusion effect
- Limitations
- References
- 14. Evidence-based guidelines for administering fresh frozen plasma in the NICU
- Introduction
- Data derived from clinical audits and surveys on FFP use in the NICU
- Recommendations derived from clinical studies on the appropriate use of plasma in neonates
- Effect of FFP dose on clotting times
- Implications of hemostasis assessment in therapeutic decision making for FFP administration
- Best evidence-based practice for administering FFP in the NICU
- References
- 15. Pathophysiologic importance of platelets in neonatal necrotizing enterocolitis
- Introduction
- Possible therapeutic interventions for platelet transfusion-related worsening of NEC
- Alternative potential therapies for thrombocytopenia
- Summary
- References
- Index
- No. of pages: 255
- Language: English
- Edition: 4
- Published: August 1, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323880763
- eBook ISBN: 9780323882552
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Robin K Ohls
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