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Neonatology Questions and Controversies: Gastroenterology and Nutrition
- 4th Edition - September 11, 2023
- Editors: Josef Neu, Brenda Poindexter
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 8 7 5 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 7 9 3 9 - 2
Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trust… Read more
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Request a sales quoteDr. Richard Polin’s Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.
The thoroughly updated, full-color, 4th Edition of Gastroenterology and Nutrition:
Provides in-depth clinical overviews of both common and rare neonatal GI and nutritional disorders, offering guidance based on the most up-to-date understanding of underlying pathophysiology.
Places emphasis on controversial areas that can entail different approaches.
Features the most current clinical information throughout, including the dynamic composition of human milk for precision nutrition, how the developmental biology of the GI tract relates to optimizing nutrition for the most vulnerable infants, interactions of the gut with the brain and other organs, associations between the GI tract and nutritional health and disease with individual nutrients, microbes, and metabolites, and more.
Covers rapidly emerging technologies such as artificial intelligence and multiomics for predictive analytics, as well as in augmenting our understanding of mechanisms of pathophysiology.
Discusses how diagnoses such as sepsis, bronchopulmonary dysplasia, and central nervous system disorders relate to a breakdown of homeostasis in the intestinal tract.
Utilizes a consistent chapter organization to help you find information quickly and easily, and contains numerous charts, graphs, radiographic images, and photographs throughout.
Offers the most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Purchase each volume individually, or get the entire 7-volume Neonatology Questions and Controversies set, which includes online access that allows you to search across all titles!
Gastroenterology and Nutrition
Hematology and Transfusion Medicine
Neonatal Hemodynamics
Infectious Disease, Immunology, and Pharmacology
Renal, Fluid, and Electrolyte Disorders
Neurology
The Newborn Lung
neonatologists, neonatal nurse practitioners, pediatricians
- Cover image
- Title page
- Other Volumes in the Neonatology Questions and Controversies Series
- Table of Contents
- Copyright
- Contributors
- Series Foreword
- Preface
- List of Illustrations
- List of Tables
- 1. Maturation of motor function: Clinical implications
- Introduction
- Embryologic aspects of motility development
- Pharyngo-esophageal motility reflexes in human neonates
- Gastrointestinal motility reflexes in human neonates
- Gastric motor functions
- Small intestine motor functions
- Development of colonic motility in human neonates
- Clinical pathophysiological considerations at crib-side management
- Implications and controversies of gut motility in neonatal gastrointestinal therapies
- Summary
- References
- 2. Intestinal mucosal immunity
- Introduction
- Components of the intestinal mucosal immune system
- Factors affecting the fetal intestinal mucosal immune system
- Factors during perinatal and postnatal development affecting the intestinal immune system
- Neonatal immune system: Preterm infants
- Summary
- References
- 3. Microbiome and multiomics of the developing intestine: Nutritional and environmental perturbations
- Antenatal origins of the perinatal microbiome
- After birth: Determinants of the development of the neonatal microbiome
- Mechanisms by which the neonatal/perinatal microbiome influences pathophysiology in preterm neonates: Immune regulation, inflammation, and epigenetic changes
- Leveraging artificial intelligence for multiomics investigation into health and disease: The need for precision medicine
- Summary
- References
- 4. The brain-gut-microbiota axis
- Introduction
- Overview of brain-gut-microbial signaling
- Development of gut-brain-microbial axis
- Early life disruptions of the gut-brain axis
- Functional gastrointestinal disorders
- Maintaining a healthy gut-brain axis
- Summary
- References
- 5. Trophic factors in the neonatal gastrointestinal tract
- Introduction
- The nature of gut growth
- Gut adaptation in the perinatal period
- How soon and how much to feed enterally
- The trophic role of breast milk versus formula
- Key nutrients to provide enterally
- Key gut hormone and growth factors
- Summary
- Acknowledgments
- References
- 6. The liver and cholestasis (treatment and prevention)
- Neonatal cholestasis and parenteral nutrition
- Neonatal cholestasis and intravenous lipid emulsions
- Clinical studies: IV lipid emulsions and cholestasis
- Summary
- References
- 7. Monitoring of feeding tolerance in preterm infants
- Introduction
- Feeding intolerance in preterm infants
- Current clinical assessment of feeding tolerance
- Emerging technologies to monitor feeding tolerance
- Potential role for the analysis of bacterial colonization, microbiota-derived metabolites, and gut hormones
- Summary
- References
- 8. Human milk bioactives and roles in the GI tract
- Introduction
- Ontogeny of intestinal immunity
- Breastfeeding
- Human milk bioactive components
- Proteins and peptides
- Growth factors and hormones in human milk
- Carbohydrates
- Microbiome
- Human milk microbial metabolites
- Human milk extracellular vesicles
- miRNA
- Summary
- References
- 9. Donor milk nutrition for the preterm infant: Current standards, uses, and transitions
- Introduction and historical background
- Evidence-based outcomes related to donor human milk
- Challenges and limitations in donor milk use
- Current state of donor human milk use in the NICU
- Summary
- References
- 10. Different forms of intestinal injury: Moving beyond NEC
- Introduction
- Necrotizing enterocolitis background
- Classic preterm enterocolitis
- Spontaneous intestinal perforation
- Cardiac-induced mesenteric hypoperfusion syndrome
- Food protein–induced enterocolitis syndrome
- General feeding intolerance
- Summary
- References
- 11. Science-based strategies for providing nutrition for high-risk neonates
- Introduction
- Enteral nutrition
- Parenteral nutrition
- Summary
- References
- 12. International perspective: Management of nutrition in preterm infants in settings with limited resources
- Introduction
- Enteral feeding strategies to improve the nutritional status of preterm infants
- Fortification
- Nutritional interventions to facilitate the transitional period
- Pasteurization methods
- Other supplements used in low-resource settings
- Summary
- References
- 13. The future of neonatal nutrition: Further research and investment, new products
- Introduction
- Nutrition during pregnancy and lactation: Where are we now?
- Precision nutrition prepregnancy and during pregnancy and lactation: The future
- Nutrient intake is highly individualized
- Prematurity
- Enhancing the composition of commercial formulas fed to preterm and term infants
- Summary
- References
- 14. GI surgical conditions in the NICU
- Introduction
- Etiology
- Short bowel syndrome incidence
- Short bowel syndrome clinical presentation
- Nutritional management
- Medical management
- Surgical management
- Summary
- References
- 15. Multiomic-based therapeutics: The future
- Introduction
- Individual omics
- Genomics
- Proteomics
- Metabolomics
- Examples of multiomics
- Multiomics in the intestine
- Summary and the future
- Selected references
- Index
- No. of pages: 244
- Language: English
- Edition: 4
- Published: September 11, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323878753
- eBook ISBN: 9780323879392
JN
Josef Neu
Dr. Neu is Professor, Department of Pediatrics, Division of Neonatology; he received his Bachelor of Arts Degree in 1971, at Wisconsin State University, Whitewater, WI. In 1975 he received his Medical Doctorate, University of Wisconsin, Madison, WI. Dr. Neu completed his Pediatrics Residency at John Hopkins Hospital, Baltimore, MD from 1975-1978, 1978-1980 Postdoctoral Fellow in Neonatology, Stanford University Medical Center, Stanford, CA. In 1987 he completed his Sabbatical, Inselspital, at the University of Bern, Switzerland. Dr. Neu has received during his career several honors and awards. He Chairs and is involved on National and International Committees. Dr. Neu is active on several Society Membership, Editorial boards, journal reviewer, Service to the Community, Service to schools. He is well known for his lectures here and aboard. Dr. Neu has received many appointments as Assistant Professor, Director, Division of Neonatology, Milwaukee Children’s Hospital Milwaukee, WI, Associate Professor, and Associate Division Chief for Neonatology, College of Medicine, University of Florida, Director/Neonatology Fellowship Program and Director of Neonatal Intensive Care Unit.
Affiliations and expertise
Professor, Department of Pediatrics, Division of Neonatology, FL, USABP
Brenda Poindexter
Affiliations and expertise
Chief, Division of Neonatology, System Medical Director for Neonatology, Marcus Professor of Pediatrics, Children’s Healthcare of Atlanta and Emory University, Atlanta, Georgia