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Neonatal Pulmonary Hypertension, An Issue of Clinics in Perinatology
- 1st Edition, Volume 51-1 - February 12, 2024
- Editors: Steve Abman, Satyanarayana Lakshminrusimha
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 0 5 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 0 6 - 2
In this issue of Clinics in Perinatology, guest editors Drs. Satyanarayana Lakshminrusimha and Steve Abman bring their considerable expertise to the topic of Neonatal Pulmonary… Read more
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Request a sales quoteIn this issue of Clinics in Perinatology, guest editors Drs. Satyanarayana Lakshminrusimha and Steve Abman bring their considerable expertise to the topic of Neonatal Pulmonary Hypertension. About one in every 1,250 newborns develop neonatal pulmonary hypertension, and about 25% of survivors will have developmental delays, hearing problems, and/or functional disabilities. In this issue, top experts provide updates to the perinatologist on managing this condition to improve patient outcomes.
- Contains 15 relevant, practice-oriented topics including early pulmonary hypertension in preterm neonates; targeted neonatal echocardiography in the management of neonatal pulmonary hypertension; bronchopulmonary dysplasia and pulmonary hypertension; co-morbidities and late outcomes in neonatal pulmonary hypertension; management of PPHN in resource-limited settings; and more.
- Provides in-depth clinical reviews on neonatal pulmonary hypertension, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Perinatologists/Neonatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- CME Accreditation Page
- Forthcoming Issues
- Foreword
- Preface
- Pulmonary Vascular Regulation in the Fetal and Transitional Lung
- Key points
- Introduction
- Pulmonary circulation: structure and function
- Development of the pulmonary vasculature
- Transition at birth
- Preclinical and clinical applications of pulmonary vascular regulation
- Summary
- Pathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension: Preclinical Studies
- Key points
- Pulmonary vascular development
- Persistent pulmonary hypertension of the newborn
- Congenital diaphragmatic hernia
- Bronchopulmonary dysplasia complicated by pulmonary hypertension
- Future directions and research gaps
- Targeted Neonatal Echocardiography in the Management of Neonatal Pulmonary Hypertension
- Key points
- Introduction
- Pathophysiology
- Management approach
- Phenotype-specific framework for management
- Case study 1: acute pulmonary hypertension of arterial (classic) origin
- Case study 2: acute pulmonary hypertension related to excessive pulmonary blood flow
- Summary
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, “Precision-Medicine” Approach
- Key points
- Introduction
- Goals of oxygen therapy
- Studies in older infants, children, and adults
- Summary
- Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension
- Key points
- Introduction
- A history: neonatal pulmonary hypertension physiology and nitric oxide
- Clinical approach to inhaled nitric oxide therapy: who will benefit?
- Dose
- Weaning
- Duration
- Toxicity
- Contraindications
- Supportive management of pulmonary hypertension
- Inhaled nitric oxide beyond early use in near-term and term neonates
- Summary
- Acknowledgments
- Funding
- Targeted Therapies for Neonatal Pulmonary Hypertension: Beyond Nitric Oxide
- Key points
- Introduction
- Summary
- Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension
- Key points
- Introduction
- Terminology
- Epidemiology and risk factors
- Impact of perinatal asphyxia on pulmonary vascular vasoreactivity
- Impact of perinatal asphyxia on myocardial performance
- Phenotypic etiopathologies of acute pulmonary hypertension in hypoxic ischemic encephalopathy
- Hemodynamics of acute pulmonary hypertension in hypoxic ischemic encephalopathy
- Impact of therapeutic hypothermia on acute pulmonary hypertension
- Cardiopulmonary assessment and diagnostic approach to acute pulmonary hypertension in hypoxic ischemic encephalopathy
- Management of acute pulmonary hypertension in neonates with perinatal asphyxia
- Summary
- Congenital Diaphragmatic Hernia: Pulmonary Hypertension and Pulmonary Vascular Disease
- Key points
- Introduction
- Pathophysiology
- Management
- Prognosis—late pulmonary hypertension and cardiorespiratory profile
- Summary
- Early Pulmonary Hypertension in Preterm Infants
- Key points
- Introduction
- Background
- Preterm birth and pulmonary vascular development
- Pulmonary vascular reactivity in fetal life
- Pulmonary hemodynamics during preterm neonatal transition
- Early pulmonary vascular disease in preterm infants
- Prevalence of early pulmonary hypertension
- Risk factors of early pulmonary hypertension
- "Omics" in early pulmonary hypertension of preterm
- Hypoxic respiratory failure
- Clinical features of early pulmonary hypertension
- Diagnostic evaluation
- Management
- Outcomes
- Knowledge gaps and future directions
- Summary
- Author contributions
- Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care
- Key points
- Introduction
- Pathogenesis of pulmonary vascular disease in bronchopulmonary dysplasia
- Selected physiologic aspects of bronchopulmonary dysplasia-pulmonary hypertension
- Diagnostic strategies for bronchopulmonary dysplasia-pulmonary hypertension
- Selected aspects of care
- Associated cardiovascular abnormalities in bronchopulmonary dysplasia-pulmonary hypertension
- Summary
- Pulmonary Hypertension in Developmental Lung Diseases
- Key points
- Background
- Disorders of the FOXF1 gene and cluster
- Disorders of T-box 4 and the fibroblast growth factor 10 pathway
- Developmental lung disease in trisomy 21
- Neonatal presentation of heritable pulmonary vascular diseases
- Differential diagnosis: disorders of the surfactant system and childhood interstitial lung diseases
- The contribution of pathology and genetics in precision diagnosis
- Acute and long-term management
- Summary
- Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings
- Key points
- Introduction
- Epidemiology
- Clinical features
- Management
- Summary
- Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review
- Key points
- Background
- Methods
- Results
- Discussion
- Summary
- Appendix 1. Specific search terms
- Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension
- Key points
- Introduction
- Outcomes
- Summary
- Funding
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 51-1
- Published: February 12, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443184055
- eBook ISBN: 9780443184062
SA
Steve Abman
Affiliations and expertise
Director, Pediatric Heart Lung Center, Co-Director, Pediatric Pulmonary Hypertension Program, Co-Head, Pediatric Task Force, Pulmonary Vascular Research Institute, Director, Ventilator Care Program, Children’s Hospital of Colorado, Founder and Director, Pediatric Pulmonary Hypertension Network, Founder and Executive Board Member, BPD Collaborative President, American Pediatric SocietySL
Satyanarayana Lakshminrusimha
Affiliations and expertise
Professor, Pediatrics, University of California, Davis