Nelson Textbook of Pediatrics, 2-Volume Set

Volume 1
Part I the Field of Pediatrics

1 Overview of Pediatrics

2 Child Health Disparities

3 Global Child Health

4 Quality and Value in Healthcare for Children

5 Safety in Healthcare for Children

6 Ethics in Pediatric Care

7 Complementary Therapies and Integrative Medicine

8 Pediatric Palliative Care

9 Domestic and International Adoption

10 Foster and Kinship Care

11 Medical Evaluation of the Foreign-born Child

12 Cultural Issues in Pediatric Care

13 Maximizing Children’s Health: Screening, Anticipatory Guidance, and Counseling

14 Injury Control

15 Impact of Violence Exposure on Children

16 Child Trafficking for Sex and Labor

17 Abused and Neglected Children

18 Strategies for Health Behavior Change

Part II Growth, Development, and Behavior

19 Developmental and Behavioral Theories

20 Positive Parenting and Support

21 Assessment of Fetal Growth and Development

22 the Newborn

23 the First Year

24 the Second Year

25 the Preschool Years

26 Middle Childhood

27 Assessment of Growth

28 Developmental and Behavioral Surveillance and Screening

29 Child Care

30 Loss, Separation, and Bereavement

31 Sleep Medicine

Part III Behavioral and Psychiatric Disorders

32 Psychosocial Assessment and Psychiatric Diagnostic Evaluation

33 Psychopharmacology

34 Psychotherapy

35 Somatic Symptom and Related Disorders

36 Rumination and Pica

37 Motor Disorders and Habits

38 Anxiety Disorders, Obsessive-compulsive Disorder, and Posttraumatic Stress Disorder

39 Mood Disorders

40 Suicide and Attempted Suicide

41 Eating Disorders

42 Disruptive, Impulse-control, and Conduct Disorders

43 Tantrums and Breath-holding Spells

44 Lying, Stealing, and Truancy

45 Aggression

46 Self-injurious Behavior

47 Childhood Psychoses

48 Delirium

Part IV Learning and Developmental Disorders

49 Neurodevelopmental and Executive Function and Dysfunction

50 Attention-deficit/hyperactivity Disorder

51 Dyslexia

52 Math and Writing Disabilities

53 Language Development and Communication Disorders

54 Augmentative and Alternative Communication

55 Outcomes Among Infants and Children Who Are Deaf/hard of Hearing

56 Developmental Delay and Intellectual Disability

57 Down Syndrome and Other Abnormalities of Chromosome Number

58 Autism Spectrum Disorder

59 Fragile X Syndromes

Part V Nutrition

60 Nutritional Requirements

61 Feeding Healthy Infants, Children, and Adolescents

62 Nutrition, Food Security, and Health

63 Refeeding Syndrome

64 Malnutrition in High-resource Settings

65 Overweight and Obesity

66 Vitamin a Deficiencies and Excess

67 Vitamin B Complex Deficiencies and Excess

68 Vitamin C (Ascorbic Acid) Deficiency and Excess

69 Vitamin D Deficiency (Rickets) and Excess

70 Vitamin E Deficiency

71 Vitamin K Deficiency

72 Micronutrient Mineral Deficiencies

Part VI Fluid and Electrolyte Disorders

73 Electrolyte and Acid-base Disorders

74 Maintenance and Replacement Therapy

75 Deficit Therapy

76 Fluid and Electrolyte Treatment of Specific Disorders

Part VII Emergency Medicine, Critical Care, and Anesthesia

77 Emergency Medical Services for Children

78 Triage of the Acutely Ill Child

79 Pediatric Cardiorespiratory Emergencies and Resuscitation

80 Acute Care of Multiple Trauma

81 Spinal Cord Injuries in Children

82 Neurologic Emergencies and Stabilization

83 Brain Death: Death by Neurologic Criteria

84 Syncope

85 Shock

86 Acute Care of Respiratory Distress and Failure

87 Altitude-associated Illness in Children

88 Drowning and Submersion Injury

89 Burn Injuries

90 Cold Injuries

91 Anesthesia and Perioperative Care

92 Procedural Sedation

93 Pediatric Pain Management

94 Poisoning

Part VIII Human Genetics

95 Genetics in Pediatric Medicine

96 Principles of Human Genetics

97 Patterns of Genetic Transmission

98 Integration of Genetics Into Pediatric Practice

99 Chromosome Disorders

100 Dysmorphology, Phenotyping, and Sequences

101 Signaling Pathway Disorders

102 Chromatin Regulatory Disorders

103 Genetics of Common Disorders

Part IX Metabolic Disorders

104 an Approach to Inborn Errors of Metabolism

105 Defects in Metabolism of Amino Acids

106 Defects in Metabolism of Lipids

107 Defects in Metabolism of Carbohydrates

108 Mitochondrial Disease Diagnosis

109 Mucopolysaccharidoses

110 Disorders of Purine and Pyrimidine Metabolism

111 Hutchinson-gilford Progeria Syndrome (Progeria)

112 the Porphyrias

113 Hypoglycemia

Part X the Fetus and the Neonatal Infant

114 Overview of Morbidity and Mortality

115 the Newborn Infant

116 High-risk Pregnancies

117 the Fetus

118 Fetal Intervention and Surgery

119 the High-risk Infant

120 Transport of the Critically Ill Newborn

121 Clinical Manifestations of Diseases in the Newborn Period

122 Nervous System Disorders

123 Neonatal Resuscitation and Delivery Room Emergencies

124 Transition to Newborn Pulmonary Respiration

125 Apnea

126 Respiratory Distress Syndrome (Hyaline Membrane Disease)

127 Bronchopulmonary Dysplasia

128 Transient Tachypnea of the Newborn

129 Aspiration of Foreign Material (Meconium Aspiration Syndrome, Aspiration Pneumonia)

130 Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation)

131 Diaphragmatic Hernia

132 Pulmonary Air Leaks: Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema, Pneumopericardium

133 Pulmonary Hemorrhage

134 Digestive System Disorders

135 Meconium Ileus, Peritonitis, Intestinal Obstruction, and Gastroschisis

136 Necrotizing Enterocolitis

137 Jaundice and Hyperbilirubinemia in the Newborn

138 Blood Disorders

139 Anemia in the Newborn Infant

140 Hemolytic Disease of the Fetus and Newborn

141 Neonatal Polycythemia

142 Hemorrhage in the Newborn Infant

143 Nonimmune Hydrops

144 the Umbilicus

145 Neonatal Abstinence Syndrome

146 Fetal Alcohol Spectrum Disorder

147 Infants of Diabetic Mothers

148 Epidemiology of Infections

149 Congenital and Perinatal Infections

Part XI Adolescent Medicine

150 Adolescent Physical and Social Development

151 Delivery of Healthcare to Adolescents

152 Transitioning to Adult Care

153 Gender Identity and Transgender Care

154 Gay, Lesbian, and Bisexual Adolescents

155 the Epidemiology of Adolescent Health Problems

156 Violent Behavior

157 Substance Use Disorder

158 the Breast

159 Menstruation-related Disorders

160 Contraception

161 Adolescent Pregnancy

162 Adolescent Sexual Assault

163 Sexually Transmitted Infections

Part XII Immunology
Section 1 Evaluation of the Immune System

164 Orientation to the Consideration of Inborn Errors of Immunity
Section 2 the T-, B-, and Nk-cell Systems

165 T-cell and Combined Deficiencies

166 B-cell and Antibody Deficiencies

167 Natural Killer Cells
Section 3 the Phagocytic System

168 Neutrophils

169 Eosinophils

170 Disorders of Phagocyte Function

171 Leukopenia

172 Leukocytosis
Section 4 Complement System

173 Complement System
Section 5 Immune Dysregulation

174 Immune Dysregulation

175 Defects of Innate Immunity

176 Approaches to Treatment of Primary Immune Deficiency Diseases
Section 6 Hematopoietic Stem Cell Transplantation

177 Principles and Clinical Indications of Hematopoietic Stem Cell Transplantation

178 Hematopoietic Stem Cell Transplantation From Alternative Sources and Donors

179 Graft-versus-host Disease, Rejection, and Venoocclusive Disease

180 Infectious Complications of Hematopoietic Stem Cell Transplantation

181 Late Effects of Hematopoietic Stem Cell Transplantation

Part XIII Allergic Disorders

182 Allergy and the Immunologic Basis of Atopic Disease

183 Diagnosis of Allergic Disease

184 Allergic Rhinitis

185 Childhood Asthma

186 Atopic Dermatitis (Atopic Eczema)

187 Insect Allergy

188 Ocular Allergies

189 Urticaria (Hives) and Angioedema

190 Anaphylaxis

191 Serum Sickness

192 Food Allergy and Adverse Reactions to Foods

193 Adverse and Allergic Reactions to Drugs

Part XIV Rheumatic Diseases of Childhood (Connective Tissue Disease, Collagen Vascular Diseases)

194 Evaluation of Suspected Rheumatic Disease

195 Treatment of Rheumatic Diseases

196 Juvenile Idiopathic Arthritis

197 Ankylosing Spondylitis and Other Spondyloarthritides

198 Reactive and Postinfectious Arthritis

199 Systemic Lupus Erythematosus

200 Juvenile Dermatomyositis

201 Scleroderma and Raynaud Phenomenon

202 Behçet Disease

203 Sjögren Syndrome

204 Hereditary Periodic Fever Syndromes and Other Systemic Autoinflammatory Diseases

205 Interferonopathies

206 Amyloidosis

207 Macrophage Activation Syndrome

208 Kawasaki Disease

209 Sarcoidosis

210 Vasculitis Syndromes

211 Musculoskeletal Pain Syndromes

212 Chronic Overlapping Pain Conditions

213 Miscellaneous Conditions Associated With Arthritis

Part XV Infectious Diseases
Section 1 General Considerations

214 Public Health Approach to Pandemics
Section 2 Preventive Measures

215 Immunization Practices

216 Infection Prevention and Control

217 Childcare and Communicable Diseases

218 Health Advice for Children Traveling Internationally

219 Fever

220 Fever Without a Focus in the Neonate and Young Infant

221 Fever in the Older Child

222 Fever of Unknown Origin

223 Infections in Immunocompromised Persons

224 Infection Associated With Medical Devices
Section 3 Antibiotic Therapy

225 Principles of Antibacterial Therapy

226 Antimicrobial Stewardship
Section 4 Gram-positive Bacterial Infections

227 Staphylococcus

228 Streptococcus Pneumoniae (Pneumococcus)

229 Group a Streptococcus

230 Group B Streptococcus

231 Non–group a or B Streptococci

232 Enterococcus

233 Diphtheria (Corynebacterium Diphtheriae)

234 Listeria Monocytogenes

235 Actinomyces

236 Nocardia
Section 5 Gram-negative Bacterial Infections

237 Neisseria Meningitidis (Meningococcus)

238 Neisseria Gonorrhoeae (Gonococcus)

239 Kingella Kingae

240 Haemophilus Influenzae

241 Chancroid (Haemophilus Ducreyi)

242 Moraxella Catarrhalis

243 Pertussis (Bordetella Pertussis and Bordetella Parapertussis)

244 Salmonella

245 Shigella

246 Escherichia Coli

247 Cholera

248 Campylobacter

249 Yersinia

250 Aeromonas and Plesiomonas

251 Pseudomonas, Burkholderia, and Stenotrophomonas

252 Tularemia (Francisella Tularensis)

253 Brucella

254 Legionella

255 Bartonella
Section 6 Anaerobic Bacterial Infections

256 Botulism (Clostridium Botulinum)

257 Tetanus (Clostridium Tetani)

258 Clostridioides Difficile Infection

259 Other Anaerobic Infections
Section 7 Mycobacterial Infections

260 Principles of Antimycobacterial Therapy

261 Tuberculosis (Mycobacterium Tuberculosis)

262 Hansen Disease (Mycobacterium Leprae)

263 Nontuberculous Mycobacteria
Section 8 Spirochetal Infections

264 Syphilis (Treponema Pallidum)

265 Nonvenereal Treponemal Infections

266 Leptospira

267 Relapsing Fever (Borrelia)

268 Lyme Disease (Borrelia Burgdorferi)
Section 9 Mycoplasmal Infections

269 Mycoplasma Pneumoniae

270 Genital Mycoplasmas (Mycoplasma Hominis, Mycoplasma Genitalium, and Ureaplasma Urealyticum)
Section 10 Chlamydial Infections

271 Chlamydia Pneumoniae

272 Chlamydia Trachomatis

273 Psittacosis (Chlamydia Psittaci)
Section 11 Rickettsial Infections

274 Spotted Fever Group Rickettsioses

275 Scrub Typhus (Orientia Tsutsugamushi)

276 Typhus Group Rickettsioses

277 Ehrlichiosis and Anaplasmosis

278 Q Fever (Coxiella Burnetii)
Section 12 Fungal Infections

279 Principles of Antifungal Therapy

280 Candida

281 Cryptococcus Neoformans and Cryptococcus Gattii

282 Malassezia

283 Aspergillus

284 Histoplasmosis (Histoplasma Capsulatum)

285 Blastomycosis

286 Coccidioidomycosis (Coccidioides Species)

287 Paracoccidioides Brasiliensis

288 Sporotrichosis (Sporothrix Schenckii)

289 Mucormycosis

290 Pneumocystis Jirovecii

291 Other Pathogenic Fungi
Section 13 Viral Infections

292 Principles of Antiviral Therapy

293 Measles

294 Rubella

295 Mumps

296 Polioviruses

297 Nonpolio Enteroviruses

298 Parvoviruses

299 Herpes Simplex Virus

300 Varicella-zoster Virus

301 Epstein-barr Virus

302 Cytomegalovirus

303 Roseola (Human Herpesviruses 6 and 7)

304 Human Herpesvirus 8

305 Influenza Viruses

306 Parainfluenza Viruses

307 Respiratory Syncytial Virus

308 Human Metapneumovirus

309 Adenoviruses

310 Rhinoviruses

311 Coronaviruse

312 Rotaviruses, Caliciviruses, and Astroviruses

313 Human Papillomaviruses

314 Arboviral Infections

315 Dengue Fever, Dengue Hemorrhagic Fever, and Severe Dengue

316 Yellow Fever

317 Ebola and Other Viral Hemorrhagic Fevers

318 Lymphocytic Choriomeningitis Virus

319 Hantavirus Pulmonary Syndrome

320 Rabies

321 Polyomaviruses

322 Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome

323 Human T-cell Leukemia Viruses (1 and 2)

324 Transmissible Spongiform Encephalopathies
Section 14 Antiparasitic Therapy

325 Principles of Antiparasitic Therapy
Section 15 Protozoan Diseases

326 Primary Amebic Meningoencephalitis

327 Amebiasis

328 Giardiasis and Balantidiasis

329 Cryptosporidium, Cystoisospora, Cyclospora, and Microsporidia

330 Trichomoniasis (Trichomonas Vaginalis)

331 Leishmaniasis (Leishmania)

332 African Trypanosomiasis (Sleeping Sickness; Trypanosoma Brucei Complex)

333 American Trypanosomiasis (Chagas Isease; Trypanosoma Cruzi)

334 Malaria (Plasmodium)

335 Babesiosis (Babesia)

336 Toxoplasmosis (Toxoplasma Gondii)
Section 16 Helminthic Diseases

337 Ascariasis (Ascaris Lumbricoides)

338 Hookworms (Necator Americanus and Ancylostoma Spp.)

339 Trichuriasis (Trichuris Trichiura)

340 Enterobiasis (Enterobius Vermicularis)

341 Strongyloidiasis (Strongyloides Stercoralis)

342 Lymphatic Filariasis (Brugia Malayi, Brugia Timori, and Wuchereria Bancrofti)

343 Other Tissue Nematodes

344 Toxocariasis (Visceral and Ocular Larva Migrans)

345 Trichinellosis (Trichinella Spiralis)

346 Schistosomiasis (Schistosoma)

347 Flukes (Liver, Lung, and Intestinal)

348 Adult Tapeworm Infections

349 Cysticercosis

350 Echinococcosis (Echinococcus Granulosus Sensu Lato and Echinococcus Multilocularis)

Volume 2

Part XVI The Digestive System
Section 1 Clinical Manifestations of Gastrointestinal Disease

351 Normal Digestive Tract Phenomena

352 Major Symptoms and Signs of Digestive Tract Disorders
Section 2 the Oral Cavity

353 Development and Developmental Anomalies of the Teeth

354 Disorders of the Oral Cavity Associated With Other Conditions

355 Malocclusion

356 Cleft Lip and Palate

357 Syndromes With Oral Manifestations

358 Dental Caries

359 Periodontal Diseases

360 Dental Trauma

361 Common Lesions of the Oral Soft Tissues

362 Diseases of the Salivary Glands and Jaws

363 Diagnostic Radiology in Dental Assessment
Section 3 the Esophagus

364 Embryology, Anatomy, and Function of the Esophagus

365 Congenital Anomalies

366 Obstructing Disorders of the Esophagus

367 Dysmotility

368 Hiatal Hernia

369 Gastroesophageal Reflux Disease

370 Eosinophilic Esophagitis, Pill Esophagitis, and Infective Esophagitis

371 Esophageal Perforation

372 Esophageal Varices

373 Ingestions
Section 4 Stomach and Intestines

374 Normal Development, Structure, and Function of the Stomach and Intestines

375 Pyloric Stenosis and Other Congenital Anomalies of the Stomach

376 Intestinal Atresia, Stenosis, and Malrotation

377 Intestinal Duplications, Meckel Diverticulum, and Other Remnants of the Omphalomesenteric Duct

378 Motility Disorders and Hirschsprung Disease

379 Ileus, Adhesions, Intussusception, and Closed-loop Obstructions

380 Foreign Bodies and Bezoars

381 Peptic Ulcer Disease in Children

382 Inflammatory Bowel Disease

383 Eosinophilic Gastroenteritis

384 Celiac Disease

385 Disorders of Malabsorption

386 Intestinal Transplantation in Children With Intestinal Failure

387 Acute Gastroenteritis in Children

388 Chronic Diarrhea

389 Disorders of Brain-gut Interaction (Functional Gastrointestinal Disorders)

390 Cyclic Vomiting Syndrome

391 Acute Appendicitis

392 Surgical Conditions of the Anus and Rectum

393 Tumors of the Digestive Tract

394 Inguinal Hernias
Section 5 Exocrine Pancreas

395 Embryology, Anatomy, and Physiology of the Pancreas

396 Pancreatic Function Tests

397 Disorders of the Exocrine Pancreas

398 Treatment of Pancreatic Insufficiency

399 Pancreatitis

400 Pancreatic Fluid Collections

401 Pancreatic Tumors
Section 6 the Liver and Biliary System

402 Morphogenesis of the Liver and Biliary System

403 Manifestations of Liver Disease

404 Cholestasis

405 Metabolic Diseases of the Liver

406 Viral Hepatitis

407 Liver Abscess

408 Liver Disease Associated With Systemic Disorders

409 Mitochondrial Hepatopathies

410 Autoimmune Hepatitis

411 Drug- and Toxin-induced Liver Injury

412 Acute Hepatic Failure

413 Cystic Diseases of the Biliary Tract and Liver

414 Diseases of the Gallbladder

415 Portal Hypertension and Varices

416 Liver Transplantation
Section 7 Peritoneum

417 Peritoneal Malformations

418 Ascites

419 Peritonitis

420 Epigastric Hernia

Part XVII The Respiratory System
Section 1 Development and Function

421 Diagnostic Approach to Respiratory Disease

422 Chronic or Recurrent Respiratory Symptoms

423 Sudden Infant Death Syndrome

424 Brief Resolved Unexplained Events and Other Acute Events in Infants
Section 2 Disorders of the Respiratory Tract

425 Congenital Disorders of the Nose

426 Acquired Disorders of the Nose

427 Nasal Polyps

428 the Common Cold

429 Sinusitis

430 Acute Pharyngitis

431 Tonsils and Adenoids

432 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/abscess

433 Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis)

434 Congenital Anomalies of the Larynx, Trachea, and Bronchi

435 Foreign Bodies in the Airway

436 Laryngotracheal Stenosis and Subglottic Stenosis

437 Bronchomalacia and Tracheomalacia

438 Neoplasms of the Larynx, Trachea, and Bronchi

439 Wheezing, Bronchiolitis, and Bronchitis

440 Plastic Bronchitis

441 Emphysema and Overinflation

442 Α1-antitrypsin Deficiency and Emphysema

443 Other Distal Airway Diseases

444 Congenital Disorders of the Lung

445 Pulmonary Edema

446 Acute Aspiration

447 Chronic Recurrent Aspiration

448 Immune and Inflammatory Lung Disease

449 Community-acquired Pneumonia

450 E-cigarette or Vaping Product Use–associated Lung Injury (Evali)

451 Pleurisy, Pleural Effusions, and Empyema

452 Bronchiectasis

453 Pulmonary Abscess

454 Cystic Fibrosis

455 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome, Kartagener Syndrome)

456 Diffuse Lung Diseases in Childhood

457 Pulmonary Hemosiderosis

458 Pulmonary Embolism, Infarction, and Hemorrhage

459 Atelectasis

460 Pulmonary Tumors

461 Pneumothorax

462 Pneumomediastinum

463 Hydrothorax

464 Hemothorax

465 Chylothorax

466 Bronchopulmonary Dysplasia

467 Skeletal Diseases Influencing Pulmonary Function

468 Chronic Respiratory Insufficiency

Part XVIII The Cardiovascular System
Section 1 Developmental Biology of the Cardiovascular System

469 Cardiac Development

470 the Fetal to Neonatal Circulatory Transition
Section 2 Evaluation of the Cardiovascular System and the Child With a Heart Murmur

471 History and Physical Examination in Cardiac Evaluation

472 Laboratory Cardiac Evaluation
Section 3 Congenital Heart Disease

473 Epidemiology and Genetic Basis of Congenital Heart Disease

474 Evaluation and Screening of the Infant or Child With Congenital Heart Disease

475 Acyanotic Congenital Heart Disease: Left-to-right Shunt Lesions

476 Acyanotic Congenital Heart Disease: Obstructive Lesions

477 Acyanotic Congenital Heart Disease: Regurgitant Lesions

478 Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate With Cyanosis and Respiratory Distress

479 Cyanotic Congenital Heart Disease: Lesions Associated With Decreased Pulmonary Blood Flow

480 Cyanotic Congenital Heart Disease: Lesions Associated With Increased Pulmonary Blood Flow

481 Other Congenital Heart and Vascular Malformations

482 Pulmonary Hypertension

483 General Principles of Treatment of Congenital Heart Disease
Section 4 Cardiac Arrhythmias

484 Disturbances of Rate and Rhythm of the Heart

485 Sudden Death
Section 5 Acquired Heart Disease

486 Infective Endocarditis

487 Rheumatic Heart Disease
Section 6 Diseases of the Myocardium and Pericardium

488 Diseases of the Myocardium

489 Diseases of the Pericardium

490 Tumors of the Heart
Section 7 Cardiac Therapeutics

491 Heart Failure

492 Pediatric Heart and Heart-lung Transplantation
Section 8 Diseases of the Peripheral Vascular System

493 Diseases of the Blood Vessels (Aneurysms and Fistulas)

494 Systemic Hypertension
Part XIX Diseases of the Blood
Section 1 the Hematopoietic System

495 Development of the Hematopoietic System

496 Anemias
Section 2 Anemias of Inadequate Production

497 Congenital Hypoplastic Anemia (Diamond-blackfan Anemia)

498 Pearson Syndrome

499 Acquired Pure Red Blood Cell Anemia

500 Anemia of Chronic Disease and Renal Disease

501 Congenital Dyserythropoietic Anemias

502 Physiologic Anemia of Infancy

503 Megaloblastic Anemias

504 Iron-deficiency Anemia

505 Other Microcytic Anemias
Section 3 Hemolytic Anemias

506 Definitions and Classification of Hemolytic Anemias

507 Hereditary Spherocytosis

508 Hereditary Elliptocytosis, Hereditary Pyropoikilocytosis, and Related Disorders

509 Hereditary Stomatocytosis Syndromes

510 Paroxysmal Nocturnal Hemoglobinuria and Acanthocytosis

511 Hemoglobinopathies

512 Enzymatic Defects

513 Hemolytic Anemias Resulting From Extracellular Factors—immune Hemolytic Anemias

514 Hemolytic Anemias Secondary to Other Extracellular Factors
Section 4 Polycythemia (Erythrocytosis)

515 Polycythemia

516 Nonclonal Polycythemia
Section 5 the Pancytopenias

517 Inherited Bone Marrow Failure Syndromes With Pancytopenia

518 Acquired Pancytopenias
Section 6 Blood Component Transfusions

519 Red Blood Cell Transfusions and Erythropoietin Therapy

520 Platelet Transfusions

521 Neutrophil (Granulocyte) Transfusions

522 Plasma Transfusions

523 Risks of Blood Transfusions
Section 7 Hemorrhagic and Thrombotic Diseases

524 Hemostasis

525 Hereditary Clotting Factor Deficiencies (Bleeding Disorders)

526 Von Willebrand Disease

527 Hereditary Predisposition to Thrombosis

528 Thrombotic Disorders in Children

529 Postneonatal Vitamin K Deficiency

530 Coagulopathy in Liver Disease

531 Acquired Inhibitors of Coagulation

532 Disseminated Intravascular Coagulation

533 Platelet and Blood Vessel Disorders
Section 8 the Spleen

534 Anatomy and Function of the Spleen

535 Splenomegaly

536 Hyposplenism, Splenic Trauma, and Splenectomy
Section 9 the Lymphatic System

537 Anatomy and Function of the Lymphatic System

538 Abnormalities of Lymphatic Vessels

539 Lymphadenopathy

Part XX Cancer and Benign Tumors

540 Epidemiology of Childhood and Adolescent Cancer

541 Molecular and Cellular Biology of Cancer

542 Principles of Cancer Diagnosis

543 Principles of Cancer Treatment

544 the Leukemias

545 Lymphoma

546 Central Nervous System Tumors in Childhood

547 Neuroblastoma

548 Neoplasms of the Kidney

549 Soft Tissue Sarcomas

550 Neoplasms of Bone

551 Retinoblastoma

552 Gonadal and Germ Cell Neoplasms

553 Neoplasms of the Liver

554 Complex Vascular Anomalies

555 Rare Tumors

556 Histiocytosis Syndromes of Childhood

Part XXI Nephrology
Section 1 Glomerular Disease

557 Introduction to Glomerular Diseases
Section 2 Conditions Particularly Associated With Hematuria

558 Clinical Evaluation of the Child With Hematuria

559 Isolated Glomerular Diseases Associated With Recurrent Gross Hematuria

560 Multisystem Disease Associated With Hematuria

561 Tubulointerstitial Disease Associated With Hematuria

562 Vascular Diseases Associated With Hematuria

563 Anatomic Abnormalities Associated With Hematuria

564 Lower Urinary Tract Causes of Hematuria
Section 3 Conditions Particularly Associated With Proteinuria

565 Clinical Evaluation of the Child With Proteinuria

566 Conditions Associated With Proteinuria

567 Nephrotic Syndrome
Section 4 Tubular Disorders

568 Tubular Function

569 Renal Tubular Acidosis

570 Nephrogenic Diabetes Insipidus

571 Inherited Tubular Transport Abnormalities

572 Renal Failure

573 Renal Transplantation

Part XXII Urologic Disorders in Infants and Children

574 Congenital Anomalies and Dysgenesis of the Kidneys

575 Urinary Tract Infections

576 Vesicoureteral Reflux

577 Obstruction of the Urinary Tract

578 Anomalies of the Bladder

579 Neuropathic Bladder

580 Enuresis and Voiding Dysfunction

581 Anomalies of the Penis and Urethra

582 Disorders and Anomalies of the Scrotal Contents

583 Trauma to the Genitourinary Tract

584 Urinary Lithiasis

Part XXIII Gynecologic Problems of Childhood

585 Gynecologic History and Physical Examination

586 Vulvovaginitis

587 Vaginal Bleeding in the Prepubertal Child

588 Breast Health

589 Polycystic Ovary Syndrome and Hirsutism

590 Gynecologic Neoplasms and Prevention Methods for Human Papillomavirus Infections in Adolescents

591 Vulvovaginal and Müllerian Anomalies

592 Gynecologic Care for Adolescents With Special Needs

593 Female Genital Mutilation

Part XXIV the Endocrine System
Section 1 Disorders of the Hypothalamus and Pituitary Gland

594 Hormones of the Hypothalamus and Pituitary

595 Hypopituitarism

596 Diabetes Insipidus

597 Other Abnormalities of Arginine Vasopressin Metabolism and Action

598 Hyperpituitarism

599 Physiology of Puberty

600 Disorders of Pubertal Development
Section 2 Disorders of the Thyroid Gland

601 Thyroid Development and Physiology

602 Disorders of Thyroxine-binding Globulin

603 Hypothyroidism

604 Thyroiditis

605 Goiter

606 Thyrotoxicosis

607 Carcinoma of the Thyroid

608 Autoimmune Polyglandular Syndromes

609 Multiple Endocrine Neoplasia Syndromes
Section 3 Disorders of the Parathyroid Gland

610 Hormones and Peptides of Calcium Homeostasis and Bone Metabolism

611 Hypoparathyroidism

612 Pseudohypoparathyroidism

613 Hyperparathyroidism
Section 4 Disorders of the Adrenal Gland

614 Physiology of the Adrenal Gland

615 Adrenocortical Insufficiency and Altered Sensitivity to Corticosteroids

616 Congenital Adrenal Hyperplasia and Related Disorders

617 Adrenocortical Tumors and Masses

618 Virilizing and Feminizing Adrenal Tumors

619 Cushing Syndrome

620 Primary Aldosteronism

621 Pheochromocytoma
Section 5 Disorders of the Gonads

622 Development and Function of the Gonads

623 Hypofunction of the Testes

624 Pseudoprecocity Resulting From Tumors of the Testes

625 Gynecomastia

626 Hypofunction of the Ovaries

627 Pseudoprecocity Resulting From Lesions of the Ovary

628 Disorders of Sex Development
Section 6 Diabetes Mellitus in Children

629 Diabetes Mellitus

Part XXV the Nervous System

630 Neurologic Evaluation

631 Congenital Anomalies of the Central Nervous System

632 Deformational Plagiocephaly

633 Seizures in Childhood

634 Conditions That Mimic Seizures

635 Headaches

636 Neurocutaneous Syndromes

637 Movement Disorders

638 Encephalopathies

639 Neurodegenerative Disorders of Childhood

640 Demyelinating Disorders of the Central Nervous System

641 Pediatric Stroke

642 Central Nervous System Vasculitis

643 Central Nervous System Infections

644 Brain Abscess

645 Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)

646 Spinal Cord Disorders

Part XXVI Neuromuscular Disorders

647 Evaluation and Investigation of Neuromuscular Disorders

648 Developmental Disorders of Muscle

649 Muscular Dystrophies

650 Endocrine and Toxic Myopathies

651 Metabolic Myopathies and Channelopathies

652 Disorders of Neuromuscular Transmission and of Motor Neurons

653 Hereditary Motor-sensory Neuropathies

654 Toxic Neuropathies

655 Autonomic Neuropathies

656 Guillain-barré Syndrome

657 Bell Palsy

Part XXVII Disorders of the Eye

658 Growth and Development of the Eye

659 Examination of the Eye

660 Abnormalities of Refraction and Accommodation

661 Disorders of Vision

662 Abnormalities of Pupil and Iris

663 Disorders of Eye Movement and Alignment

664 Abnormalities of the Lids

665 Disorders of the Lacrimal System

666 Disorders of the Conjunctiva

667 Abnormalities of the Cornea

668 Abnormalities of the Lens

669 Disorders of the Uveal Tract

670 Disorders of the Retina and Vitreous

671 Abnormalities of the Optic Nerve

672 Childhood Glaucoma

673 Orbital Abnormalities

674 Orbital Infections

675 Injuries to the Eye

Part XXVIII The Ear

676 General Considerations and Evaluation of the Ear

677 Hearing Loss

678 Congenital Malformations of the Ear

679 External Otitis (Otitis Externa)

680 Otitis Media

681 Acute Mastoiditis

682 the Inner Ear and Diseases of the Bony Labyrinth

683 Traumatic Injuries of the Ear and Temporal Bone

684 Tumors of the Ear and Temporal Bone

Part XXIX The Skin

685 Morphology of the Skin

686 Dermatologic Evaluation of the Patient

687 Principles of Dermatologic Therapy

688 Dermatologic Diseases of the Neonate

689 Cutaneous Defects

690 Ectodermal Dysplasias

691 Vascular Anomalies

692 Cutaneous Nevi

693 Hyperpigmented Lesions

694 Hypopigmented Lesions

695 Vesiculobullous Disorders

696 Eczematous Disorders

697 Photosensitivity

698 Diseases of the Epidermis

699 Disorders of Keratinization

700 Diseases of the Dermis

701 Diseases of Subcutaneous Tissue

702 Disorders of the Sweat Glands

703 Disorders of Hair

704 Disorders of the Nails

705 Disorders of the Mucous Membranes

706 Cutaneous Bacterial Infections

707 Cutaneous Fungal Infections

708 Cutaneous Viral Infections

709 Arthropod Bites and Infestations

710 Acne

711 Tumors of the Skin

712 Nutritional Dermatoses

Part XXX Bone and Joint Disorders
Section 1 Orthopedic Problems

713 Orthopedic Growth and Development

714 Orthopedic Evaluation of the Child

715 the Foot and Toes

716 Torsional and Angular Deformities of the Limb

717 Leg-length Discrepancy

718 the Knee

719 the Hip

720 the Spine

721 the Neck

722 the Upper Limb

723 Arthrogryposis

724 Common Fractures

725 Osteomyelitis

726 Septic Arthritis
Section 2 Sports Medicine

727 Prevention of Injuries

728 Management of Musculoskeletal Injury

729 Sports-related Traumatic Brain Injury (Concussion)

730 Cervical Spine Injuries

731 Heat Injuries

732 Nutrition and Endocrine Conditions in Athletes

733 Performance-enhancing Aids

734 Specific Sports and Associated Injuries
Section 3 the Skeletal Dysplasias

735 General Considerations in Skeletal Dysplasias

736 Disorders Involving Cartilage Matrix Proteins

737 Disorders Involving Transmembrane Receptors

738 Disorders Involving Ion Transporters

739 Disorders Involving Transcription Factors

740 Osteopetrosis and Other Disorders Involving Defective Bone Resorption

741 Other Inherited Disorders of Skeletal Development

742 Osteogenesis Imperfecta
Section 4 Connective Tissue Disorders

743 Marfan Syndrome

744 Ehlers-danlos Syndrome

745 Cutis Laxa
Section 5 Metabolic Bone Disease

746 Bone Structure, Growth, and Hormonal Regulation

747 Hypophosphatasia

748 Hyperphosphatasia

749 Osteoporosis

Part XXXI Rehabilitation Medicine

750 Rehabilitation for Traumatic Brain Injury

751 Spinal Cord Injury and Autonomic Dysreflexia Management

752 Spasticity

753 Birth Brachial Plexus Palsy

754 Meningomyelocele (Spina Bifida)

755 Upper and Lower Extremity Assistive Devices

756 Health and Wellness for Children With Disabilities

Part XXXII Environmental Health

757 Overview of Environmental Health and Children

758 Biologic Effects of Ionizing Radiation on Children

759 Chemical Pollutants

760 Heavy Metal Intoxication

761 Lead Poisoning

762 Nonbacterial Food Poisoning

763 Biological and Chemical Terrorism

764 Mass Psychogenic Illness

765 Animal and Human Bites

766 Rat Bite Fever

767 Mpox (Monkeypox)

768 Envenomations

Part XXXIII Laboratory Medicine (Available in Digital Format Only)

769 Laboratory Testing in Infants and Children

770 Reference Intervals for Laboratory Tests and Procedures