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Elsevier

Necroptosis

A Programmed Cell Death Machinery in Human Health

  • 1st Edition - December 1, 2026
  • Latest edition
  • Editor: Pratyusha Mandal
  • Language: English

Necroptosis: A Programmed Cell Death Machinery in Human Health provides a comprehensive review of the evolving concepts of programmed cell death (PCD) machinery. The book traces th… Read more

Description

Necroptosis: A Programmed Cell Death Machinery in Human Health provides a comprehensive review of the evolving concepts of programmed cell death (PCD) machinery. The book traces the evolutionary origin of necroptosis, necroptotic proteins, and how the proteins contribute to necroptosis and other cell death pathways. It clarifies necroptosis as more than merely an alternate to extrinsic apoptosis but explores it as an inflammatory form of cell death interconnected with multiple death signaling that ultimately dictates physiological outcome. Coverage summarizes the role of the death pathway and proteins in mammalian health and disease as well as key diseases where they play recognized contributing roles. The involvement of necroptosis in pulmonary diseases including activation during SARS-CoV2 infection is covered along with other gastroenteric diseases, cancer, and aging. Beyond conveying clinical knowledge, these topics will be of strong research interest to the biomedical bench scientist.

Key features

  • Explains programmed cell death machinery as ubiquitous in all eukaryotes and as fundamentally related to health and disease in mammals
  • Elucidates necroptosis as a factor of tissue injury in high relevant human diseases including COVID-19
  • Explains the suppression of necroptosis and other cell death pathways as a key modus operandi by pathogens

Readership

Principal investigators with research laboratories, research trainees, Undergraduate curriculum instructors teaching premed courses, medical students with infectious disease/pulmonary/mucosal immunology focus, Life science students in bachelors or masters courses, and non-research track practicing physicians

Table of contents

1. Introduction

2. Evolution of programmed cell death pathways with focus on necroptosis

3. Necroptosis, necroptotic proteins and regulation of necroptotic signaling, as well as contribution in important physiological signaling including development

4. Cell death, necroptosis, and acute inflammatory Disease

5. Cell death, necroptosis and chronic inflammatory diseases:

6. Necroptosis and Tumor

7. Necroptosis and infections

8. DNA viruses and cell death

9. RNA viruses and cell death

10. Bacteria and cell death

11. Cell death and necroptosis during emerging infections

12. Cell death proteins in death-independent inflammation

13. Future Directions

Product details

  • Edition: 1
  • Latest edition
  • Published: December 1, 2026
  • Language: English

About the editor

PM

Pratyusha Mandal

Pratyusha Mandal, PhD is an adjunct professor in the Department of Microbiology and Immunology at Emory University. Her main research areas focus on mucosal inflammatory diseases including acute, as well as chronic pulmonary and intestinal pathologies. She is the recipient of the 2021-2023 Cystic Fibrosis Foundation Pilot and Feasibility Award, won the 2021-1st Position in Emory Winship Discovery and Developmental Therapeutics competition. She is a member of the American Society for Microbiology, American Society for Virology, and was a participant in the Women in Science Program at Purdue University from 2006-2012 as well as a board member of the National Postdoctoral Association from 2015-2018.
Affiliations and expertise
Professor, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, USA