Navigating Tuberculosis
Insights into Host-Pathogen Protein Interactions
- 1st Edition - August 12, 2026
- Latest edition
- Editors: Mohammad Shariq, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham
- Language: English
Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions, the latest release in the Foundations and Frontiers in Enzymology series, explores the interactions… Read more
Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions, the latest release in the Foundations and Frontiers in Enzymology series, explores the interactions between host proteins and the tuberculosis pathogen, Mycobacterium tuberculosis (M. tb), emphasizing their roles in virulence and pathogenesis. The book delves into mechanistic insights, focusing on their roles in modulating innate and adaptive immunity and understanding TB pathomechanisms by elucidating the interplay between host defenses and M. tb infection. It provides a foundation for developing targeted mitigation strategies and discusses key regulatory pathways and protein factors involved in host-pathogen interactions, informing the design and implementation of innovative approaches to combat TB.
This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035 by addressing the need for up-to-date information on host-pathogen interactions in tuberculosis and incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb.
This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035 by addressing the need for up-to-date information on host-pathogen interactions in tuberculosis and incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb.
- Provides comprehensive insights into the complex interactions between host proteins and the tuberculosis pathogen, revealing essential aspects of tuberculosis pathophysiology
- Investigates the latest discoveries and breakthroughs in the field to uncover innovative approaches for diagnosing and treating tuberculosis, including novel therapeutic targets
- Offers a multidisciplinary perspective that combines insights from microbiology, immunology, biochemistry, and molecular biology
- Highlights cutting-edge research on key host and pathogen proteins involved in tuberculosis, offering detailed discussions on their roles in modulating innate and adaptive immunity
- Explores host-mediated inhibition strategies targeting Mycobacterium tuberculosis, paving the way for the development of novel therapeutic interventions to bolster host defenses against TB
Basic Research Scientists: Researchers actively engaged in studying the intricate relationship between Mycobacterium tuberculosis (M. tb) and the human host, focusing on molecular and cellular levels; Microbiologists: Scientists specializing in microbiology who are interested in understanding the mechanisms of M. tb infection and its interaction with host cells; Immunologists: Researchers studying the immune response to M. tb infection, including the roles of innate and adaptive immunity in tuberculosis pathogenesis; Molecular Biologists: Scientists investigating the molecular mechanisms underlying host-pathogen interactions, protein functions, and signaling pathways in tuberculosis; Infectious Disease Researchers: Researchers focused on infectious diseases, particularly those studying tuberculosis, its pathogenesis, and potential therapeutic interventions; Biochemists: Scientists exploring the biochemical aspects of protein interactions, post-translational modifications, and proteostasis in the context of M. tb infection; Graduate and Postdoctoral Students: Advanced students and postdoctoral researchers working on tuberculosis, host-pathogen interactions, and related fields who seek comprehensive and up-to-date research information; Public Health Researchers: Professionals involved in public health research who are interested in the molecular and cellular mechanisms of tuberculosis to inform better disease control and prevention strategies.
1. Mechanisms of Mycobacterium tuberculosis Virulence: The esx1 Locus and Host Countermeasures
2. Host Adaptation Strategies of Mycobacterium tuberculosis: A Molecular Perspective
3. Unravelling M. tuberculosis Manipulation of Host Immunity: Insights from Functional Genomics and Proteomics
4. Macrophages: Frontline Warriors Against Mycobacterium tuberculosis Invasion
5. Unravelling Mycobacterium tuberculosis Pathogenesis: Insights into PE/PPE Proteins from a Molecular Viewpoint
6. Host-Pathogen Dynamics in Mycobacterium tuberculosis: The Impact of PE/PPE Proteins on Innate and Adaptive Immunity
7. PE/PPE Proteins in Mycobacterium tuberculosis: Key Regulators of Apoptosis and Pathogenic Outcomes
8. Autophagy and Mycobacterium tuberculosis: Host Defense Mechanisms Versus Pathogen Evasion
9. Mechanisms of Phagosomal Damage Detection and Response to Mycobacterium tuberculosis: Repair, Autophagy, and Biogenesis
10. Programmed Cell Death During Mycobacterium tuberculosis Infection: The Roles of Pyroptosis and Necroptosis in Host Defense
11. Metabolic Repurposing in Mycobacterium-Infected Macrophages: A Strategy for Enhanced Virulence and Survival
12. Type I Interferons in Tuberculosis: Friend or Foe?
13. Type II Interferon in Tuberculosis: Orchestrating Infection Outcome through Mechanistic Insights
14. Cell Envelope Dynamics in Mycobacterium tuberculosis: Implications for Tuberculosis Pathogenesis and Host-Pathogen Interaction
15. Combatting Tuberculosis Drug Resistance: Effective Strategies for Overcoming Challenges
16. Beyond Treatment: Strategies for Mitigating Long-Term Morbidity and Mortality in Tuberculosis Survivors
2. Host Adaptation Strategies of Mycobacterium tuberculosis: A Molecular Perspective
3. Unravelling M. tuberculosis Manipulation of Host Immunity: Insights from Functional Genomics and Proteomics
4. Macrophages: Frontline Warriors Against Mycobacterium tuberculosis Invasion
5. Unravelling Mycobacterium tuberculosis Pathogenesis: Insights into PE/PPE Proteins from a Molecular Viewpoint
6. Host-Pathogen Dynamics in Mycobacterium tuberculosis: The Impact of PE/PPE Proteins on Innate and Adaptive Immunity
7. PE/PPE Proteins in Mycobacterium tuberculosis: Key Regulators of Apoptosis and Pathogenic Outcomes
8. Autophagy and Mycobacterium tuberculosis: Host Defense Mechanisms Versus Pathogen Evasion
9. Mechanisms of Phagosomal Damage Detection and Response to Mycobacterium tuberculosis: Repair, Autophagy, and Biogenesis
10. Programmed Cell Death During Mycobacterium tuberculosis Infection: The Roles of Pyroptosis and Necroptosis in Host Defense
11. Metabolic Repurposing in Mycobacterium-Infected Macrophages: A Strategy for Enhanced Virulence and Survival
12. Type I Interferons in Tuberculosis: Friend or Foe?
13. Type II Interferon in Tuberculosis: Orchestrating Infection Outcome through Mechanistic Insights
14. Cell Envelope Dynamics in Mycobacterium tuberculosis: Implications for Tuberculosis Pathogenesis and Host-Pathogen Interaction
15. Combatting Tuberculosis Drug Resistance: Effective Strategies for Overcoming Challenges
16. Beyond Treatment: Strategies for Mitigating Long-Term Morbidity and Mortality in Tuberculosis Survivors
- Edition: 1
- Latest edition
- Published: August 12, 2026
- Language: English
MS
Mohammad Shariq
Dr. Mohd Shariq, Ph.D., obtained his doctoral degree in Biological Sciences from Jawaharlal Nehru University, India, focusing on Cellular and Molecular Biology of Infectious Diseases. He has authored 30 peer-reviewed articles in prestigious journals like Autophagy, Journal of Medical Virology, European Respiratory Review, and Frontiers in Immunology. Dr. Shariq has mentored numerous students in independent research projects and is joining GITAM University, Hyderabad, as an Assistant Professor, bringing extensive expertise in Cellular and Molecular Biology and Microbiology. Previously, as a Senior Scientist and Group Leader at QuantLase Imaging Laboratory, he published four research articles in reputed international journals such as Cellular and Molecular Biology Letters (Springer). His research on host-pathogen interactions in tuberculosis and the role of M. tb proteins in inflammation and autophagy regulation has significantly advanced the understanding of TB pathomechanisms. Additionally, his insights into drug resistance mechanisms in Candida albicans and Helicobacter pylori infections have enriched our understanding of microbial pathogenesis. Dr. Shariq serves as an acting reviewer for esteemed journals like Frontiers, Scientific Reports, and others, and acts as a review editor for Gut Pathogens and Frontiers.
Affiliations and expertise
GITAM University, IndiaSH
Seyed Ehtesham Hasnain
Professor Seyed E. Hasnain is a distinguished figure in tuberculosis research, specializing in infection biology and functional epidemiology. His groundbreaking contributions have earned him international recognition and a multitude of prestigious awards, including the Robert Koch Fellowship in Berlin, Membership of the American Academy of Microbiology, and induction into the German National Academy of Sciences-Leopoldina. He is also a Fellow of TWAS (Italy) and all major Indian Science Academies (FNA/FASc/FNASc). Prof. Hasnain's accolades further include the Alexander von Humboldt Research Award, the Shanti Swarup Bhatnagar Prize, the GD Birla Award, and the JC Bose Fellowship. With a distinguished career spanning decades, Prof. Hasnain has served in various esteemed roles. Notably, he was a member of the Science Advisory Council to the Prime Minister of India for two terms (2004-2014), the inaugural Director of the Centre for DNA Fingerprinting and Diagnostics in Hyderabad, and subsequently the Vice-Chancellor of the University of Hyderabad from 2005 to 2011, and the Vice-Chancellor of Jamia Hamdard University (2016-2021). He also held the esteemed position of invited Prof. at IIT-Delhi from 2011 to 2019. Presently, Prof. Hasnain serves as a National Science Chair at the Indian Institute of Technology, Delhi (IIT-D), and is also a Distinguished Professor at Sharda University.
Affiliations and expertise
School of Basic Sciences and Research, Sharda University, IndiaNE
Nasreen Zafar Ehtesham
Professor Nasreen Z. Ehtesham completed her Master's degree at Aligarh Muslim University, Aligarh, and pursued graduate training at the University of Alberta, Edmonton, Canada. She earned her Ph.D. from the National Institute of Immunology, New Delhi, in 1991, followed by a Rockefeller Postdoc Fellowship at the ICGEB. As Deputy Director at the National Institute of Nutrition, Hyderabad, her research group focused on nutrition and inflammation biology, particularly in elucidating the link between pathogenesis, inflammation, and stress response using the Mycobacterium tuberculosis infection model. Prof. Nasreen Ehtesham has contributed extensively to decision-making bodies of the Health Ministry and S&T Ministry and has published over 100 research papers in esteemed journals like PNAS, garnering over 5000 citations. She served as Director-in-Charge at the ICMR National Institute of Pathology, New Delhi, and is recognized as an Elected Fellow of the Indian National Science Academy, the National Academy of Sciences, India, and the Andhra Pradesh Akademi of Sciences, India. She has received numerous awards, including the ICMR Kshanika Award in 2014 and the Outstanding Work of the Year Award from NII, New Delhi, in 1990. Prof. Nasreen Ehtesham is a member of various professional societies and serves on the editorial boards of several esteemed journals, including Molecular and Cellular Biochemistry (Springer) and Gut Pathogens (BioMed Central). Presently, Prof. Nasreen Ehtesham is a Distinguished Professors at Sharda University.
Affiliations and expertise
School of Basic Sciences and Research, Sharda University, India