Natural Plant Products in Inflammatory Bowel Diseases

Preventive and Therapeutic Potential

1st Edition - March 17, 2023
Editors: Roberto de Paula do Nascimento, Ana Paula da Fonseca Machado, Alba Rodriguez-Nogales, Raquel Franco Leal, Carlos Augusto Real Martinez, Julio Galvez, Mario Roberto Maróstica Junior
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 1 1 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 1 2 - 4

Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of… Read more

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Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of investigation and which have strong evidence of their effects in inflammatory bowel diseases, have been tested in clinical trials, and have received approval to be officially used. In addition to providing information regarding the research with natural products in inflammatory bowel diseases, this reference will also highlight the molecular mechanisms behind the effects of natural products in inflammatory bowel diseases with the aid of figures, video animations and dynamic tables.

Compiled from research group members from different parts of the world and specialized in inflammatory bowel diseases and related topics, this important reference will be useful to health professionals, researchers, professors, and industry managers as it provides helpful information on the subject, with the potential to inspire health care, relevant research and product innovation.

Cover
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Introduction: History of inflammatory bowel diseases and relevance of natural plant products
Abstract
Acknowledgments
1: History of inflammatory bowel diseases
References
Chapter 2: Pathogenesis: Crohn’s disease and ulcerative colitis
Abstract
Acknowledgments
1: Etiology
2: Clinical, histological, and physiological implications
3: In vitro and animal models
4: Conclusions and future perspectives
References
Chapter 3: Conventional treatment and new drugs
Abstract
1: Introduction
2: 5-Aminosalicylic acid compounds
3: Immunomodulators
4: Corticosteroids
5: Cyclosporine
6: Antibiotics
7: Monoclonal antibodies therapy
8: Small molecules and new therapeutics options
9: New perspectives
10: Conclusion
References
Chapter 4: Disease risk and inflammation-associated diets
Abstract
Acknowledgments
1: Introduction
2: Western diet
3: Mediterranean diet
4: Diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols
5: Plant-based diet
6: Paleolithic diet
7: Conclusion
References
Chapter 5: Fruits
Abstract
1: Introduction
2: Fruits on inflammatory bowel diseases
3: Concluding remarks
References
Chapter 6: Cereal grains and vegetables
Abstract
Acknowledgments
1: Introduction
2: Cereal grains
3: Vegetables
4: Mixtures containing cereal grains and/or vegetables
5: Conclusion
References
Chapter 7: Plant life-associated natural products: Algae and mushrooms
Abstract
Acknowledgments
1: Introduction
2: Algae
3: Mushrooms
4: Conclusions
References
Chapter 8: Vegetable oils and oilseeds
Abstract
1: Introduction
2: Triglycerides and fatty acids
3: Unsaponifiable fraction
4: Vegetable oils and oil seeds in inflammatory bowel diseases
5: Conclusions
References
Chapter 9: Fermented foods, prebiotics, and probiotics
Abstract
1: Introduction
2: Fermented foods
3: Prebiotics
4: Probiotics
5: Conclusion
References
Chapter 10: Medicinal herbs and teas
Abstract
1: Introduction
2: Aloe (Aloe vera)
3: Salai (Boswellia serrata)
4: King of bitters (Andrographis paniculata)
5: Wormwood (Artemisia absinthium)
6: Marijuana (Cannabis sativa)
7: Turmeric (Curcuma longa)
8: St. John’s wort (Hypericum perforatum)
9: Tea plant (Camellia sinensis)
10: Ginger (Zingiber officinale)
11: Garcinia (Garcinia spp.)
12: Japanese apricot (Prunus mume)
13: Wild thyme (Thymus serpyllum)
14: Ginseng (Panax spp.)
15: Moringa (Moringa oleífera)
16: Tormentil (Potentilla erecta)
17: Wheat (Triticum aestivum)
18: Hawthorn (Crataegus oxyacantha)
19: Plant extracts combinations
20: Conclusion
References
Chapter 11: Isolated bioactive compounds
Abstract
1: Introduction
2: Flavonoids
3: Alkaloids
4: Coumarins
5: Curcuminoids
6: Phytosterols
7: Saponins
8: Stilbenes
9: Tannins
10: Terpenes
11: Conclusion
References
Chapter 12: Encapsulating products
Abstract
Acknowledgments
1: Introduction
2: Application of natural product delivery systems in IBD
3: Conclusions
References
Chapter 13: Food industry by-products
Abstract
Acknowledgments
1: Introduction
2: Application of plant by-products in IBD
3: Conclusion
References
Chapter 14: Natural products in conditions associated with inflammatory bowel diseases: Extraintestinal manifestations
Abstract
1: Introduction
2: Natural products in extraintestinal manifestations of IBD
3: Conclusion
References
Chapter 15: Natural products in conditions associated with inflammatory bowel diseases: Colorectal cancer, diversion colitis, and obesity
Abstract
1: Introduction
2: Colorectal cancer
3: Diversion colitis
4: Obesity
5: Conclusions
References
Chapter 16: Conclusion: Future directions
Abstract
Acknowledgments
1: Conclusions and future perspectives
References
Index

Roberto de Paula do Nascimento

More than 10 years of experience with animal experimentation. Roberto's research has been mainly focused on natural plant products against inflammatory bowel diseases and colorectal cancer, with special attention to the potential benefits of native Brazilian fruits. Acts mainly on the following themes: animal models, native Brazilian berries, bioactive compounds, inflammatory bowel diseases, and colorectal cancer.

Affiliations and expertise

Researcher, University of Campinas, Brazil

Ana Paula da Fonseca Machado

More than 10 years of experience with the manipulation of natural plant products and extracts. Acts mainly on the following themes: processes with pressurized fluids, extraction and encapsulation of bioactive compounds, use of agro-industrial residues, and preventive and complementary therapies for inflammatory bowel diseases.

Affiliations and expertise

Researcher, Federal University of Grande Dourados, Brazil

Alba Rodriguez-Nogales

In 2017, she obtained a postdoctoral contract (Ministry of Science and Innovation, Spain) at the Universidad de Granada (UGR). Postdoctoral stay at the Gentofte Regional Hospital in Copenhagen (Denmark, 2019). Throughout her research career, she has participated in numerous national and international research projects, being investigator principal and coordinator of two of them. Awards: Best Thesis in the 2015 "Modesto Laza Palacios" from the Illustrious Association of Pharmacists of Malaga and Extraordinary Doctoral Award in health sciences area, granted by the Universidad de Granada (2018). Currently, she is an assistant professor at Universidad de Granada and her research has mainly focused on the study of the potential therapeutic effects of different compounds (probiotics, prebiotics, antibiotics, or plant extracts), as well as the search for new biomarkers and targets that can improve the diagnosis and prognosis of several inflammatory conditions, including inflammatory bowel diseases.

Affiliations and expertise

Researcher, Universidad de Granada, Spain

Raquel Franco Leal

Currently is an Associate Professor at the University of Campinas (UNICAMP), Brazil. Titular Member of the Brazilian Society of Coloproctology. Member of the Brazilian Federation of Gastroenterology, of the International Society of University Colon and Rectal Surgeons, and an honorary member of the Brazilian Association of Ulcerative Colitis and Crohn's Disease. Member of the Study Group on Inflammatory Bowel Disease in Brazil, European Crohn's and Colitis Organization, and Pan American Crohn's Colitis Organization. Since 2005, Raquel has been doing studies associated with inflammatory bowel diseases.

Affiliations and expertise

Associate Professor, University of Campinas, Brazil

Carlos Augusto Real Martinez

Currently an Associate Professor at the University of Campinas (UNICAMP), Brazil. Titular Member of the Latin American Society of Coloproctology, Brazilian College of Surgeons, Brazilian Society of Coloproctology, Brazilian College of Digestive Surgery, and Brazilian Society for the Development of Research in Surgery. Member of the International Society of University Colorectal Surgeons and the Brazilian Society of Laparoscopic Surgery. Since 2006, Dr. Martinez has been doing experimental studies with inflammatory bowel diseases.

Affiliations and expertise

Associate Professor, São Francisco University, Brazil

Julio Galvez

Currently is a Full Professor at the Universidad de Granada (UGR), Spain. Member of the Research Group "Pharmacology of Natural Products" at UGR (CTS-164), which is involved in the evaluation of active natural compounds on intestinal inflammatory conditions and metabolic syndrome. Participation in more than 20 research projects with public funding and 25 projects with private funding. Julio's activity is reflected in more than 130 manuscripts in the field of Pharmacology, Gastroenterology, and Nutrition. Member of CIBER-EHD (ISCIII) and coordinator of the area focused on Precision Medicine in the Institute ibs.GRANADA.

Affiliations and expertise

Full Professor, Universidad de Granada, Spain

Mario Roberto Maróstica Junior

Currently is an Associate Professor at the University of Campinas (UNICAMP), Brazil. He received his Ph.D. stay at Leibniz Universitat Hannover, Germany, in 2004 and a Research stay at Lund University, Sweden, in 2009. Since 2010, Mario has been doing experimental studies with natural products in inflammatory bowel diseases and obesity.

Affiliations and expertise

Associate Professor, University of Campinas, Brazil