Nanotechnology Methods for Neurological Diseases and Brain Tumors
Drug Delivery across the Blood–Brain Barrier
- 1st Edition - July 14, 2017
- Editors: Yasemin Gürsoy Özdemir, Sibel Bozdag Pehlivan, Emine Sekerdag
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 3 7 9 6 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 3 8 0 0 - 0
Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategie… Read more
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Request a sales quoteNanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier.
The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery.
In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.
- Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases
- Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier
- Written in a language that makes it easy to understand nanotechnology drug delivery techniques
- Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors
1.1. Anatomy and physiology of the BBB
1.2. Drug transport and drug metabolism at BBB
1.2.1. Genomics and proteomics of BBB
1.2.2. Transporter systems of BBB and microdialysis
1.2.3. PK/PD in brain drug delivery
2. Nose-to-brain drug delivery
2.1. Nasal physiology and drug administration
2.2. Challenges of the noise-to-brain route
3. Nanoscience in targeted brain drug delivery
3.1. Importance and application of nanotechnology-based brain drug delivery
3.1.1. Nanoparticles
3.1.2. Liposomes
3.1.3. Dendrimers
3.1.4. Carbon nanotubes
3.2. Neurotoxicity
3.3. Clinical considerations
3.4. Ethical and regulatory issues
4. Brain targeted experimental models
4.1. In vitro CNS models
4.2. In vivo and in situ animal models
4.3. PET
5. Targeted treatment strategies for neurological diseases
5.1. Alzheimer’s Disease
5.2. Parkinson’s Disease
5.3. Stroke
6. CNS tumor targeting
Future outlook
- No. of pages: 378
- Language: English
- Edition: 1
- Published: July 14, 2017
- Imprint: Academic Press
- Hardback ISBN: 9780128037966
- eBook ISBN: 9780128038000
YG
Yasemin Gürsoy Özdemir
SB
Sibel Bozdag Pehlivan
ES