
Nanomedicine in Central Nervous System Injury and Repair
- 1st Edition, Volume 137 - November 11, 2017
- Imprint: Academic Press
- Editors: Peter Jenner, Hari Shanker Sharma, Aruna Sharma
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 2 3 8 1 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 2 3 8 2 - 9
Nanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive ch… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteNanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage, and how Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. In addition, the Neuroprotective effects of a multimodal drug cerebrolysin are explored, as is how Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease.
This series reviews current knowledge and understanding on how to repair the damaged spinal cord and brain with nanomedicine, detailing new therapeutic advances and providing a starting point for researchers and practitioners entering the field.
- Provides cutting-edge research on the damaged spinal cord and brain
- Presents new therapeutic advances
- Reviews current knowledge and understanding
Pre-clinical scientists, clinicians and physicians
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- References
- Acknowledgments
- Chapter One Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders
- Abstract
- 1 Introduction
- 2 Physical Delivery
- 3 Nonphysical Methods
- 4 Conclusion
- References
- Chapter Two Impact of Inflammation on the Blood–Neural Barrier and Blood–Nerve Interface_ From Review to Therapeutic Preview
- Abstract
- 1 Introduction
- 2 Blood–Nerve Interface
- 3 Mast Cells and the BBB
- 4 Immune Cell Interactions Amplify Neuroinflammation
- 5 Neuroinflammation and Aging
- 6 Mast Cells and Glia as Therapeutic Targets
- 7 Conclusion and Perspectives
- References
- Chapter Three Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology: New Roles of Nanowired Drug Delivery for Neuroprotection
- Abstract
- 1 Introduction
- 2 Histamine in the Spinal Cord
- 3 Histamine and Nitric Oxide Interaction
- 4 Histamine and the Spinal Cord Microcirculation
- 5 Histamine and the BSCB Permeability
- 6 Histamine and Spinal Cord Edema
- 7 Nanowired Drug Delivery Enhances Neuroprotection
- 8 Our Investigations on Histamine-Receptor Modulation and nNOS Expression in SCI
- 9 Histamine Receptors Influence Spinal Cord Pathology and nNOS Expression
- 10 Histamine-Receptor Modulation and BSCB in SCI
- 11 Histamine-Receptor Modulation and SCBF in SCI
- 12 Histamine-Receptor Modulation and Spinal Cord Edema in SCI
- 13 Histamine-Receptor Modulation and Neuronal NOS Expression in SCI
- 14 Histamine-Receptor Modulation and Neuronal Changes in SCI
- 15 TiO2-Nanowired Delivery of Histamine H2 Receptor Antagonists Has Superior Neuroprotective Effects in SCI
- 16 Functional Significance of Our Findings
- References
- Chapter Four Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease
- Abstract
- 1 Introduction
- 2 Development
- 3 Conclusions
- References
- Edition: 1
- Volume: 137
- Published: November 11, 2017
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128123812
- eBook ISBN: 9780128123829
PJ
Peter Jenner
HS
Hari Shanker Sharma
AS